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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qocANPEphrin type-A receptor 32.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2qocANPEphrin type-A receptor 32.7.10.11.000
4gk4L90Ephrin type-A receptor 32.7.10.10.561
2qo7ANPEphrin type-A receptor 32.7.10.10.540
2henADPEphrin type-B receptor 22.7.10.10.512
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.510
2qoqANPEphrin type-A receptor 32.7.10.10.499
4jia1K3Tyrosine-protein kinase JAK2/0.462
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
2xvdAS6Ephrin type-B receptor 42.7.10.10.448
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
3bu5ATPInsulin receptor2.7.10.10.440
4g2fC07Ephrin type-A receptor 32.7.10.10.440