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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qo9ANPEphrin type-A receptor 32.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2qo9ANPEphrin type-A receptor 32.7.10.11.000
4g2fC07Ephrin type-A receptor 32.7.10.10.637
2qo7ANPEphrin type-A receptor 32.7.10.10.611
2qoqANPEphrin type-A receptor 32.7.10.10.575
4gk3L87Ephrin type-A receptor 32.7.10.10.573
2henADPEphrin type-B receptor 22.7.10.10.561
2y6o1N1Ephrin type-A receptor 42.7.10.10.560
2qocANPEphrin type-A receptor 32.7.10.10.559
1jpaANPEphrin type-B receptor 22.7.10.10.556
4gk2L66Ephrin type-A receptor 32.7.10.10.541
2xyuQ9GEphrin type-A receptor 42.7.10.10.534
4gk4L90Ephrin type-A receptor 32.7.10.10.533
4gmy0X5Tyrosine-protein kinase JAK2/0.516
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.507
4bb432WEphrin type-B receptor 42.7.10.10.507
4riyADPEpidermal growth factor receptor2.7.10.10.506
2acxANPG protein-coupled receptor kinase 62.7.11.160.504
5e8wSTUTGF-beta receptor type-12.7.11.300.501
2py3ACPFibroblast growth factor receptor 2/0.498
2yn8STUEphrin type-B receptor 42.7.10.10.498
3vjoANPEpidermal growth factor receptor2.7.10.10.497
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.495
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.493
2vwu7X1Ephrin type-B receptor 42.7.10.10.493
3ac1KZITyrosine-protein kinase Lck2.7.10.20.493
2hog710Serine/threonine-protein kinase Chk12.7.11.10.491
2pzpACPFibroblast growth factor receptor 2/0.487
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.487
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.485
3gxlQIGTGF-beta receptor type-12.7.11.300.485
2ituITQEpidermal growth factor receptor2.7.10.10.484
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.484
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.478
2xvdAS6Ephrin type-B receptor 42.7.10.10.478
3zewSTUEphrin type-B receptor 42.7.10.10.478
2itvANPEpidermal growth factor receptor2.7.10.10.477
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.475
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.475
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.474
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.473
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
4i231C9Epidermal growth factor receptor2.7.10.10.473
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.472
1bygSTUTyrosine-protein kinase CSK/0.471
1u54ACPActivated CDC42 kinase 1/0.471
2of4979Tyrosine-protein kinase Lck2.7.10.20.471
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.471
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.471
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.471
2ittAEEEpidermal growth factor receptor2.7.10.10.470
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.470
4k33ACPFibroblast growth factor receptor 32.7.10.10.470
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.469
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.469
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.469
2vx17X8Ephrin type-B receptor 42.7.10.10.468
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.468
1fwkADPHomoserine kinase2.7.1.390.467
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.467
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4wkqIREEpidermal growth factor receptor2.7.10.10.467
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.466
2vwx7X4Ephrin type-B receptor 42.7.10.10.466
4j97ACPFibroblast growth factor receptor 2/0.466
2itnANPEpidermal growth factor receptor2.7.10.10.465
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.465
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.465
1oiyN41Cyclin-dependent kinase 22.7.11.220.464
2of2547Tyrosine-protein kinase Lck2.7.10.20.464
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.464
4qmzB49Serine/threonine-protein kinase 242.7.11.10.464
2pz5ACPFibroblast growth factor receptor 2/0.463
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.463
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.463
4jia1K3Tyrosine-protein kinase JAK2/0.463
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.462
2vwz7X6Ephrin type-B receptor 42.7.10.10.462
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.462
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.462
2pwlACPFibroblast growth factor receptor 2/0.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.461
4fob0USALK tyrosine kinase receptor2.7.10.10.461
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.460
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.458
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.458
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.457
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.457
2hk51BMTyrosine-protein kinase HCK2.7.10.20.457
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
2wotZZGTGF-beta receptor type-12.7.11.300.456
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.456
3a7jADPSerine/threonine-protein kinase 242.7.11.10.456
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.456
2j0m4STFocal adhesion kinase 12.7.10.20.455
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.455
3cukFADD-amino-acid oxidase1.4.3.30.455
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.455
3il1B5DGlutamate receptor 2/0.455
4qo9627Serine/threonine-protein kinase 242.7.11.10.455
5e8xSTUTGF-beta receptor type-12.7.11.300.454
2x9fX9FEphrin type-B receptor 42.7.10.10.453
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.452
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.452
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.452
3qc9ADPRhodopsin kinase/0.452
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.452
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.452
1rw8580TGF-beta receptor type-12.7.11.300.451
1zrzBI1Protein kinase C iota type2.7.11.130.451
2vwy7X5Ephrin type-B receptor 42.7.10.10.451
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.451
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.451
3mdvCL6Cholesterol 24-hydroxylase/0.451
4c02TAKActivin receptor type-12.7.11.300.451
1mqbANPEphrin type-A receptor 22.7.10.10.450
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4tuvCPZCytochrome P450 1191.140.450
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.449
2eb3ANPEpidermal growth factor receptor2.7.10.10.449
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.449
3c4wATPRhodopsin kinase/0.449
1m17AQ4Epidermal growth factor receptor2.7.10.10.448
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.448
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.448
3cr0809Wee1-like protein kinase2.7.10.20.448
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
3tucFPWTyrosine-protein kinase SYK2.7.10.20.448
4qmlANPSerine/threonine-protein kinase 242.7.11.10.448
4qms1N1Serine/threonine-protein kinase 242.7.11.10.448
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
5a3cNADSIR2 family protein/0.448
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.447
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.447
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.447
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3t8oATPRhodopsin kinase/0.447
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.447
4k8aK8AFocal adhesion kinase 12.7.10.20.447
5cvcPLPSerine racemase/0.447
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2fy4COACholine O-acetyltransferase2.3.1.60.446
2vx07X7Ephrin type-B receptor 42.7.10.10.446
3a7hATPSerine/threonine-protein kinase 242.7.11.10.446
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.446
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4c58824Cyclin-G-associated kinase2.7.11.10.446
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4qmpDKISerine/threonine-protein kinase 242.7.11.10.446
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.445
3c50ADPRhodopsin kinase/0.445
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.445
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.445
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4i22IREEpidermal growth factor receptor2.7.10.10.445
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.445
4qnaX11Serine/threonine-protein kinase 242.7.11.10.445
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.444
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.444
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.444
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4jqeANPCasein kinase II subunit alpha2.7.11.10.444
4wboANWRhodopsin kinase/0.444
2etm7PYFocal adhesion kinase 12.7.10.20.443
2rhrEMOPutative ketoacyl reductase1.3.10.443
3c4zADPRhodopsin kinase/0.443
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.443
3s1dZIRCytokinin dehydrogenase 11.5.99.120.443
3slkNDPPolyketide synthase extender module 2/0.443
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.442
2vd5BI8Myotonin-protein kinase2.7.11.10.442
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.442
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.442
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.442
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.441
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.441
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.441
2wxvWXVCyclin-dependent kinase 22.7.11.220.441
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.441
4oavACP2-5A-dependent ribonuclease3.1.260.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.441
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2b7aIZATyrosine-protein kinase JAK2/0.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
2itzIREEpidermal growth factor receptor2.7.10.10.440
2rghFADAlpha-Glycerophosphate Oxidase/0.440
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
2y05NAPProstaglandin reductase 1/0.440
3c4xATPRhodopsin kinase/0.440
3dmgSAHProbable ribosomal RNA small subunit methyltransferase/0.440
3fhyATPPyridoxal kinase2.7.1.350.440
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440