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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/1.000
4bcmT7ZCyclin-dependent kinase 22.7.11.220.491
3nynSGVG protein-coupled receptor kinase 62.7.11.160.469
3my5RFZCyclin-dependent kinase 22.7.11.220.468
2uzbC75Cyclin-dependent kinase 22.7.11.220.467
3lfqA28Cyclin-dependent kinase 22.7.11.220.464
4nj32KDCyclin-dependent kinase 22.7.11.220.464
1pxoCK7Cyclin-dependent kinase 22.7.11.220.463
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
1finATPCyclin-dependent kinase 22.7.11.220.457
2btsU32Cyclin-dependent kinase 22.7.11.220.457
1fvv107Cyclin-dependent kinase 22.7.11.220.456
1ykr628Cyclin-dependent kinase 22.7.11.220.455
3r7iX9ICyclin-dependent kinase 22.7.11.220.455
3lfsA07Cyclin-dependent kinase 22.7.11.220.454
3rni21ZCyclin-dependent kinase 22.7.11.220.453
4fklCK2Cyclin-dependent kinase 22.7.11.220.452
3ezrEZRCyclin-dependent kinase 22.7.11.220.450
3fz1B98Cyclin-dependent kinase 22.7.11.220.450
3tnwF18Cyclin-dependent kinase 22.7.11.220.450
4bcqTJFCyclin-dependent kinase 22.7.11.220.450
3r1yX76Cyclin-dependent kinase 22.7.11.220.447
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.447
4bcpT3CCyclin-dependent kinase 22.7.11.220.447
1oitHDTCyclin-dependent kinase 22.7.11.220.446
4fv6E57Mitogen-activated protein kinase 12.7.11.240.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
3ezvEZVCyclin-dependent kinase 22.7.11.220.442
3r7uX96Cyclin-dependent kinase 22.7.11.220.442
2fvdLIACyclin-dependent kinase 22.7.11.220.441
2j9mPY8Cyclin-dependent kinase 22.7.11.220.441
3nup3NUCyclin-dependent kinase 62.7.11.220.441