sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2q92 | B23 | Methionine aminopeptidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2q92 | B23 | Methionine aminopeptidase | / | 1.000 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.781 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.757 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.707 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.681 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.634 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.629 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.616 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.603 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.594 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.578 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.576 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.569 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.562 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.561 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.558 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.557 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.551 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.549 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.547 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.539 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.532 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.532 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.520 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.509 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.505 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.504 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.504 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.501 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.496 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.495 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.495 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.491 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.486 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.478 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.475 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.464 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.463 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.461 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.455 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.453 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.453 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.448 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.443 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.441 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.440 |