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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q70DC8Estrogen receptor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2q70DC8Estrogen receptor/1.000
4ivy1GTEstrogen receptor/0.521
3l034OHEstrogen receptor/0.478
1zky689Estrogen receptor/0.471
1x7e244Estrogen receptor/0.467
1yinCM3Estrogen receptor/0.467
2qgtEEDEstrogen receptor/0.465
3qlrNDPDihydrofolate reductase1.5.1.30.462
5hyrESTEstrogen receptor/0.462
2g44T3OEstrogen receptor/0.460
3ollESTEstrogen receptor beta/0.459
2yekEAMBromodomain-containing protein 2/0.457
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.455
2bj4OHTEstrogen receptor/0.454
2fai459Estrogen receptor/0.454
4dma0L8Estrogen receptor/0.453
4iw8KN3Estrogen receptor/0.453
4pxmESTEstrogen receptor/0.451
1rx7FOLDihydrofolate reductase1.5.1.30.450
1rf7DHFDihydrofolate reductase1.5.1.30.449
5dxgESTEstrogen receptor/0.448
1g50ESTEstrogen receptor/0.447
3q95ESLEstrogen receptor/0.446
1gwrESTEstrogen receptor/0.445
1sj0E4DEstrogen receptor/0.444
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4iw61GUEstrogen receptor/0.444
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4j24ESTEstrogen receptor beta/0.443
2g5oDRQEstrogen receptor/0.442
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1errRALEstrogen receptor/0.440
3d7kD7KBenzaldehyde lyase/0.440
3uudESTEstrogen receptor/0.440