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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q0bACPFibroblast growth factor receptor 2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2q0bACPFibroblast growth factor receptor 2/1.000
2pzrACPFibroblast growth factor receptor 2/0.560
4j97ACPFibroblast growth factor receptor 2/0.521
1m17AQ4Epidermal growth factor receptor2.7.10.10.491
4jr3KJREpidermal growth factor receptor2.7.10.10.479
2pwlACPFibroblast growth factor receptor 2/0.477
2pvyACPFibroblast growth factor receptor 2/0.469
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.469
4nks2M2Fibroblast growth factor receptor 1/0.469
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
2pzpACPFibroblast growth factor receptor 2/0.465
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.465
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
3uvqFS8Mitogen-activated protein kinase 14/0.463
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
4jq8KJ8Epidermal growth factor receptor2.7.10.10.455
2of2547Tyrosine-protein kinase Lck2.7.10.20.450
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.447
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.447
2itzIREEpidermal growth factor receptor2.7.10.10.446
3b2tM33Fibroblast growth factor receptor 2/0.446
4fyn0VETyrosine-protein kinase SYK2.7.10.20.445
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2y6o1N1Ephrin type-A receptor 42.7.10.10.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.441