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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/1.000
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.611
1aylATPPhosphoenolpyruvate carboxykinase (ATP)/0.564
1aq2ATPPhosphoenolpyruvate carboxykinase (ATP)/0.541
1ytmATPPhosphoenolpyruvate carboxykinase (ATP)/0.537
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.534
1nzfUPGDNA beta-glucosyltransferase/0.477
4awp99AHeat shock protein HSP 90-alpha/0.464
5cyoGDPSeptin-9/0.460
3pcrGTPADP-ribosylation factor 6/0.459
4dieC5PCytidylate kinase/0.459
5k5zANPUncharacterized protein/0.454
3nbzGTPGTP-binding nuclear protein Ran/0.453
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4z54GDPNeuronal-specific septin-3/0.452
1j39UPGDNA beta-glucosyltransferase/0.451
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.450
4ejmNAPPutative zinc-binding dehydrogenase/0.450
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.449
1k5dGNPGTP-binding nuclear protein Ran/0.448
2xfsJ01Uncharacterized protein/0.448
4eqwFADCoenzyme A disulfide reductase/0.448
4n9iPCGCatabolite expression activator/0.446
1esvLARActin, alpha skeletal muscle/0.445
1o9bNAIQuinate/shikimate dehydrogenase/0.444
2briANPUridylate kinase2.7.4.220.444
3cisATPUniversal stress protein Rv2623/0.444
4a99FADTetX family tetracycline inactivation enzyme/0.444
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.442
3w3zGTPGTP-binding nuclear protein Ran/0.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fdpFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.442
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3t1tGDPProbable gliding protein mglA/0.441
4l8u9AZSerum albumin/0.441
1gv0NADMalate dehydrogenase/0.440
3cobADPKinesin heavy chain-like protein/0.440