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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pogWSTEstrogen receptor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pogWSTEstrogen receptor/1.000
1yinCM3Estrogen receptor/0.611
1xp6AIUEstrogen receptor/0.586
1sj0E4DEstrogen receptor/0.584
1uomPTIEstrogen receptor/0.562
2jf9OHTEstrogen receptor/0.536
1errRALEstrogen receptor/0.499
2gpvOHTEstrogen-related receptor gamma/0.488
1ndeMONEstrogen receptor beta/0.487
2qe4JJ3Estrogen receptor/0.480
1xqcAEJEstrogen receptor/0.464
3nxxNDPDihydrofolate reductase1.5.1.30.461
3wmxNADNAD dependent epimerase/dehydratase/0.454
3gc9B45Mitogen-activated protein kinase 112.7.11.240.452
4b1fKRHGlutamate racemase/0.448
5jr34MUCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.443
2bj4OHTEstrogen receptor/0.442
2p15EZTEstrogen receptor/0.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
5k2bZMAAdenosine receptor A2a/0.441