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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pmoHMDProtein kinase 7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pmoHMDProtein kinase 7/1.000
4dgmAGICasein kinase II subunit alpha2.7.11.10.458
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.443
4hge15VTyrosine-protein kinase JAK2/0.442