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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pk3A2RGDP-6-deoxy-D-mannose reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2pk3A2RGDP-6-deoxy-D-mannose reductase/1.000
2pk3GDDGDP-6-deoxy-D-mannose reductase/0.600
2z95NDPGDP-mannose 4,6-dehydratase/0.458
3otwCOAPhosphopantetheine adenylyltransferase/0.456
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.447
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.444
2zsaADPPantothenate kinase2.7.1.330.443
2gjlFMNNitronate monooxygenase1.13.12.160.440
2oapANPType II secretion system protein (GspE-2)/0.440