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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdyFIDAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pdyFIDAldose reductase1.1.1.211.000
2iqdLPAAldose reductase1.1.1.210.696
2inzOHPAldose reductase1.1.1.210.680
2f2kTGGAldose reductase1.1.1.210.607
2fz8ZSTAldose reductase1.1.1.210.603
1pwmFIDAldose reductase1.1.1.210.564
2pdu393Aldose reductase1.1.1.210.549
2pdwFIDAldose reductase1.1.1.210.545
3q67NAPAldose reductase1.1.1.210.536
3u2cSUZAldose reductase1.1.1.210.520
2fz9ZSTAldose reductase1.1.1.210.518
3s3gTLTAldose reductase1.1.1.210.501
1ieiZESAldose reductase1.1.1.210.496
2is72CLAldose reductase1.1.1.210.494
3ghsLDTAldose reductase1.1.1.210.488
2nvcITAAldose reductase1.1.1.210.482
2pdxZSTAldose reductase1.1.1.210.482
2pdg47DAldose reductase1.1.1.210.480
2pdkSBIAldose reductase1.1.1.210.476
3ghrLDTAldose reductase1.1.1.210.465
3p2vDOYAldose reductase1.1.1.210.464
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
1ef3FIDAldose reductase1.1.1.210.459
4gabFIDAldo-keto reductase family 1 member B101.1.10.458
2hv5ZSTAldose reductase1.1.1.210.457
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
1ah0SBIAldose reductase1.1.1.210.454
3mb9ZSTAldose reductase1.1.1.210.454
1ekoI84Aldose reductase1.1.1.210.453
2hvnZSTAldose reductase1.1.1.210.453
2pd9FIDAldose reductase1.1.1.210.452
2pdfZSTAldose reductase1.1.1.210.450
2zevIPEGeranylgeranyl pyrophosphate synthase/0.447
4gca2X9Aldose reductase1.1.1.210.447
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.444
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.444
2hejNDPAldo-keto reductase family 1 member C211.1.10.442