sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pdk | SBI | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.719 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.683 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.664 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.653 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.653 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.653 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.645 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.641 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.636 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.633 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.633 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.632 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.630 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.628 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.626 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.619 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.619 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2acu | NAP | Aldose reductase | 1.1.1.21 | 0.587 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.575 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.569 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.566 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.561 | |
| 1ah4 | NAP | Aldose reductase | 1.1.1.21 | 0.548 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.546 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.531 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.527 | |
| 2nvd | ITB | Aldose reductase | 1.1.1.21 | 0.527 | |
| 3v36 | NAP | Aldose reductase | 1.1.1.21 | 0.525 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.510 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.509 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.509 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.507 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.502 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.500 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.500 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.496 | |
| 2acq | NAP | Aldose reductase | 1.1.1.21 | 0.495 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.493 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.493 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.493 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.493 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.493 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.493 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.492 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 1rxj | BNI | Streptavidin | / | 0.486 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.486 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.484 | |
| 1u08 | PLP | Methionine aminotransferase | / | 0.483 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.483 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.479 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.479 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.478 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.478 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.477 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.477 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.476 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.476 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.476 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.476 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.474 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.474 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.473 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.473 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.472 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.472 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.472 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.471 | |
| 2hzq | STR | Apolipoprotein D | / | 0.471 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.471 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.471 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.470 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.470 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.470 | |
| 3h7u | NAP | NADPH-dependent aldo-keto reductase, chloroplastic | / | 0.470 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.468 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.467 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.467 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.467 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.467 | |
| 2qry | TPS | Thiamine-binding periplasmic protein | / | 0.467 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.467 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.466 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.465 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.465 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.464 | |
| 2po3 | T4K | 4-dehydrase | / | 0.464 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.464 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.464 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.464 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.463 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.463 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.463 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.463 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.463 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.463 | |
| 4nqg | CZH | Mitrocomin | / | 0.463 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.463 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.461 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.461 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.461 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.461 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.461 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.461 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.461 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.461 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.461 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.460 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.460 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.460 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.459 | |
| 2ejz | SAH | Diphthine synthase | / | 0.459 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.459 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.458 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 4phl | PIL | Phosphodiesterase | / | 0.458 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.457 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.457 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.456 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
| 4azw | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.456 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.456 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.455 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.455 | |
| 1s36 | CEI | Obelin | / | 0.455 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.455 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.455 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.454 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.454 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.454 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.454 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.454 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.454 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.453 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.453 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.453 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.452 | |
| 2h7j | H7J | Cathepsin S | 3.4.22.27 | 0.452 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.452 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.451 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.450 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.450 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.450 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.450 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.450 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.450 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.450 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.450 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.450 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.449 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.449 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.449 | |
| 4j7h | TRH | PCZA361.3 | / | 0.449 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.449 | |
| 4mrx | CZH | Obelin | / | 0.449 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.449 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.449 | |
| 1e6z | NGO | Chitinase | / | 0.448 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.448 | |
| 3hth | PRL | EbrA repressor | / | 0.448 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.448 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.448 | |
| 4kmz | FOL | Folate receptor beta | / | 0.448 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.447 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2bxo | OPB | Serum albumin | / | 0.447 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.447 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.447 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.446 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.446 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.445 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.445 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.445 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4gvs | F4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.445 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.445 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.444 | |
| 2c97 | JCL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.444 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1uhh | CZP | Aequorin-2 | / | 0.443 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.443 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3arv | SAU | Chitinase A | / | 0.443 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.442 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4jui | EGR | Tannase | / | 0.442 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.441 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.441 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.441 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.441 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4kxj | P34 | Nucleoprotein | / | 0.441 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.441 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.441 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.440 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.440 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.440 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.440 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.440 | |
| 5jdz | SAH | Methyl transferase | / | 0.440 |