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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdbZSTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2pdbZSTAldose reductase1.1.1.211.000
2pd5ZSTAldose reductase1.1.1.210.845
2pdn47DAldose reductase1.1.1.210.723
2hvoZSTAldose reductase1.1.1.210.665
1z3n3NAAldose reductase1.1.1.210.654
3lenZSTAldose reductase1.1.1.210.650
2pdxZSTAldose reductase1.1.1.210.648
3mb9ZSTAldose reductase1.1.1.210.648
2fz8ZSTAldose reductase1.1.1.210.642
3m0iZSTAldose reductase1.1.1.210.638
2dv0ZSTAldose reductase1.1.1.210.637
2duzZSTAldose reductase1.1.1.210.635
1t40ID5Aldose reductase1.1.1.210.631
1t41ID5Aldose reductase1.1.1.210.630
2fz9ZSTAldose reductase1.1.1.210.629
4gca2X9Aldose reductase1.1.1.210.629
2hv5ZSTAldose reductase1.1.1.210.628
3m64393Aldose reductase1.1.1.210.627
3g5eQ74Aldose reductase1.1.1.210.625
2ikj393Aldose reductase1.1.1.210.623
3lboLDTAldose reductase1.1.1.210.618
2pdh47DAldose reductase1.1.1.210.617
2i16LDTAldose reductase1.1.1.210.616
3ld5LDTAldose reductase1.1.1.210.616
2duxZSTAldose reductase1.1.1.210.613
3ghuLDTAldose reductase1.1.1.210.610
3lqlLDTAldose reductase1.1.1.210.607
3ghrLDTAldose reductase1.1.1.210.606
1us0LDTAldose reductase1.1.1.210.605
1z8962PAldose reductase1.1.1.210.605
3m4h388Aldose reductase1.1.1.210.599
2pdg47DAldose reductase1.1.1.210.598
4yu153NAldose reductase1.1.1.210.598
2pzn393Aldose reductase1.1.1.210.595
3ghtLDTAldose reductase1.1.1.210.595
2pdp393Aldose reductase1.1.1.210.594
2qxwLDTAldose reductase1.1.1.210.593
3mc5393Aldose reductase1.1.1.210.592
2pdu393Aldose reductase1.1.1.210.591
2iki388Aldose reductase1.1.1.210.589
1frbZSTAldose reductase-related protein 2/0.587
3ghsLDTAldose reductase1.1.1.210.587
2i17LDTAldose reductase1.1.1.210.585
3t423T4Aldose reductase1.1.1.210.583
3lz5LDTAldose reductase1.1.1.210.580
1pwlBFIAldose reductase1.1.1.210.579
2pdc393Aldose reductase1.1.1.210.576
2pdj393Aldose reductase1.1.1.210.572
2pdfZSTAldose reductase1.1.1.210.568
2ikhLITAldose reductase1.1.1.210.558
2pdlTOLAldose reductase1.1.1.210.533
1ieiZESAldose reductase1.1.1.210.519
2fzdTOLAldose reductase1.1.1.210.517
2pdq47DAldose reductase1.1.1.210.510
1gt5BZQOdorant-binding protein/0.491
4bj9UHBTankyrase-22.4.2.300.487
1ut6A8NAcetylcholinesterase3.1.1.70.486
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.485
3f3y4OABile salt sulfotransferase2.8.2.140.485
4kmzFOLFolate receptor beta/0.485
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.484
3b82NADExotoxin A2.4.2.360.484
1ry0PG2Aldo-keto reductase family 1 member C3/0.483
2fzbTOLAldose reductase1.1.1.210.483
2pd9FIDAldose reductase1.1.1.210.482
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.480
4bjbP34Tankyrase-22.4.2.300.478
3ipq965Oxysterols receptor LXR-alpha/0.477
4dbw511Aldo-keto reductase family 1 member C3/0.477
4pnmNU1Tankyrase-22.4.2.300.477
4tjy3GNTankyrase-22.4.2.300.476
1zuaTOLAldo-keto reductase family 1 member B101.1.10.475
4bjcRPBTankyrase-22.4.2.300.475
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.475
1ah3TOLAldose reductase1.1.1.210.474
2iqdLPAAldose reductase1.1.1.210.474
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.474
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.474
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.472
4kebFOLDihydrofolate reductase1.5.1.30.472
3r8hZOMAldo-keto reductase family 1 member C3/0.471
5fd8A5APutative carboxypeptidase yocD/0.470
2xupTZ5Acetylcholinesterase3.1.1.70.469
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.469
2xufTZ4Acetylcholinesterase3.1.1.70.468
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
1ekoI84Aldose reductase1.1.1.210.467
2f3815MAldo-keto reductase family 1 member C3/0.467
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.467
4k4eK4ETankyrase-12.4.2.300.467
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
4ey7E20Acetylcholinesterase3.1.1.70.466
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.465
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.465
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.464
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.464
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.464
1zgbA1EAcetylcholinesterase3.1.1.70.463
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.462
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.462
4mrxCZHObelin/0.462
2w6cBM4Acetylcholinesterase3.1.1.70.461
3u3o3QVSulfotransferase 1A12.8.2.10.461
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.461
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
2xuoTZ4Acetylcholinesterase3.1.1.70.460
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2xuhTZ4Acetylcholinesterase3.1.1.70.459
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.459
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.459
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
4li71XPTankyrase-12.4.2.300.459
1ry8RUTAldo-keto reductase family 1 member C3/0.458
3s3gTLTAldose reductase1.1.1.210.458
5kgpACOPredicted acetyltransferase/0.458
4u163C0Muscarinic acetylcholine receptor M3/0.458
1e66HUXAcetylcholinesterase3.1.1.70.457
1ja1FMNNADPH--cytochrome P450 reductase/0.457
1pwmFIDAldose reductase1.1.1.210.457
3zoiM2WIsopenicillin N synthase1.21.3.10.457
2cekN8TAcetylcholinesterase3.1.1.70.456
2inzOHPAldose reductase1.1.1.210.456
2pdmZSTAldose reductase1.1.1.210.456
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
4gabFIDAldo-keto reductase family 1 member B101.1.10.456
4jtqFLPAldo-keto reductase family 1 member C2/0.456
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.455
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.455
3ugrIMNAldo-keto reductase family 1 member C3/0.455
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.455
4fam0SZAldo-keto reductase family 1 member C3/0.455
4jq4IMNAldo-keto reductase family 1 member C2/0.455
1ah0SBIAldose reductase1.1.1.210.454
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2aclL05Oxysterols receptor LXR-alpha/0.454
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.454
4e0u0MVCyclic dipeptide N-prenyltransferase/0.454
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.454
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.453
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.453
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.453
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.453
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.452
2pdiZSTAldose reductase1.1.1.210.452
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.452
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.452
1ej3CZHAequorin-2/0.451
1el4CTZObelin/0.451
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1zgcA2EAcetylcholinesterase3.1.1.70.451
2hzqSTRApolipoprotein D/0.451
2is72CLAldose reductase1.1.1.210.451
2rqfJH3Hemolymph juvenile hormone binding protein/0.451
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.451
2xujTZ5Acetylcholinesterase3.1.1.70.451
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.451
1ef3FIDAldose reductase1.1.1.210.450
1lqaNDPProtein tas/0.450
1p8dCO1Oxysterols receptor LXR-beta/0.450
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2cbqTH2Neocarzinostatin/0.450
2nvcITAAldose reductase1.1.1.210.450
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.450
3mjrAC2Deoxycytidine kinase2.7.1.740.450
4dbuBT9Aldo-keto reductase family 1 member C3/0.450
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.450
4l1xNAPAldo-keto reductase family 1 member C2/0.450
1dgfNDPCatalase1.11.1.60.449
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2wmdZZ0NmrA-like family domain-containing protein 1/0.449
3pkaY02Methionine aminopeptidase 2/0.449
4bfyZVYPantothenate kinase2.7.1.330.449
2aouCQAHistamine N-methyltransferase2.1.1.80.448
2x9vTMQPteridine reductase/0.448
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3fznD7KBenzoylformate decarboxylase4.1.1.70.448
4bvhOCZNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.448
2op18PCEnoyl-ACP reductase/0.447
2vcmM11Isopenicillin N synthase1.21.3.10.447
2zs9ADPPantothenate kinase2.7.1.330.447
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.447
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.447
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
1vkgCRIHistone deacetylase 83.5.1.980.446
1w76GNTAcetylcholinesterase3.1.1.70.446
2c6c24IGlutamate carboxypeptidase 23.4.17.210.446
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3ntrNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.446
3sfy3FYUncharacterized protein/0.446
4li61XOTankyrase-12.4.2.300.446
7catNDPCatalase1.11.1.60.446
1odcA8BAcetylcholinesterase3.1.1.70.445
1qvtPRLHTH-type transcriptional regulator QacR/0.445
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.445
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.445
2evcFC3Methionine aminopeptidase/0.445
2ga2A19Methionine aminopeptidase 2/0.445
4wevSUZAldo-keto reductase family 1 member B101.1.10.445
1el3I84Aldose reductase1.1.1.210.444
1rxjBNIStreptavidin/0.444
1s2cFLFAldo-keto reductase family 1 member C3/0.444
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
1xf0ASDAldo-keto reductase family 1 member C3/0.444
1yw9A84Methionine aminopeptidase 2/0.444
3pn1IVHDNA ligase/0.444
5jqhCAUBeta-2 adrenergic receptor/0.444
1gky5GPGuanylate kinase2.7.4.80.443
1hb1OCVIsopenicillin N synthase1.21.3.10.443
1ihiIU5Aldo-keto reductase family 1 member C2/0.443
1ohkCOPDihydrofolate reductase1.5.1.30.443
1stpBTNStreptavidin/0.443
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2iu8UD1UDP-3-O-acylglucosamine N-acyltransferase2.3.10.443
2wu4HBPAcetylcholinesterase3.1.1.70.443
3h3qH13Collagen type IV alpha-3-binding protein/0.443
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.443
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.443
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.443
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
1kwcBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.442
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1ygjRMCPyridoxal kinase2.7.1.350.442
1yw7A41Methionine aminopeptidase 2/0.442
2d06ESTSulfotransferase 1A12.8.2.10.442
2xltNA0Putative flavin-containing monooxygenase/0.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3nwlNDPCatalase1.11.1.60.442
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3r7mSUZAldo-keto reductase family 1 member C3/0.442
4dch4DCGlucokinase2.7.1.20.442
4i5xFLFAldo-keto reductase family 1 member B101.1.10.442
4mzuTYDWxcM-like protein/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4u95MIYMultidrug efflux pump subunit AcrB/0.442
3ny9JSZBeta-2 adrenergic receptor/0.442
1dgbNDPCatalase1.11.1.60.441
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
3d2dRENReticuline oxidase1.21.3.30.441
3fu83DMLaccase-11.10.3.20.441
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.441
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.441
3p2vDOYAldose reductase1.1.1.210.441
3pkeY10Methionine aminopeptidase 2/0.441
4c717RD3-oxoacyl-ACP synthase/0.441
4hyf1AKTankyrase-22.4.2.300.441
4kn0MTXFolate receptor beta/0.441
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.441
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4pnrG18Tankyrase-22.4.2.300.441
4yfy0FXVioF/0.441
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.440
1o5rFR9Adenosine deaminase3.5.4.40.440
1pz1NAPGeneral stress protein 69/0.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2bfmTOPPteridine reductase 11.5.1.330.440
2oazI96Methionine aminopeptidase 2/0.440
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.440
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.440
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.440
3h3r14HCollagen type IV alpha-3-binding protein/0.440
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.440
4hmn16JAldo-keto reductase family 1 member C3/0.440
4phlPILPhosphodiesterase/0.440
8catNDPCatalase1.11.1.60.440