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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p2i608Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2p2i608Vascular endothelial growth factor receptor 22.7.10.11.000
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.628
3efl706Vascular endothelial growth factor receptor 22.7.10.10.585
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.570
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.561
3hng8STVascular endothelial growth factor receptor 12.7.10.10.560
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.538
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.536
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.533
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.533
2xir00JVascular endothelial growth factor receptor 22.7.10.10.520
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.519
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.479
4qrc0LIFibroblast growth factor receptor 42.7.10.10.479
2hyySTITyrosine-protein kinase ABL12.7.10.20.477
4aa0AA0Mitogen-activated protein kinase 14/0.477
1iepSTITyrosine-protein kinase ABL12.7.10.20.475
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.473
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.467
3hv5R24Mitogen-activated protein kinase 14/0.463
4o2z046Mitogen-activated protein kinase/0.462
3kq7KQ7Mitogen-activated protein kinase 14/0.455
3ctj320Hepatocyte growth factor receptor2.7.10.10.454
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.449
4eyjN61Mitogen-activated protein kinase 132.7.11.240.447
3zsh469Mitogen-activated protein kinase 14/0.441