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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2p2h994Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2p2h994Vascular endothelial growth factor receptor 22.7.10.11.000
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.586
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.583
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.562
4nks2M2Fibroblast growth factor receptor 1/0.562
4nka2K7Fibroblast growth factor receptor 1/0.547
2of4979Tyrosine-protein kinase Lck2.7.10.20.531
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.530
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.529
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.528
4c62XWWTyrosine-protein kinase JAK2/0.527
4f640S8Fibroblast growth factor receptor 1/0.527
3s4qNK0Mitogen-activated protein kinase 14/0.526
2of2547Tyrosine-protein kinase Lck2.7.10.20.525
2qo9ANPEphrin type-A receptor 32.7.10.10.523
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.518
1u54ACPActivated CDC42 kinase 1/0.517
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.517
3vjoANPEpidermal growth factor receptor2.7.10.10.517
4gk3L87Ephrin type-A receptor 32.7.10.10.517
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.516
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.516
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.515
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.515
5e8xSTUTGF-beta receptor type-12.7.11.300.515
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.514
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.512
2itnANPEpidermal growth factor receptor2.7.10.10.512
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.512
4jr3KJREpidermal growth factor receptor2.7.10.10.512
2eb3ANPEpidermal growth factor receptor2.7.10.10.510
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.510
2yn8STUEphrin type-B receptor 42.7.10.10.509
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.507
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.507
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.507
4y95746Tyrosine-protein kinase/0.506
4y93746Tyrosine-protein kinase/0.505
3ac2KSETyrosine-protein kinase Lck2.7.10.20.504
4cd0AWJALK tyrosine kinase receptor2.7.10.10.504
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.503
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.502
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.502
4i231C9Epidermal growth factor receptor2.7.10.10.502
4j97ACPFibroblast growth factor receptor 2/0.501
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.500
4fob0USALK tyrosine kinase receptor2.7.10.10.500
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.498
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.498
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.498
1zyjBI5Mitogen-activated protein kinase 14/0.497
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.497
2py3ACPFibroblast growth factor receptor 2/0.497
2y6o1N1Ephrin type-A receptor 42.7.10.10.497
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.497
2itqITQEpidermal growth factor receptor2.7.10.10.496
2hk51BMTyrosine-protein kinase HCK2.7.10.20.495
2xyuQ9GEphrin type-A receptor 42.7.10.10.494
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.494
2xp2VGHALK tyrosine kinase receptor2.7.10.10.493
4gk2L66Ephrin type-A receptor 32.7.10.10.493
2fgiPD1Fibroblast growth factor receptor 1/0.492
3ac1KZITyrosine-protein kinase Lck2.7.10.20.492
2hog710Serine/threonine-protein kinase Chk12.7.11.10.491
2zb0GK3Mitogen-activated protein kinase 14/0.491
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.491
4hjoAQ4Epidermal growth factor receptor2.7.10.10.491
4riyADPEpidermal growth factor receptor2.7.10.10.491
4nk92K5Fibroblast growth factor receptor 1/0.490
4wkqIREEpidermal growth factor receptor2.7.10.10.489
5aaaVGHALK tyrosine kinase receptor2.7.10.10.488
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.487
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.486
2itzIREEpidermal growth factor receptor2.7.10.10.486
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.485
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.485
4aa5NQBMitogen-activated protein kinase 14/0.485
4fnzNZFALK tyrosine kinase receptor2.7.10.10.485
4dce0JFALK tyrosine kinase receptor2.7.10.10.484
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.483
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.483
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.483
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.481
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.481
4eh60ONMitogen-activated protein kinase 14/0.481
4id71G0Activated CDC42 kinase 1/0.481
4jq7KJQEpidermal growth factor receptor2.7.10.10.481
2pzrACPFibroblast growth factor receptor 2/0.480
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.480
2itwITQEpidermal growth factor receptor2.7.10.10.479
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.479
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
1agwSU2Fibroblast growth factor receptor 1/0.478
2balPQAMitogen-activated protein kinase 14/0.478
2pwlACPFibroblast growth factor receptor 2/0.478
3dt1P40Mitogen-activated protein kinase 14/0.478
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.478
4ic7ANPMitogen-activated protein kinase 72.7.11.240.478
4kiq1RAMitogen-activated protein kinase 14/0.478
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.477
2rg6287Mitogen-activated protein kinase 14/0.476
4g2fC07Ephrin type-A receptor 32.7.10.10.476
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.475
2itvANPEpidermal growth factor receptor2.7.10.10.475
2pzpACPFibroblast growth factor receptor 2/0.475
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.475
4jq8KJ8Epidermal growth factor receptor2.7.10.10.475
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.475
4hvh19RTyrosine-protein kinase JAK32.7.10.20.474
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.473
3tucFPWTyrosine-protein kinase SYK2.7.10.20.473
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.472
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.472
2vwx7X4Ephrin type-B receptor 42.7.10.10.472
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
3w33W19Epidermal growth factor receptor2.7.10.10.472
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.471
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.471
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.471
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.471
2pvyACPFibroblast growth factor receptor 2/0.470
2zybKSLTyrosine-protein kinase Lck2.7.10.20.470
3fklFKLMitogen-activated protein kinase 14/0.470
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.470
4gmy0X5Tyrosine-protein kinase JAK2/0.470
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.470
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.470
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.470
1oecAA2Fibroblast growth factor receptor 2/0.469
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.469
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.469
3uvqFS8Mitogen-activated protein kinase 14/0.469
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.469
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.469
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.469
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.468
3gfeP37Mitogen-activated protein kinase 14/0.468
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.467
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.467
2itpAEEEpidermal growth factor receptor2.7.10.10.466
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.466
3uvp048Mitogen-activated protein kinase 14/0.466
2vwu7X1Ephrin type-B receptor 42.7.10.10.465
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.465
4f630S7Fibroblast growth factor receptor 1/0.465
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.464
2vd5BI8Myotonin-protein kinase2.7.11.10.464
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.464
4anqVGHALK tyrosine kinase receptor2.7.10.10.464
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.464
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
1xkkFMMEpidermal growth factor receptor2.7.10.10.463
3a62STURibosomal protein S6 kinase beta-12.7.11.10.463
3q5iANPProtein kinase, putative/0.463
4gk4L90Ephrin type-A receptor 32.7.10.10.463
5e8wSTUTGF-beta receptor type-12.7.11.300.463
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2pz5ACPFibroblast growth factor receptor 2/0.462
2qocANPEphrin type-A receptor 32.7.10.10.462
3fln3FNMitogen-activated protein kinase 14/0.462
2i0ePDSProtein kinase C beta type2.7.11.130.461
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.461
4c61LMMTyrosine-protein kinase JAK2/0.461
4hyu1BKMitogen-activated protein kinase 82.7.11.240.461
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.460
2rg5279Mitogen-activated protein kinase 14/0.460
4hvg19QTyrosine-protein kinase JAK32.7.10.20.460
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.459
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.459
3fskRO6Mitogen-activated protein kinase 14/0.459
1zrzBI1Protein kinase C iota type2.7.11.130.458
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.458
3acjKSSTyrosine-protein kinase Lck2.7.10.20.457
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.457
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.457
2xa4AZ5Tyrosine-protein kinase JAK2/0.456
2xvdAS6Ephrin type-B receptor 42.7.10.10.456
3l8xN4DMitogen-activated protein kinase 14/0.456
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.456
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.456
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.456
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
2ittAEEEpidermal growth factor receptor2.7.10.10.455
2j0k4STFocal adhesion kinase 12.7.10.20.455
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.455
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.455
4jrvKJVEpidermal growth factor receptor2.7.10.10.455
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.455
1bygSTUTyrosine-protein kinase CSK/0.454
1di9MSQMitogen-activated protein kinase 14/0.454
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.454
2yfxVGHALK tyrosine kinase receptor2.7.10.10.454
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.454
4ng5PFBAlcohol dehydrogenase E chain1.1.1.10.454
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.453
2j7t274Serine/threonine-protein kinase 102.7.11.10.453
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.453
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.453
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.453
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.453
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2vx17X8Ephrin type-B receptor 42.7.10.10.452
3fi4FI4Mitogen-activated protein kinase 14/0.452
3mpt1GKMitogen-activated protein kinase 14/0.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.452
3flwFLWMitogen-activated protein kinase 14/0.451
3nww3NWMitogen-activated protein kinase 14/0.451
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.451
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2vwy7X5Ephrin type-B receptor 42.7.10.10.450
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.450
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.450
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.450
4kip1R9Mitogen-activated protein kinase 14/0.450
1rw8580TGF-beta receptor type-12.7.11.300.449
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.449
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.449
3ocgOCGMitogen-activated protein kinase 14/0.449
1w84L12Mitogen-activated protein kinase 14/0.448
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.448
2x9fX9FEphrin type-B receptor 42.7.10.10.448
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.448
3mvm39PMitogen-activated protein kinase 14/0.448
3vryB43Tyrosine-protein kinase HCK2.7.10.20.448
4ccbOFGALK tyrosine kinase receptor2.7.10.10.448
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.448
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.448
5aacVGHALK tyrosine kinase receptor2.7.10.10.448
1mvsDTMDihydrofolate reductase1.5.1.30.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
4aa4QC0Mitogen-activated protein kinase 14/0.447
4aotGW8Serine/threonine-protein kinase 102.7.11.10.447
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.446
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
2i40BLZCyclin-dependent kinase 22.7.11.220.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.446
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.446
3eb0DRKUncharacterized protein/0.446
3mvl38PMitogen-activated protein kinase 14/0.446
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.446
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.445
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.445
3gxlQIGTGF-beta receptor type-12.7.11.300.445
3hx4ANPCalmodulin-domain protein kinase 1/0.445
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.445
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.445
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2acxANPG protein-coupled receptor kinase 62.7.11.160.444
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.444
2wouZZFTGF-beta receptor type-12.7.11.300.444
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.444
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.444
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1x2hLPALipoate-protein ligase A6.3.1.200.443
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.443
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.443
4bb432WEphrin type-B receptor 42.7.10.10.443
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.443
4lopSB4Mitogen-activated protein kinase 14/0.443
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.442
2gs7ANPEpidermal growth factor receptor2.7.10.10.442
2h96893Mitogen-activated protein kinase 82.7.11.240.442
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.442
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.442
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.442
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.442
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.441
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.441
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.441
4l4cCAMCamphor 5-monooxygenase1.14.15.10.441
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.440
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.440
2vnhFADNADPH:ferredoxin reductase/0.440
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.440
3b2tM33Fibroblast growth factor receptor 2/0.440
3lctADPALK tyrosine kinase receptor2.7.10.10.440
4h3g10QBeta-secretase 13.4.23.460.440
5kj6PFBAlcohol dehydrogenase E chain1.1.1.10.440