Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2oh4GIGVascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2oh4GIGVascular endothelial growth factor receptor 22.7.10.11.000
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.559
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.552
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.551
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.540
3ctj320Hepatocyte growth factor receptor2.7.10.10.540
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.535
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.532
2i0ePDSProtein kinase C beta type2.7.11.130.531
3cqeP91Wee1-like protein kinase2.7.10.20.526
4qrc0LIFibroblast growth factor receptor 42.7.10.10.518
4tyj0LIFibroblast growth factor receptor 42.7.10.10.517
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.516
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.516
4fnyI3KALK tyrosine kinase receptor2.7.10.10.514
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.509
4agcAXIVascular endothelial growth factor receptor 22.7.10.10.509
3eta351Insulin receptor2.7.10.10.508
2z2w770Wee1-like protein kinase2.7.10.20.507
3zsh469Mitogen-activated protein kinase 14/0.507
3tubFPUTyrosine-protein kinase SYK2.7.10.20.505
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.503
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.499
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.498
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.497
2io6330Wee1-like protein kinase2.7.10.20.497
3vw8DF6Hepatocyte growth factor receptor2.7.10.10.497
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.497
3cth319Hepatocyte growth factor receptor2.7.10.10.496
4uhrNGIAdenosine receptor A2a/0.496
2qu5276Vascular endothelial growth factor receptor 22.7.10.10.495
3e92G6AMitogen-activated protein kinase 14/0.492
3itzP66Mitogen-activated protein kinase 14/0.491
2ofv242Tyrosine-protein kinase Lck2.7.10.20.490
2vwx7X4Ephrin type-B receptor 42.7.10.10.490
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.490
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.489
4nka2K7Fibroblast growth factor receptor 1/0.489
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.489
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.488
3qri919Tyrosine-protein kinase ABL12.7.10.20.487
4f640S8Fibroblast growth factor receptor 1/0.487
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.485
1w83L11Mitogen-activated protein kinase 14/0.485
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.485
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.485
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.484
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.484
1m52P17Tyrosine-protein kinase ABL12.7.10.20.482
3hub469Mitogen-activated protein kinase 14/0.480
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.480
2zd1T27Gag-Pol polyprotein2.7.7.490.479
4j97ACPFibroblast growth factor receptor 2/0.479
4nks2M2Fibroblast growth factor receptor 1/0.479
2py3ACPFibroblast growth factor receptor 2/0.478
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
3reyXACAdenosine receptor A2a/0.476
4c62XWWTyrosine-protein kinase JAK2/0.474
4f630S7Fibroblast growth factor receptor 1/0.474
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.474
2hziJINTyrosine-protein kinase ABL12.7.10.20.472
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.471
3p9tTCLRepressor/0.471
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.470
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.469
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.469
4jbtASDCytochrome P450 monooxygenase/0.469
2j7t274Serine/threonine-protein kinase 102.7.11.10.468
3p2oNADBifunctional protein FolD/0.468
3emlZMAAdenosine receptor A2a/0.468
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2vx17X8Ephrin type-B receptor 42.7.10.10.466
2ydoADNAdenosine receptor A2a/0.466
3gcq1BUMitogen-activated protein kinase 14/0.466
3vryB43Tyrosine-protein kinase HCK2.7.10.20.466
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.466
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2vwz7X6Ephrin type-B receptor 42.7.10.10.465
3zewSTUEphrin type-B receptor 42.7.10.10.465
1ove358Mitogen-activated protein kinase 14/0.464
3l8sBFFMitogen-activated protein kinase 14/0.464
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.464
4twnB96Ephrin type-A receptor 32.7.10.10.464
3qakUKAAdenosine receptor A2a/0.464
2of4979Tyrosine-protein kinase Lck2.7.10.20.463
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.463
2vx07X7Ephrin type-B receptor 42.7.10.10.463
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.463
2bujSTUSerine/threonine-protein kinase 16/0.462
3ac2KSETyrosine-protein kinase Lck2.7.10.20.462
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.462
1jlaTNKGag-Pol polyprotein2.7.7.490.461
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4az0S61Lysosomal protective protein3.4.16.50.461
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.461
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.461
4eevL1XHepatocyte growth factor receptor2.7.10.10.461
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.461
1o5rFR9Adenosine deaminase3.5.4.40.460
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.460
1y6bAAXVascular endothelial growth factor receptor 22.7.10.10.460
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.460
2vrbNAPTriphenylmethane reductase/0.460
2zb1GK4Mitogen-activated protein kinase 14/0.460
2ze2T27Gag-Pol polyprotein2.7.7.490.460
3h1jSMACytochrome b/0.460
3iw4LW4Protein kinase C alpha type2.7.11.130.460
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.459
2yixYIXMitogen-activated protein kinase 14/0.459
3a1l2CCCytochrome P450/0.459
3tamM06Gag-Pol polyprotein2.7.7.490.459
4gk2L66Ephrin type-A receptor 32.7.10.10.459
5e8xSTUTGF-beta receptor type-12.7.11.300.459
5iubCLRAdenosine receptor A2a/0.459
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.458
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.458
3bx5304Mitogen-activated protein kinase 14/0.458
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.458
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.457
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.457
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.457
3d75NBBPheromone-binding protein ASP1/0.457
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
4nk92K5Fibroblast growth factor receptor 1/0.457
1diuBDMDihydrofolate reductase1.5.1.30.456
1ly4COQDihydrofolate reductase1.5.1.30.456
1tvrTB9Gag-Pol polyprotein2.7.7.490.456
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2pzpACPFibroblast growth factor receptor 2/0.456
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.456
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3sfi3SFHTH-type transcriptional regulator EthR/0.456
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.456
4twpAXITyrosine-protein kinase ABL12.7.10.20.456
5i2hAGIO-methyltransferase family 2/0.456
5iu4ZMAAdenosine receptor A2a/0.456
5uviZMAAdenosine receptor A2a/0.456
2vcmM11Isopenicillin N synthase1.21.3.10.455
3njoPYVAbscisic acid receptor PYR1/0.455
4j6cSTRCytochrome P450 monooxygenase/0.455
3uzcT4EAdenosine receptor A2a/0.455
2bx8AZQSerum albumin/0.454
2hveADPNucleoside diphosphate kinase A2.7.4.60.454
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.454
3hv3R49Mitogen-activated protein kinase 14/0.454
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.454
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.454
4oavACP2-5A-dependent ribonuclease3.1.260.454
2hk51BMTyrosine-protein kinase HCK2.7.10.20.453
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.453
3d7zGK5Mitogen-activated protein kinase 14/0.453
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/0.452
2pwlACPFibroblast growth factor receptor 2/0.452
3ce31FNHepatocyte growth factor receptor2.7.10.10.452
3cneFMNPutative protease I/0.452
3f82353Hepatocyte growth factor receptor2.7.10.10.452
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.452
3s4qNK0Mitogen-activated protein kinase 14/0.452
4iebANPCalmodulin-domain protein kinase 1/0.452
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.451
1vruAAPGag-Pol polyprotein2.7.7.490.451
1zzlTZYMitogen-activated protein kinase 14/0.451
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.451
3bi6396Wee1-like protein kinase2.7.10.20.451
3l70JZVCytochrome b/0.451
3q0vLL4HTH-type transcriptional regulator EthR/0.451
3v1mHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.451
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
1pkfEPDEpothilone C/D epoxidase1.140.450
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2w3vTOPDihydrofolate reductase/0.450
3cr0809Wee1-like protein kinase2.7.10.20.450
3oom507Activin receptor type-12.7.11.300.450
3zeiAWHO-acetylserine sulfhydrylase/0.450
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.450
4j6dTESCytochrome P450 monooxygenase/0.450
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
5k2bZMAAdenosine receptor A2a/0.450
4ug2NGIAdenosine receptor A2a/0.450
1s1vTNKGag-Pol polyprotein2.7.7.490.449
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.449
2hamC33Vitamin D3 receptor/0.449
3e5aVX6Aurora kinase A2.7.11.10.449
3hp552PMitogen-activated protein kinase 14/0.449
3o8tBMUMitogen-activated protein kinase 14/0.449
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4qa2SHHHistone deacetylase 83.5.1.980.449
5iua6DXAdenosine receptor A2a/0.449
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.448
2ban357Gag-Pol polyprotein2.7.7.490.448
2ewaSB2Mitogen-activated protein kinase 14/0.448
2fziDH3Dihydrofolate reductase1.5.1.30.448
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.448
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.448
3iok1P6Tyrosine-protein kinase JAK2/0.448
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.448
4k9yK9YFocal adhesion kinase 12.7.10.20.448
4qa0SHHHistone deacetylase 83.5.1.980.448
5k2dZMAAdenosine receptor A2a/0.448
3rfmCFFAdenosine receptor A2a/0.448
1dajMOTDihydrofolate reductase1.5.1.30.447
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1p93DEXGlucocorticoid receptor/0.447
1u80C5PCoenzyme A biosynthesis bifunctional protein CoaBC6.3.2.50.447
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.447
3b7dCNIGlutamate receptor 2/0.447
3cd2MTXDihydrofolate reductase1.5.1.30.447
3dt1P40Mitogen-activated protein kinase 14/0.447
3med65BGag-Pol polyprotein2.7.7.490.447
4equG6ISerine/threonine-protein kinase 102.7.11.10.447
4kd79DRDihydrofolate reductase1.5.1.30.447
1lriCLRBeta-elicitin cryptogein/0.446
1qvnFRIInterleukin-2/0.446
2y6o1N1Ephrin type-A receptor 42.7.10.10.446
3l0lHC3Nuclear receptor ROR-gamma/0.446
3nwlNDPCatalase1.11.1.60.446
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.446
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.446
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.446
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1sqvUHDCytochrome b/0.445
1u4dDBQActivated CDC42 kinase 1/0.445
2c31ADPOxalyl-CoA decarboxylase4.1.1.80.445
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.445
2yac937Serine/threonine-protein kinase PLK12.7.11.210.445
2z3uCRRCytochrome P450/0.445
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.445
3dkoIHZEphrin type-A receptor 72.7.10.10.445
3w2cN15Aurora kinase A2.7.11.10.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.445
4id5T27Gag-Pol polyprotein2.7.7.490.445
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.445
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.444
2acwUPGGlycosyltransferase/0.444
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.444
2qo9ANPEphrin type-A receptor 32.7.10.10.444
2ydvNECAdenosine receptor A2a/0.444
3fhxPXLPyridoxal kinase2.7.1.350.444
3ipq965Oxysterols receptor LXR-alpha/0.444
4a9hTVPBromodomain-containing protein 2/0.444
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.444
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
8catNDPCatalase1.11.1.60.444
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3iw8HIZMitogen-activated protein kinase 14/0.443
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.443
3t195MAGag-Pol polyprotein2.7.7.490.443
3vt7VDXVitamin D3 receptor/0.443
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.443
4elb34RDihydrofolate reductase/0.443
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4g1qT27Gag-Pol polyprotein2.7.7.490.443
4ia1BIVVitamin D3 receptor A/0.443
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.443
5hbsRTLRetinol-binding protein 1/0.443
1di8DTQCyclin-dependent kinase 22.7.11.220.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.442
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1tl3H20Gag-Pol polyprotein2.7.7.490.442
1trgCB3Thymidylate synthase/0.442
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
2of2547Tyrosine-protein kinase Lck2.7.10.20.442
2wksCB63-dehydroquinate dehydratase4.2.1.100.442
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.442
3dyaPZLGag-Pol polyprotein2.7.7.490.442
3hx4ANPCalmodulin-domain protein kinase 1/0.442
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.442
3vjoANPEpidermal growth factor receptor2.7.10.10.442
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.442
4nc3ERM5-hydroxytryptamine receptor 2B/0.442
4tqqUQ1Reaction center protein L chain/0.442
1ep4S11Gag-Pol polyprotein2.7.7.490.441
1p33MTXPteridine reductase 11.5.1.330.441
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.441
2hb7O1CVitamin D3 receptor/0.441
2in6839Wee1-like protein kinase2.7.10.20.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.441
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.441
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.441
4hvg19QTyrosine-protein kinase JAK32.7.10.20.441
1mb9ATPCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.440
1mc5AHEAlcohol dehydrogenase class-31.1.1.10.440
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2p4yC03Peroxisome proliferator-activated receptor gamma/0.440
3ac1KZITyrosine-protein kinase Lck2.7.10.20.440
3fraI2HDihydrofolate reductase1.5.1.30.440
3p6nDSOCamphor 5-monooxygenase1.14.15.10.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
3q5iANPProtein kinase, putative/0.440
3qlhT27Gag-Pol polyprotein2.7.7.490.440
3r6pA8SAbscisic acid receptor PYL10/0.440
3vg9ZMAAdenosine receptor A2a/0.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4elf35IDihydrofolate reductase/0.440
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.440
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440