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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2og81N8Tyrosine-protein kinase Lck2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2og81N8Tyrosine-protein kinase Lck2.7.10.21.000
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.524
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.518
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.515
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.514
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.498
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.494
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.488
3lfbZ87Mitogen-activated protein kinase 14/0.487
3hng8STVascular endothelial growth factor receptor 12.7.10.10.481
2hyySTITyrosine-protein kinase ABL12.7.10.20.479
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.478
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.468
3ctj320Hepatocyte growth factor receptor2.7.10.10.466
3hv5R24Mitogen-activated protein kinase 14/0.466
4kaoKAOFocal adhesion kinase 12.7.10.20.466
1iepSTITyrosine-protein kinase ABL12.7.10.20.463
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.458
4o2z046Mitogen-activated protein kinase/0.458
3eta351Insulin receptor2.7.10.10.453
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.449
3efl706Vascular endothelial growth factor receptor 22.7.10.10.449
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.447
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.443
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.443