sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2o7p | NAP | Riboflavin biosynthesis protein RibD |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 1.000 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.493 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.470 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.466 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.464 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.463 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.461 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.459 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.457 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.456 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.455 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.453 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.452 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3bhr | THG | Thymidylate synthase | / | 0.451 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.449 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.448 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.445 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.445 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.445 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.444 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.444 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.442 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.440 | |
| 4phl | PIL | Phosphodiesterase | / | 0.440 | |
| 5dp2 | NAP | CurF | / | 0.440 |