sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2o6h	INI	6,7-dimethyl-8-ribityllumazine synthase 1	2.5.1.78

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2o6h	INI	6,7-dimethyl-8-ribityllumazine synthase 1	2.5.1.78	1.000
2vi5	Y19	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.496
1w19	T5P	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.463
1w19	T4P	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.463
1w29	TS0	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.460
2a57	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.444
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.440
2c94	TSF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.440