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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2o65MYFSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2o65MYFSerine/threonine-protein kinase pim-12.7.11.11.000
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.614
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.603
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.592
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.589
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.588
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.587
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.586
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.586
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.569
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.565
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.562
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.561
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.560
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.558
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.557
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.550
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.550
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.548
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.547
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.545
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.545
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.539
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.537
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.535
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.534
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.533
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.533
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.528
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.525
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.524
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.523
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.522
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.521
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.519
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.517
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.515
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.511
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.511
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.510
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.507
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.502
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.500
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.500
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.498
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.494
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.492
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.488
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.487
3iw4LW4Protein kinase C alpha type2.7.11.130.486
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.486
2xa4AZ5Tyrosine-protein kinase JAK2/0.483
1xjdSTUProtein kinase C theta type2.7.11.130.480
4othDRNSerine/threonine-protein kinase N1/0.479
1x2hLPALipoate-protein ligase A6.3.1.200.476
3oom507Activin receptor type-12.7.11.300.475
1q1rFADPutidaredoxin reductase1.18.1.50.474
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.472
3a4pDFQHepatocyte growth factor receptor2.7.10.10.471
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.470
2xikJ60Serine/threonine-protein kinase 252.7.11.10.470
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.469
4i22IREEpidermal growth factor receptor2.7.10.10.468
4dymIYZActivin receptor type-12.7.11.300.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.466
4bgg844Activin receptor type-12.7.11.300.466
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.466
2wedPP6Penicillopepsin-13.4.23.200.465
3be9P04Casein kinase II subunit alpha2.7.11.10.465
5cvhADPCasein kinase II subunit alpha2.7.11.10.465
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.464
3umw596Serine/threonine-protein kinase pim-12.7.11.10.464
2jedLG8Protein kinase C theta type2.7.11.130.463
4gmy0X5Tyrosine-protein kinase JAK2/0.463
2wihP48Cyclin-dependent kinase 22.7.11.220.462
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.460
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.460
3wmxNADNAD dependent epimerase/dehydratase/0.459
4c02TAKActivin receptor type-12.7.11.300.459
3vt7VDXVitamin D3 receptor/0.458
1u4dDBQActivated CDC42 kinase 1/0.457
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.456
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.456
4dgo0JWCasein kinase II subunit alpha2.7.11.10.456
4fob0USALK tyrosine kinase receptor2.7.10.10.456
2itpAEEEpidermal growth factor receptor2.7.10.10.455
4jia1K3Tyrosine-protein kinase JAK2/0.455
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.454
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.454
5auxKMPDeath-associated protein kinase 12.7.11.10.454
1m2pHNACasein kinase II subunit alpha2.7.11.10.453
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
3vetADPnebramycin 5' synthase6.1.2.20.452
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.452
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.451
4wboANWRhodopsin kinase/0.451
1u54ACPActivated CDC42 kinase 1/0.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.450
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.450
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.450
5auwQUEDeath-associated protein kinase 12.7.11.10.450
3du8553Glycogen synthase kinase-3 beta2.7.11.260.449
3nga3NGCasein kinase II subunit alpha2.7.11.10.449
4gg70J8Hepatocyte growth factor receptor2.7.10.10.449
1vjy460TGF-beta receptor type-12.7.11.300.448
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.448
1aq1STUCyclin-dependent kinase 22.7.11.220.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
4a86H35Major pollen allergen Bet v 1-A/0.447
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.447
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.447
2j0lANPFocal adhesion kinase 12.7.10.20.446
2x7gPVBSRSF protein kinase 22.7.11.10.446
3q9xEMOCasein kinase II subunit alpha2.7.11.10.446
4mwhATPCasein kinase II subunit alpha2.7.11.10.446
1lp4ANPCasein kinase II subunit alpha2.7.11.10.445
1ppm0P1Penicillopepsin-13.4.23.200.445
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1wvxBD4Death-associated protein kinase 12.7.11.10.445
2h96893Mitogen-activated protein kinase 82.7.11.240.445
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.445
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.445
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.445
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3b7dCNIGlutamate receptor 2/0.444
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.444
4jq8KJ8Epidermal growth factor receptor2.7.10.10.444
1c6yMK1Protease/0.443
5auuLU2Death-associated protein kinase 12.7.11.10.443
1e9hINRCyclin-dependent kinase 22.7.11.220.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
2xnbY8LCyclin-dependent kinase 22.7.11.220.442
3bu5ATPInsulin receptor2.7.10.10.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5auvAGIDeath-associated protein kinase 12.7.11.10.442
5av2KMPDeath-associated protein kinase 12.7.11.10.442
1bxoPP7Penicillopepsin-13.4.23.200.441
2pmoHMDProtein kinase 7/0.441
2wecPP5Penicillopepsin-13.4.23.200.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.441
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.440
2cchATPCyclin-dependent kinase 22.7.11.220.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2uxpCLMHTH-type transcriptional regulator TtgR/0.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440