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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.11.000
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.568
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.465
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.440