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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2mscGDPMHC class I alpha chain

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2mscGDPMHC class I alpha chain/1.000
4lpkGDPGTPase KRas/0.571
4wa7GDPGTPase KRas/0.561
4l9sGDPGTPase HRas/0.552
2msdGNPMHC class I alpha chain/0.551
3kkqGDPRas-related protein M-Ras/0.542
4tq9GDPGTPase KRas/0.536
4hdqGNPRas-related protein Rap-1b/0.529
1pd9CO4Dihydrofolate reductase1.5.1.30.524
4lucGDPGTPase KRas/0.524
4o2rGDPGTP-binding protein Rheb/0.521
2mseGNPMHC class I alpha chain/0.520
4epwGDPGTPase KRas/0.518
4l8gGDPGTPase KRas/0.517
3tgpGNPGTPase HRas/0.512
4ql3GDPGTPase KRas/0.512
1drfFOLDihydrofolate reductase1.5.1.30.507
2ce2GDPGTPase HRas/0.507
1s3uTQDDihydrofolate reductase1.5.1.30.506
2rggGNPGTPase HRas/0.506
3kkoGNPRas-related protein M-Ras/0.503
4lrwGDPGTPase KRas/0.503
4xvrGNPGTPase HRas/0.503
1x1rGDPRas-related protein M-Ras/0.501
4obeGDPGTPase KRas/0.501
1m78NDPDihydrofolate reductase1.5.1.30.500
3k9lGNPGTPase HRas/0.500
4q02GDPGTPase KRas/0.500
2dhfDZFDihydrofolate reductase1.5.1.30.499
4xvqGNPGTPase HRas/0.499
1pqc444Oxysterols receptor LXR-beta/0.497
4lv6GDPGTPase KRas/0.497
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
2fg5GNPRas-related protein Rab-31/0.495
1mvtDTMDihydrofolate reductase1.5.1.30.494
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.494
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.492
2rgeGNPGTPase HRas/0.490
4epxGDPGTPase KRas/0.490
4ldjGDPGTPase KRas/0.490
3mjhGTPRas-related protein Rab-5A/0.489
3v4fGNPGTPase HRas/0.489
4q03GDPGTPase KRas/0.489
4lb2DM5Serum albumin/0.487
1ia1NDPDihydrofolate reductase1.5.1.30.486
1yu9GNPRas-related protein Rab-4A/0.486
1z7yAA5Cysteine synthase 12.5.1.470.486
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.486
1g16GDPRas-related protein SEC4/0.485
3ewsADPATP-dependent RNA helicase DDX19B3.6.4.130.484
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
1kceCB3Thymidylate synthase/0.483
1mvsDTMDihydrofolate reductase1.5.1.30.483
2c29NAPDihydroflavonol 4-reductase/0.483
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
2o4rVD5Vitamin D3 receptor/0.481
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.480
4tuvCPZCytochrome P450 1191.140.480
1dhrNADDihydropteridine reductase1.5.1.340.479
1rx8NAPDihydrofolate reductase1.5.1.30.479
2rgbGNPGTPase HRas/0.479
2wetFADTryptophan 5-halogenase/0.479
1drhNAPDihydrofolate reductase1.5.1.30.478
1jq5NADGlycerol dehydrogenase1.1.1.60.478
3rs0GNPGTPase HRas/0.478
4a802ANMajor pollen allergen Bet v 1-A/0.478
4g95OAGDihydrofolate reductase1.5.1.30.478
4nyjGNPGTPase HRas/0.478
3phiNDPShikimate dehydrogenase (NADP(+))/0.477
1poxFADPyruvate oxidase1.2.3.30.476
2bmeGNPRas-related protein Rab-4A/0.476
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
2rgcGNPGTPase HRas/0.476
2yg4FADPutrescine oxidase/0.476
3sn6P0GBeta-2 adrenergic receptor/0.476
3pitGNPRas-related protein M-Ras/0.475
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.475
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
3ddcGNPGTPase HRas/0.474
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.474
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.473
3gtsD3MDdmC/0.473
3r5yF42Uncharacterized protein/0.473
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.473
2dw4FADLysine-specific histone demethylase 1A10.472
3lbhGNPGTPase HRas/0.472
3s55NADPutative short-chain dehydrogenase/reductase/0.472
4abkAR6Poly [ADP-ribose] polymerase 142.4.2.300.472
4m6jNDPDihydrofolate reductase1.5.1.30.472
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.471
2o2yTCLEnoyl-ACP reductase/0.471
3c3dFO12-phospho-L-lactate transferase/0.471
3nxxNDPDihydrofolate reductase1.5.1.30.471
3rgaILDEpoxide hydrolase LasB5.5.10.471
3x1zGNPRas-related protein Rap-1b/0.471
1kzjCB3Thymidylate synthase/0.470
2c2aADPSensor histidine kinase/0.470
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.470
4dsnGCPGTPase KRas/0.470
4r1lADPPhenylacetate-coenzyme A ligase/0.470
1fwkADPHomoserine kinase2.7.1.390.469
1r2jFADFkbI/0.469
2fonFADAcyl-coenzyme A oxidase/0.469
2o2sTCLEnoyl-acyl carrier reductase/0.469
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.469
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.469
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.469
1s1cGNPTransforming protein RhoA/0.468
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.468
4mzuCOAWxcM-like protein/0.468
4rheFMNFlavin prenyltransferase UbiX/0.468
1pq944BOxysterols receptor LXR-beta/0.467
1qo8FADFumarate reductase flavoprotein subunit/0.467
2ardFDAFlavin-dependent tryptophan halogenase PrnA1.14.19.90.467
2fe4GDPRas-related protein Rab-6B/0.467
2fznFADBifunctional protein PutA1.5.5.20.467
3qwbNDPProbable quinone oxidoreductase1.6.5.50.467
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.467
3w0iO11Vitamin D3 receptor/0.467
4dlxGNPGTPase HRas/0.467
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.467
1ai9NDPDihydrofolate reductase1.5.1.30.466
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.466
2z6jTUI2-nitropropane dioxygenase/0.466
3a6pGTPGTP-binding nuclear protein Ran/0.466
3d84NDPDihydrofolate reductase1.5.1.30.466
3oiuGNPGTPase HRas/0.466
3wagTYDGlycosyltransferase/0.466
3x2fNAIAdenosylhomocysteinase/0.466
4nbwNADShort-chain dehydrogenase/reductase SDR/0.466
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.466
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
4nyiGNPGTPase HRas/0.465
4q73FADBifunctional protein PutA/0.465
1eiiRTLRetinol-binding protein 2/0.464
1n83CLRNuclear receptor ROR-alpha/0.464
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
4jq3NAPAldo-keto reductase family 1 member C2/0.464
2rc4ACOHistone acetyltransferase KAT6A/0.463
2zawCAMCamphor 5-monooxygenase1.14.15.10.463
4a4zANPAntiviral helicase SKI23.6.4.130.463
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.463
4dbzNDPPutative ketoacyl reductase1.3.10.463
4dlzGNPGTPase HRas/0.463
1kvkATPMevalonate kinase2.7.1.360.462
1uh5TCLEnoyl-ACP reductase/0.462
1y4lSVRBasic phospholipase A2 homolog 2/0.462
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2q9fC3SCholesterol 24-hydroxylase/0.462
2zfq45UProthrombin3.4.21.50.462
3am5TCLEnoyl-ACP reductase/0.462
3cphGDPRas-related protein SEC4/0.462
3eluSAMMethyltransferase/0.462
3maaFKPAdenylate cyclase type 2/0.462
3maaFKPAdenylate cyclase type 5/0.462
3qlsNDPDihydrofolate reductase1.5.1.30.462
3rs5GNPGTPase HRas/0.462
4c73TLH3-oxoacyl-ACP synthase/0.462
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.462
1yrdCAMCamphor 5-monooxygenase1.14.15.10.461
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.461
3uylTYDProbable NDP-rhamnosyltransferase/0.461
4g0nGNPGTPase HRas/0.461
4zm6ACON-acetyl-beta-D glucosaminidase/0.461
1dr2TAPDihydrofolate reductase1.5.1.30.460
1dz8CAMCamphor 5-monooxygenase1.14.15.10.460
1s3vTQDDihydrofolate reductase1.5.1.30.460
1xe65FPPlasmepsin-23.4.23.390.460
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.460
4j49NAIUncharacterized protein/0.460
1ae1NAPTropinone reductase 1/0.459
1dr3TAPDihydrofolate reductase1.5.1.30.459
1dr3HBIDihydrofolate reductase1.5.1.30.459
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2djiFADPyruvate oxidase/0.459
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.459
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.459
3koo24DBifunctional epoxide hydrolase 23.3.2.100.459
3oiwGNPGTPase HRas/0.459
3tfyCOAN-alpha-acetyltransferase 502.3.10.459
3tqaNDPDihydrofolate reductase/0.459
4bixADPSensor histidine kinase CpxA/0.459
4dlvGNPGTPase HRas/0.459
4k6fNAPPutative Acetoacetyl-CoA reductase/0.459
1c5nESIProthrombin3.4.21.50.458
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.458
2op07PCEnoyl-ACP reductase/0.458
2w9hTOPDihydrofolate reductase1.5.1.30.458
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3jynNDPQuinone oxidoreductase/0.458
3k8yGNPGTPase HRas/0.458
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.458
3rs4GNPGTPase HRas/0.458
4iteTEYVitamin D3 receptor/0.458
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2wesFADTryptophan 5-halogenase/0.457
3i3sGNPGTPase HRas/0.457
3oivGNPGTPase HRas/0.457
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.457
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.457
1n6lGTPRas-related protein Rab-5A/0.456
1zsnTN2Enoyl-ACP reductase/0.456
2rewREWPeroxisome proliferator-activated receptor alpha/0.456
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3nr4PYVAbscisic acid receptor PYL2/0.456
3p3zP3ZPutative cytochrome P450/0.456
4l4eCAMCamphor 5-monooxygenase1.14.15.10.456
5eccNAPDehydrofolate reductase type I/0.456
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1d3dBZTProthrombin3.4.21.50.455
1nvmNADAcetaldehyde dehydrogenase1.2.1.100.455
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.455
1tduDURThymidylate synthase/0.455
2j7pGNPSignal recognition particle protein/0.455
2j7pGNPSignal recognition particle receptor FtsY/0.455
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.455
5hy5FADTryptophan 6-halogenase/0.455
5iu86DZAdenosine receptor A2a/0.455
1exa394Retinoic acid receptor gamma/0.454
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.454
1t3r017Gag-Pol polyprotein3.4.23.160.454
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.454
2bxmIMNSerum albumin/0.454
2f80017Gag-Pol polyprotein3.4.23.160.454
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.454
2z4y252Geranylgeranyl pyrophosphate synthase/0.454
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
3q9oNADCholix toxin2.4.2.360.454
3wrmCAMCamphor 5-monooxygenase1.14.15.10.454
2abbFMNPentaerythritol tetranitrate reductase/0.453
2bsxNOSPurine nucleoside phosphorylase/0.453
2c3p1TPPyruvate synthase/0.453
2w3bNDPDihydrofolate reductase1.5.1.30.453
3ak4NADNADH-dependent quinuclidinone reductase/0.453
3br3ETHTH-type transcriptional regulator QacR/0.453
3iltTRUGlutamate receptor 2/0.453
3kucGDPRas-related protein Rap-1A/0.453
3nj8NJ8Enoyl-acyl carrier reductase/0.453
4a81DXCMajor pollen allergen Bet v 1-A/0.453
4a83DXCMajor pollen allergen Bet v 1-A/0.453
4uyg73BBromodomain-containing protein 2/0.453
1dg8NDPDihydrofolate reductase1.5.1.30.452
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.452
1osvCHCBile acid receptor/0.452
1xny191Propionyl-CoA carboxylase complex B subunit/0.452
2bbqPFGThymidylate synthase/0.452
2xvv9DNSerum albumin/0.452
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.452
3cntFADPolyamine oxidase FMS1/0.452
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.452
3n0hTOPDihydrofolate reductase1.5.1.30.452
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.452
4zvlFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.452
1diuBDMDihydrofolate reductase1.5.1.30.451
1ie8KH1Vitamin D3 receptor/0.451
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.451
2cig1DGDihydrofolate reductase1.5.1.30.451
2hqpNDPDihydrofolate reductase1.5.1.30.451
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3ipq965Oxysterols receptor LXR-alpha/0.451
3toxNAPPutative oxidoreductase/0.451
3w5p4OAVitamin D3 receptor/0.451
4a84DXCMajor pollen allergen Bet v 1-A/0.451
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.451
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.451
4yp7NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.451
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
1powFADPyruvate oxidase1.2.3.30.450
1txiTX5Vitamin D3 receptor/0.450
1v4sMRKGlucokinase2.7.1.20.450
1xkdNAPIsocitrate dehydrogenase [NADP]/0.450
2rr1W8RGenome polyprotein/0.450
2xhd7T9Glutamate receptor 2/0.450
3aosJH2Hemolymph juvenile hormone binding protein/0.450
3fwjCAMCamphor 5-monooxygenase1.14.15.10.450
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.450
3gl2D3MDdmC/0.450
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3nn6HNK6-hydroxy-L-nicotine oxidase/0.450
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.450
3znqSS8D-amino-acid oxidase1.4.3.30.450
4c72TLG3-oxoacyl-ACP synthase/0.450
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.450
4y1bNAPAntE/0.450
1bsvNDPGDP-L-fucose synthase/0.449
1kt7RTLRetinol-binding protein 4/0.449
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.449
1ot7CHCBile acid receptor/0.449
1s0xC3SNuclear receptor ROR-alpha/0.449
1tl7FOKAdenylate cyclase type 2/0.449
1tl7FOKAdenylate cyclase type 5/0.449
1upw444Oxysterols receptor LXR-beta/0.449
1zc4GNPRas-related protein Ral-A/0.449
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.449
2np6NEAModification methylase TaqI2.1.1.720.449
2yj4ATPCopper-transporting ATPase/0.449
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3qlrNDPDihydrofolate reductase1.5.1.30.449
3vaqADNPutative adenosine kinase/0.449
3w0hW12Vitamin D3 receptor/0.449
4i3vNADAldehyde dehydrogenase (NAD+)/0.449
4ia3BIVVitamin D3 receptor A/0.449
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.449
4imfSI3N-acetylneuraminate lyase/0.449
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.449
4r20AERCytochrome P450 family 17 polypeptide 2/0.449
1dhfFOLDihydrofolate reductase1.5.1.30.448
1hdoNAPFlavin reductase (NADPH)/0.448
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.448
1xjjDGTVitamin B12-dependent ribonucleotide reductase/0.448
1xpqFADPolyamine oxidase FMS1/0.448
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.448
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.448
2jahNDPClavaldehyde dehydrogenase/0.448
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2xpuTDCTetracycline repressor protein class D/0.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3gkjHC3Niemann-Pick C1 protein/0.448
3s7a684Dihydrofolate reductase1.5.1.30.448
3vruYS3Vitamin D3 receptor/0.448
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4epq0RRPoly(ADP-ribose) glycohydrolase/0.448
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.448
4mitGTPRho-related protein racC/0.448
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.448
4z28BTNHoefavidin/0.448
1nhgTCLEnoyl-ACP reductase/0.447
1nytNAPShikimate dehydrogenase (NADP(+))/0.447
1pkfEPDEpothilone C/D epoxidase1.140.447
1zw1TN5Enoyl-ACP reductase/0.447
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.447
2e48FADD-amino-acid oxidase1.4.3.30.447
2nvbNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.447
2q4wFADCytokinin dehydrogenase 71.5.99.120.447
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
3oafOAGDihydrofolate reductase1.5.1.30.447
3q9tFAYUncharacterized protein/0.447
3t8vBTJM1 family aminopeptidase3.4.110.447
3w8fNAD3-hydroxybutyrate dehydrogenase/0.447
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.447
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.447
4irnFADAnaB/0.447
4knzCB3Thymidylate synthase/0.447
4n4t2GVTankyrase-12.4.2.300.447
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
4k5y1Q5Corticotropin-releasing factor receptor 1/0.447
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.446
1tj0FADBifunctional protein PutA1.5.5.20.446
1yzqGNPRas-related protein Rab-6A/0.446
2ozuACOHistone acetyltransferase KAT6A/0.446
2qw8NAPEugenol synthase 11.1.1.3180.446
3ghvGHCDihydrofolate reductase1.5.1.30.446
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3lsyFT0Enoyl-ACP reductase/0.446
3o0qADNVitamin B12-dependent ribonucleotide reductase/0.446
3owaFADAcyl-CoA dehydrogenase/0.446
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
3s3vTOPDihydrofolate reductase1.5.1.30.446
3stv3HOMethylketone synthase I/0.446
3vydVYDRenin3.4.23.150.446
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
4dlsGNPGTPase HRas/0.446
4udqFAD5-(hydroxymethyl)furfural oxidase/0.446
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1nooCAHCamphor 5-monooxygenase1.14.15.10.445
1pvgANPDNA topoisomerase 25.99.1.30.445
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.445
1rx1NAPDihydrofolate reductase1.5.1.30.445
1ygjRMCPyridoxal kinase2.7.1.350.445
2i4qUA4Renin3.4.23.150.445
2o7pNAPRiboflavin biosynthesis protein RibD/0.445
2ok7FADFerredoxin--NADP reductase, apicoplast/0.445
2rqfJH3Hemolymph juvenile hormone binding protein/0.445
2ywlFADThioredoxin reductase related protein/0.445
3aygHQONitric oxide reductase/0.445
3gnvXNZGenome polyprotein2.7.7.480.445
3h3sH15Collagen type IV alpha-3-binding protein/0.445
3uxyNADShort-chain dehydrogenase/reductase SDR/0.445
3zeiAWHO-acetylserine sulfhydrylase/0.445
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.445
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.445
4xo7NAPAldo-keto reductase family 1 member C2/0.445
4y8wSTRSteroid 21-hydroxylase/0.445
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
5emhNAPIridoid synthase1.3.1.990.445
5i2hAGIO-methyltransferase family 2/0.445
5idwNAPShort-chain dehydrogenase/reductase SDR/0.445
1lfdGNPGTPase HRas/0.444
1mj9COAHistone acetyltransferase ESA1/0.444
1pjkANPCasein kinase II subunit alpha2.7.11.10.444
1t4v14AProthrombin3.4.21.50.444
1trgCB3Thymidylate synthase/0.444
1vpmCOAAcyl-CoA hydrolase/0.444
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.444
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2cppCAMCamphor 5-monooxygenase1.14.15.10.444
2ou2ACOHistone acetyltransferase KAT5/0.444
2p1v5TNRetinoic acid receptor RXR-alpha/0.444
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.444
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3icsADPCoenzyme A disulfide reductase/0.444
3k7mFAD6-hydroxy-L-nicotine oxidase/0.444
3lxiCAMCytochrome P450/0.444
3mohGDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.444
3nu3478Gag-Pol polyprotein3.4.23.160.444
3rnnRNNGlutamate receptor 2/0.444
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.444
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
3wrhCAMCamphor 5-monooxygenase1.14.15.10.444
4a7b3W5Collagenase 33.4.240.444
4enhFVXCholesterol 24-hydroxylase/0.444
4g1y0VOVitamin D3 receptor A/0.444
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
1dyiFOLDihydrofolate reductase1.5.1.30.443
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.443
1uvsI11Prothrombin3.4.21.50.443
1xnjADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.443
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.443
2j3nNAPThioredoxin reductase 1, cytoplasmic1.8.1.90.443
3bgxMEFThymidylate synthase/0.443
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.443
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3gvhNADMalate dehydrogenase/0.443
3iaeD7KBenzaldehyde lyase/0.443
3wqmB29Diterpene synthase3.1.7.80.443
4bzqADPBifunctional enzyme CysN/CysC2.7.1.250.443
4fhi0S4Vitamin D3 receptor A/0.443
4gh5NADShort-chain dehydrogenase/reductase SDR/0.443
4gqe6KJNitric oxide synthase, brain1.14.13.390.443
4ocvANPAminoglycoside phosphotransferase/0.443
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.443
4xbfFADLysine-specific histone demethylase 1A10.443
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.443
5es7FONLinear gramicidin synthase subunit A/0.443
5jlaNADPutative short-chain dehydrogenase/reductase/0.443
1dgmADNAdenosine kinase2.7.1.200.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1v5eFADPyruvate oxidase/0.442
2bf7HBIPteridine reductase 11.5.1.330.442
2ftoCB3Thymidylate synthase/0.442
2g1s4IGRenin3.4.23.150.442
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2nq8ZIDEnoyl-ACP reductase/0.442
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3drcMTXDihydrofolate reductase1.5.1.30.442
3ekuCY9Actin-5C/0.442
3fp0FP015-O-acetyltransferase/0.442
3ixp834Ecdysone receptor/0.442
3jv7NADSecondary alcohol dehydrogenase/0.442
3l63CAMCamphor 5-monooxygenase1.14.15.10.442
3nt6COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.442
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3r5zF42Uncharacterized protein/0.442
3vt7VDXVitamin D3 receptor/0.442
4a5lNDPThioredoxin reductase/0.442
4d5gFADCyclohexane-1,2-dione hydrolase3.7.1.110.442
4g210VPVitamin D3 receptor A/0.442
4hw219HInduced myeloid leukemia cell differentiation protein Mcl-1/0.442
4o2lGTPGTP-binding protein Rheb/0.442
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
1a4rGNHCell division control protein 42 homolog/0.441
1bq1CB3Thymidylate synthase/0.441
1dr5NAPDihydrofolate reductase1.5.1.30.441
1geeNADGlucose 1-dehydrogenase1.1.1.470.441
1ia4TQ6Dihydrofolate reductase1.5.1.30.441
1pr9NAPL-xylulose reductase1.1.1.100.441
1rb2FOLDihydrofolate reductase1.5.1.30.441
2du8FADD-amino-acid oxidase1.4.3.30.441
2eeqSAHDiphthine synthase/0.441
2f3rG5PGuanylate kinase2.7.4.80.441
2i0dMUTProtease/0.441
2rm2W43Genome polyprotein/0.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2yg7FADPutrescine oxidase/0.441
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.441
3fl9TOPDihydrofolate reductase/0.441
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3o9cK20Pol polyprotein/0.441
3o9gF53Gag-Pol polyprotein/0.441
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
3vt3VDXVitamin D3 receptor/0.441
3vt5YI2Vitamin D3 receptor/0.441
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.441
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.441
4jlj1NMDeoxycytidine kinase2.7.1.740.441
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.441
4ure1PSCyclohexanol dehydrogenase/0.441
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
4ztvTA7Anthranilate phosphoribosyltransferase/0.441
5a3cNADSIR2 family protein/0.441
5dbfNDPIridoid synthase1.3.1.990.441
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.440
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.440
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1hb1OCVIsopenicillin N synthase1.21.3.10.440
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.440
1kt3RTLRetinol-binding protein 4/0.440
1og5SWFCytochrome P450 2C9/0.440
2a1oCAMCamphor 5-monooxygenase1.14.15.10.440
2b4yAPRNAD-dependent protein deacylase sirtuin-5, mitochondrial/0.440
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.440
2qo9ANPEphrin type-A receptor 32.7.10.10.440
2rd2QSIGlutamine--tRNA ligase6.1.1.180.440
2rgoFADAlpha-Glycerophosphate Oxidase/0.440
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.440
3ai3NDPNADPH-sorbose reductase/0.440
3akm11DFatty acid-binding protein, intestinal/0.440
3fhxPLPPyridoxal kinase2.7.1.350.440
3icpNADNAD-dependent epimerase/dehydratase/0.440
3ik6HCZGlutamate receptor 2/0.440
3ko8NADNAD-dependent epimerase/dehydratase/0.440
3otwCOAPhosphopantetheine adenylyltransferase/0.440
3up0D7SaceDAF-12/0.440
4dlwGNPGTPase HRas/0.440
4lcjNADC-terminal-binding protein 2/0.440
4psbGA3Cytokinin-specific binding protein/0.440
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.440
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.440
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.440