sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2l98 | STL | Troponin C, slow skeletal and cardiac muscles |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2l98 | STL | Troponin C, slow skeletal and cardiac muscles | / | 1.000 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.504 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.503 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.498 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.495 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.494 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.490 | |
| 3p9t | TCL | Repressor | / | 0.484 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.483 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.482 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.481 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.480 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.478 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.477 | |
| 1err | RAL | Estrogen receptor | / | 0.475 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.475 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.475 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.475 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.475 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.474 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.473 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.472 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.471 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.471 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.471 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.471 | |
| 1kb9 | SMA | Cytochrome b | / | 0.470 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.470 | |
| 3cxh | SMA | Cytochrome b | / | 0.470 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.469 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.469 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.469 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.468 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.468 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.468 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.468 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.467 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.467 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.467 | |
| 2acw | UPG | Glycosyltransferase | / | 0.466 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.466 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.465 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1fec | FAD | Trypanothione reductase | 1.8.1.12 | 0.464 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.464 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 3cx5 | SMA | Cytochrome b | / | 0.463 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.463 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.462 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.462 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.462 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.461 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.460 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.460 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.460 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.460 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.460 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.459 | |
| 1r9o | FLP | Cytochrome P450 2C9 | / | 0.459 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.459 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.459 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.458 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.458 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.458 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.458 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.457 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.457 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1e7a | PFL | Serum albumin | / | 0.456 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.456 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.456 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.456 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.456 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.455 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.455 | |
| 1td2 | PXL | Pyridoxal kinase PdxY | / | 0.455 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.455 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.455 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.455 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.455 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.455 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.454 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.454 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.454 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.454 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.454 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.453 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.453 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.453 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.452 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 1sj0 | E4D | Estrogen receptor | / | 0.451 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.451 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.451 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3q30 | D61 | Squalene synthase | 2.5.1.21 | 0.451 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.451 | |
| 4pv5 | CBW | Lactoylglutathione lyase | 4.4.1.5 | 0.451 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.451 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.450 | |
| 1jut | LYD | Thymidylate synthase | / | 0.450 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.450 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.450 | |
| 4hxs | 1A3 | Bromodomain-containing protein 4 | / | 0.450 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.449 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.449 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2p15 | EZT | Estrogen receptor | / | 0.449 | |
| 3bac | 3B9 | DNA ligase | / | 0.449 | |
| 3dol | GWI | Pol protein | / | 0.449 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.449 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1ezv | SMA | Cytochrome b | / | 0.448 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.448 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.448 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.448 | |
| 3aba | FLI | Cytochrome P450 | / | 0.448 | |
| 3bej | MUF | Bile acid receptor | / | 0.448 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.448 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.447 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2imk | GTX | AGAP009194-PA | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.447 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.447 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.447 | |
| 1nde | MON | Estrogen receptor beta | / | 0.446 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.446 | |
| 1s1w | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3e7m | AT2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.446 | |
| 3q9o | NAD | Cholix toxin | 2.4.2.36 | 0.446 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.446 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1uom | PTI | Estrogen receptor | / | 0.445 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.445 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 3cse | N22 | Uncharacterized protein | / | 0.445 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.445 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.445 | |
| 3h18 | PMS | Esterase/lipase | / | 0.445 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.445 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1j3j | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 3anm | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.444 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.444 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 5k8b | PDG | 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase | / | 0.444 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.443 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 2vq5 | LDP | S-norcoclaurine synthase | / | 0.443 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.443 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.443 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.443 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.442 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3h1j | SMA | Cytochrome b | / | 0.442 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3qly | 55V | Uncharacterized protein | / | 0.442 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.442 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.442 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.442 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.442 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.442 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.442 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.441 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.441 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.441 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.441 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.441 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.441 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.441 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2bx8 | AZQ | Serum albumin | / | 0.440 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.440 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.440 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3htj | ET | EbrA repressor | / | 0.440 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.440 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.440 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 |