Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2k0gCMPCyclic nucleotide-gated potassium channel mll3241

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2k0gCMPCyclic nucleotide-gated potassium channel mll3241/1.000
2e15SAHDiphthine synthase/0.496
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
4i0aCMPcAMP-activated global transcriptional regulator CRP/0.493
3flwFLWMitogen-activated protein kinase 14/0.492
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.490
3cl1PCGCyclic nucleotide-gated potassium channel mll3241/0.490
2y05NAPProstaglandin reductase 1/0.489
2yxuATPPyridoxal kinase2.7.1.350.489
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.489
4q73FADBifunctional protein PutA/0.488
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.482
1ruoCMPcAMP-activated global transcriptional regulator CRP/0.482
3fwjCAMCamphor 5-monooxygenase1.14.15.10.482
1zrcCMPcAMP-activated global transcriptional regulator CRP/0.481
4i01CMPcAMP-activated global transcriptional regulator CRP/0.480
3u9eCOALmo1369 protein/0.479
4q72FADBifunctional protein PutA/0.479
3rouCMPcAMP-activated global transcriptional regulator CRP/0.478
4bfxZVXPantothenate kinase2.7.1.330.478
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.476
2gzwCMPcAMP-activated global transcriptional regulator CRP/0.475
3rypCMPcAMP-activated global transcriptional regulator CRP/0.475
3wmxNADNAD dependent epimerase/dehydratase/0.475
2oz6CMPCyclic AMP receptor-like protein/0.474
4ft8CMPcAMP-activated global transcriptional regulator CRP/0.474
4ienCOAPutative acyl-CoA hydrolase/0.474
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.473
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.473
4jl5ADPAdenylate kinase/0.472
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.471
2q5g1FAPeroxisome proliferator-activated receptor delta/0.469
2cbrA80Cellular retinoic acid-binding protein 1/0.468
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.468
3fskRO6Mitogen-activated protein kinase 14/0.468
3kb1ADPIron-sulfur cluster carrier protein/0.467
4i09CMPcAMP-activated global transcriptional regulator CRP/0.467
1i5zCMPcAMP-activated global transcriptional regulator CRP/0.466
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.466
1orrNADCDP-paratose 2-epimerase/0.465
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.465
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
4ig01FGGag-Pol polyprotein2.7.7.490.464
4xldBRLPeroxisome proliferator-activated receptor gamma/0.464
4y3jHICEndothiapepsin3.4.23.220.464
2znq401Peroxisome proliferator-activated receptor delta/0.463
3cbsR12Cellular retinoic acid-binding protein 2/0.462
4f650S9Fibroblast growth factor receptor 1/0.462
4ktc1X3Genome polyprotein3.4.21.980.462
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.461
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
3lqfNADGalactitol dehydrogenase/0.461
4nr42LKCREB-binding protein/0.461
1udaUFGUDP-glucose 4-epimerase5.1.3.20.460
2hr8SAHDiphthine synthase/0.460
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.460
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.460
2lfoGCHFatty acid-binding protein, liver/0.459
2p33J07Mitogen-activated protein kinase 102.7.11.240.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.459
3qopCMPcAMP-activated global transcriptional regulator CRP/0.459
4dzzADPPlasmid partitioning protein ParF/0.459
5uviZMAAdenosine receptor A2a/0.459
1u54ACPActivated CDC42 kinase 1/0.458
3n4mCMPcAMP-activated global transcriptional regulator CRP/0.458
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
4c59FEFCyclin-G-associated kinase2.7.11.10.458
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.458
1kkq471Peroxisome proliferator-activated receptor alpha/0.457
3t2yFADSulfide-quinone reductase/0.457
4hbnCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.457
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.457
1x2hLPALipoate-protein ligase A6.3.1.200.456
1xe55FEPlasmepsin-23.4.23.390.456
2b7aIZATyrosine-protein kinase JAK2/0.456
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.456
2xhd7T9Glutamate receptor 2/0.456
3fhyATPPyridoxal kinase2.7.1.350.456
4hzfCMPcAMP-activated global transcriptional regulator CRP/0.456
4jloADPAdenylate kinase/0.456
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.455
2gjnFMNNitronate monooxygenase1.13.12.160.455
2pvyACPFibroblast growth factor receptor 2/0.455
2znpK55Peroxisome proliferator-activated receptor delta/0.455
1jpaANPEphrin type-B receptor 22.7.10.10.454
1py5PY1TGF-beta receptor type-12.7.11.300.454
2briANPUridylate kinase2.7.4.220.454
2dsgSAHDiphthine synthase/0.454
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1cbsREACellular retinoic acid-binding protein 2/0.453
1tj2FADBifunctional protein PutA1.5.5.20.453
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.453
5hy5FADTryptophan 6-halogenase/0.453
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.452
1meiXMPInosine-5'-monophosphate dehydrogenase/0.452
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.452
1zrdCMPcAMP-activated global transcriptional regulator CRP/0.452
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.452
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.452
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.452
2w71L23Biotin carboxylase6.3.4.140.452
3eej53RUncharacterized protein/0.452
3r83Z14Cyclin-dependent kinase 22.7.11.220.452
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.452
4l4cCAMCamphor 5-monooxygenase1.14.15.10.452
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.451
1t87CAMCamphor 5-monooxygenase1.14.15.10.451
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.451
2ojg19AMitogen-activated protein kinase 12.7.11.240.451
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.451
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.450
2emuSAHDiphthine synthase/0.450
2fr3REACellular retinoic acid-binding protein 2/0.450
2nniMTKCytochrome P450 2C8/0.450
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.450
4hgs15GCasein kinase I isoform gamma-32.7.11.10.450
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.449
1tduDURThymidylate synthase/0.449
1udbUFGUDP-glucose 4-epimerase5.1.3.20.449
2cig1DGDihydrofolate reductase1.5.1.30.449
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.449
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.449
3poz03PEpidermal growth factor receptor2.7.10.10.449
3uyt0CKCasein kinase I isoform delta2.7.11.10.449
4c58824Cyclin-G-associated kinase2.7.11.10.449
4r20AERCytochrome P450 family 17 polypeptide 2/0.449
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.449
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1bwsNDPGDP-L-fucose synthase/0.448
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.448
2zjmF1MBeta-secretase 13.4.23.460.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3kccCMPcAMP-activated global transcriptional regulator CRP/0.448
3w78CBDFMN-dependent NADH-azoreductase/0.448
4c4jX21Dual specificity protein kinase TTK2.7.12.10.448
4ki8ADP60 kDa chaperonin/0.448
1qrpHH0Pepsin A-43.4.23.10.447
2b53D23Cyclin-dependent kinase 22.7.11.220.447
2egbSAHDiphthine synthase/0.447
2eldSAHDiphthine synthase/0.447
2zb3NDPProstaglandin reductase 21.3.1.480.447
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3hmm855TGF-beta receptor type-12.7.11.300.447
3syiFADSulfide-quinone reductase/0.447
4dfrMTXDihydrofolate reductase1.5.1.30.447
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1nzdUPGDNA beta-glucosyltransferase/0.446
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
3l63CAMCamphor 5-monooxygenase1.14.15.10.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4a6nFADTetX family tetracycline inactivation enzyme/0.446
4a81DXCMajor pollen allergen Bet v 1-A/0.446
4b4w9L9Bifunctional protein FolD/0.446
4cd2FOLDihydrofolate reductase1.5.1.30.446
4ceaZSWIntegrase/0.446
1gcoNADGlucose 1-dehydrogenase1.1.1.470.445
1k6pXN3Gag-Pol polyprotein3.4.23.160.445
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.445
2e17SAHDiphthine synthase/0.445
2ejzSAHDiphthine synthase/0.445
2j7pGNPSignal recognition particle protein/0.445
2j7pGNPSignal recognition particle receptor FtsY/0.445
2oapANPType II secretion system protein (GspE-2)/0.445
2w6oOA3Biotin carboxylase6.3.4.140.445
2w6zL21Biotin carboxylase6.3.4.140.445
2zxuDSTtRNA dimethylallyltransferase2.5.1.750.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3w32W32Epidermal growth factor receptor2.7.10.10.445
4eji0QACytochrome P450 2A131.14.14.10.445
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.445
4id71G0Activated CDC42 kinase 1/0.445
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.445
4lxhC1EAlpha/beta hydrolase fold/0.445
4o4eATPKinase/0.445
4q71FADBifunctional protein PutA/0.445
4zohFADPutative oxidoreductase FAD-binding subunit/0.445
5cwa0GAAnthranilate synthase component 14.1.3.270.445
1e82M90Endothiapepsin3.4.23.220.444
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1fwmCB3Thymidylate synthase/0.444
2x9dITCTetracycline repressor protein class D/0.444
3d84NDPDihydrofolate reductase1.5.1.30.444
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3ocgOCGMitogen-activated protein kinase 14/0.444
3r5zF42Uncharacterized protein/0.444
3tqhNDPQuinone oxidoreductase/0.444
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fod0UVALK tyrosine kinase receptor2.7.10.10.444
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.444
4n9iPCGCatabolite expression activator/0.444
4r8hSP1cAMP-activated global transcriptional regulator CRP/0.444
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.444
5bt42LOBromodomain-containing protein 4/0.444
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.443
2i51FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding/0.443
3bpzCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.443
3fklFKLMitogen-activated protein kinase 14/0.443
3mtfA3FActivin receptor type-12.7.11.300.443
3slkNDPPolyketide synthase extender module 2/0.443
3t3r9PLCytochrome P450 2A61.14.130.443
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.443
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
4l9i8PRRhodopsin kinase/0.443
4lfiGNPCasein kinase II subunit alpha2.7.11.10.443
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.442
1q3ePCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.442
1sezOMNProtoporphyrinogen oxidase, mitochondrial1.3.3.40.442
1t85CAMCamphor 5-monooxygenase1.14.15.10.442
1vjy460TGF-beta receptor type-12.7.11.300.442
1xelUPGUDP-glucose 4-epimerase5.1.3.20.442
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3cgfJNFMitogen-activated protein kinase 102.7.11.240.442
3fwfCAMCamphor 5-monooxygenase1.14.15.10.442
3kytHC2Nuclear receptor ROR-gamma/0.442
3r34COA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.442
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
1jolFFODihydrofolate reductase1.5.1.30.441
1ppjANYCytochrome b/0.441
2a94AP0L-lactate dehydrogenase1.1.1.270.441
2ptmCMPHyperpolarization-activated (Ih) channel/0.441
2q61SF1Peroxisome proliferator-activated receptor gamma/0.441
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3d4pNADL-lactate dehydrogenase 11.1.1.270.441
3pgiF41Endothiapepsin3.4.23.220.441
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.441
1b8vNADMalate dehydrogenase/0.440
1k7l544Peroxisome proliferator-activated receptor alpha/0.440
1ykdCMPAdenylate cyclase/0.440
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2ejvNADL-threonine 3-dehydrogenase/0.440
2emrSAHDiphthine synthase/0.440
2p5uNADUDP-glucose 4-epimerase/0.440
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.440
3a7jADPSerine/threonine-protein kinase 242.7.11.10.440
3adaNADSubunit alpha of sarocosine oxidase/0.440
3el9DR7Gag-Pol polyprotein3.4.23.160.440
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4a9mP9MBromodomain-containing protein 2/0.440
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440
4y4jLNREndothiapepsin3.4.23.220.440
4y95746Tyrosine-protein kinase/0.440