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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jibTPPOxalyl-CoA decarboxylase4.1.1.8

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2jibTPPOxalyl-CoA decarboxylase4.1.1.81.000
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.513
2ji6TPWOxalyl-CoA decarboxylase4.1.1.80.506
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.500
1drhNAPDihydrofolate reductase1.5.1.30.498
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.496
1qpbTPPPyruvate decarboxylase isozyme 1/0.494
3o26NDPSalutaridine reductase/0.490
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.490
3rdqDTBStreptavidin/0.489
2ofv242Tyrosine-protein kinase Lck2.7.10.20.487
4e2bFMNDehydrogenase/0.486
2ihvTPPN(2)-(2-carboxyethyl)arginine synthase/0.484
2ym1FADPhenylacetone monooxygenase1.14.13.920.484
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.484
2c29NAPDihydroflavonol 4-reductase/0.483
2v3wTPPBenzoylformate decarboxylase4.1.1.70.483
3e92G6AMitogen-activated protein kinase 14/0.483
1uyhPU0Heat shock protein HSP 90-alpha/0.482
1wxjIPLTryptophan synthase alpha chain/0.482
1zgv501Prothrombin3.4.21.50.482
2bxqIMNSerum albumin/0.482
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.482
1d3dBZTProthrombin3.4.21.50.481
4zp1TPPPyruvate decarboxylase4.1.1.10.481
1peoDCPRibonucleoside-diphosphate reductase 2 subunit alpha1.17.4.10.479
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.479
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.479
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.478
1v35NAIEnoyl-ACP reductase/0.477
2nniMTKCytochrome P450 2C8/0.477
2a94AP0L-lactate dehydrogenase1.1.1.270.476
2bunFADAppA protein/0.476
2r0pK2CPutative FAD-monooxygenase/0.476
2r8oT5XTransketolase 1/0.476
2ogyC2F5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase2.1.1.2580.475
2xuzEB4Iron-uptake system-binding protein/0.475
4an4DUDPutative glycosyl transferase/0.475
3r5yF42Uncharacterized protein/0.474
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.473
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.473
4hy6FJ1Heat shock protein HSP 90-alpha/0.473
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.473
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.473
1ie3NADMalate dehydrogenase/0.472
1qm5PLPMaltodextrin phosphorylase2.4.1.10.472
2briANPUridylate kinase2.7.4.220.472
2ihuTP9N(2)-(2-carboxyethyl)arginine synthase/0.472
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.472
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.470
1osvCHCBile acid receptor/0.470
1uycPU7Heat shock protein HSP 90-alpha/0.470
2c42TPPPyruvate synthase/0.470
2xvv9DNSerum albumin/0.470
3uqdADPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.470
1dljUGAUDP-glucose 6-dehydrogenase/0.469
1o2g696Prothrombin3.4.21.50.469
1tu3GNPRas-related protein Rab-5A/0.469
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.469
3f03FMNPentaerythritol tetranitrate reductase/0.469
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.468
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.468
3gwdNAPCyclohexanone monooxygenase/0.468
4dpy2P0Mevalonate diphosphate decarboxylase/0.468
4qaiFMNNADPH dehydrogenase/0.468
1ht2ADPATP-dependent protease ATPase subunit HslU/0.467
1t4v14AProthrombin3.4.21.50.467
2h55DZ8Heat shock protein HSP 90-alpha/0.467
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.467
3fp0FP015-O-acetyltransferase/0.467
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.467
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.467
4df2FMNNADPH dehydrogenase/0.467
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.467
1bcuPRLProthrombin3.4.21.50.466
1pr9NAPL-xylulose reductase1.1.1.100.466
1qf4RPDAdenylosuccinate synthetase/0.466
2bufADPAcetylglutamate kinase/0.466
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.466
2r8pT6FTransketolase 1/0.466
2yk2YJXHeat shock protein HSP 90-alpha/0.466
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
4dpuAGSMevalonate diphosphate decarboxylase/0.466
1lquNDPNADPH-ferredoxin reductase FprA1.18.1.20.465
2fj1CTCTetracycline repressor protein class D/0.465
2g8yNADHydroxycarboxylate dehydrogenase B/0.465
2vmyFFOSerine hydroxymethyltransferase/0.465
2yk2YJWHeat shock protein HSP 90-alpha/0.465
3nmpPYVAbscisic acid receptor PYL2/0.465
1g4tFTPThiamine-phosphate synthase/0.464
2wzmNA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346/0.464
2ykeYKEHeat shock protein HSP 90-alpha/0.464
3f8kCOAUncharacterized protein/0.464
3t94MTAS-methyl-5'-thioadenosine phosphorylase/0.464
4cukNAID-lactate dehydrogenase/0.464
4xq9NADHomospermidine synthase2.5.1.440.464
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.463
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.463
2ag0TPPBenzaldehyde lyase/0.463
2d0oADPDiol dehydratase-reactivating factor alpha subunit/0.463
2zf051UProthrombin3.4.21.50.463
3nk7SAM23S rRNA (adenosine(1067)-2'-O)-methyltransferase/0.463
3w0hW12Vitamin D3 receptor/0.463
1ay0TPPTransketolase 12.2.1.10.462
1h74ADPHomoserine kinase2.7.1.390.462
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.462
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.462
4n3l2FNProthrombin3.4.21.50.462
1c1uBAIProthrombin3.4.21.50.461
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.461
1ipeNDPTropinone reductase 21.1.1.2360.461
1tl7FOKAdenylate cyclase type 2/0.461
1tl7FOKAdenylate cyclase type 5/0.461
1upw444Oxysterols receptor LXR-beta/0.461
1ypmRA4Prothrombin3.4.21.50.461
2ag1TPPBenzaldehyde lyase/0.461
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.461
2q5oTPWIndole-3-pyruvate decarboxylase4.1.1.740.461
2y6fM9FIsopenicillin N synthase1.21.3.10.461
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.461
4iva1J5Tyrosine-protein kinase JAK2/0.461
4pb25UDNucleoside permease/0.461
1bwlFMNNADPH dehydrogenase 11.6.99.10.460
1mvsDTMDihydrofolate reductase1.5.1.30.460
1mvtDTMDihydrofolate reductase1.5.1.30.460
1p0pBCHCholinesterase3.1.1.80.460
2e20B4PPropionate kinase/0.460
2e4nSAHDiphthine synthase/0.460
3ac1KZITyrosine-protein kinase Lck2.7.10.20.460
3bx5304Mitogen-activated protein kinase 14/0.460
3d7zGK5Mitogen-activated protein kinase 14/0.460
4dxaGSPRas-related protein Rap-1b/0.460
4twnB96Ephrin type-A receptor 32.7.10.10.460
4xymCOAAcyl-CoA synthetase (NDP forming)/0.460
5fsyAR6Uncharacterized protein/0.460
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2c3p1TPPyruvate synthase/0.459
2cvxDGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.459
2pmdGNPTranslation initiation factor 2 subunit gamma/0.459
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.459
2v3hI25Prothrombin3.4.21.50.459
2zb3NDPProstaglandin reductase 21.3.1.480.459
1c1wBAHProthrombin3.4.21.50.458
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.458
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.458
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.458
1iy8NADLevodione reductase/0.458
1kzjCB3Thymidylate synthase/0.458
1nzdUPGDNA beta-glucosyltransferase/0.458
1tysTMPThymidylate synthase/0.458
2b7aIZATyrosine-protein kinase JAK2/0.458
2x0rNADMalate dehydrogenase/0.458
3c27DKKProthrombin3.4.21.50.458
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.458
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.458
3i2834NBifunctional epoxide hydrolase 23.3.2.100.458
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.458
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.458
4mcd22LtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.458
4xqcNADHomospermidine synthase2.5.1.440.458
1drfFOLDihydrofolate reductase1.5.1.30.457
1m78NDPDihydrofolate reductase1.5.1.30.457
1q4t4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.457
2xvw9NRSerum albumin/0.457
3aosJH2Hemolymph juvenile hormone binding protein/0.457
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3maaFKPAdenylate cyclase type 2/0.457
3maaFKPAdenylate cyclase type 5/0.457
3w9rA8SAbscisic acid receptor PYL9/0.457
4qi5FADCellobiose dehydrogenase/0.457
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.457
8catNDPCatalase1.11.1.60.457
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.456
1u33LM2Pancreatic alpha-amylase/0.456
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.456
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.456
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.456
2zfq45UProthrombin3.4.21.50.456
3oibFDAPutative acyl-CoA dehydrogenase/0.456
4bakM67Prothrombin3.4.21.50.456
4du82P0Mevalonate diphosphate decarboxylase/0.456
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.456
4eji0QACytochrome P450 2A131.14.14.10.456
4u0oMTALipoyl synthase 2/0.456
4yqfGDPSeptin-9/0.456
5lc1NADL-threonine 3-dehydrogenase/0.456
1culFOKAdenylate cyclase type 2/0.455
1culFOKAdenylate cyclase type 5/0.455
1gc5ADPADP-dependent glucokinase2.7.1.1470.455
1gjrNAPFerredoxin--NADP reductase1.18.1.20.455
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.455
1w2xRCPAcetyl-CoA carboxylase/0.455
1wdtGTPElongation factor G (EF-G-2)/0.455
2aviBTNAvidin/0.455
2oz6CMPCyclic AMP receptor-like protein/0.455
2rc4ACOHistone acetyltransferase KAT6A/0.455
2v3oI26Prothrombin3.4.21.50.455
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.455
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.455
3c14FOKAdenylate cyclase type 2/0.455
3c14FOKAdenylate cyclase type 5/0.455
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.455
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.455
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.455
4fidGDPG protein alpha subunit, putative/0.455
5dmhADP3-oxo-tetronate kinase/0.455
1ao05GPAmidophosphoribosyltransferase/0.454
1fwkADPHomoserine kinase2.7.1.390.454
1h63FMNPentaerythritol tetranitrate reductase/0.454
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.454
1lb9DNQGlutamate receptor 2/0.454
1n5dNDPCarbonyl reductase [NADPH] 1/0.454
1qf5RPLAdenylosuccinate synthetase/0.454
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.454
1svmATPLarge T antigen3.6.40.454
2amb17HAndrogen receptor/0.454
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.454
2nyaMGDPeriplasmic nitrate reductase1.7.99.40.454
2tpsTPSThiamine-phosphate synthase/0.454
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.454
3hpqAP5Adenylate kinase/0.454
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3nglNAPBifunctional protein FolD/0.454
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.454
4m6jNDPDihydrofolate reductase1.5.1.30.454
4yaiNAIC alpha-dehydrogenase/0.454
5i2hAGIO-methyltransferase family 2/0.454
1c1dNAIPhenylalanine dehydrogenase/0.453
1cf3FADGlucose oxidase1.1.3.40.453
1cs4FOKAdenylate cyclase type 2/0.453
1cs4FOKAdenylate cyclase type 5/0.453
1e1mNAPNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.453
1gj5130Prothrombin3.4.21.50.453
1gpuTHDTransketolase 12.2.1.10.453
1qvnFRIInterleukin-2/0.453
1ryiFADGlycine oxidase1.4.3.190.453
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.453
2balPQAMitogen-activated protein kinase 14/0.453
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.453
2wipP49Cyclin-dependent kinase 22.7.11.220.453
2xa4AZ5Tyrosine-protein kinase JAK2/0.453
3cbgSAHO-methyltransferase/0.453
3cgdCOACoenzyme A disulfide reductase/0.453
3d8xFADThioredoxin reductase 11.8.1.90.453
3o0qADNVitamin B12-dependent ribonucleotide reductase/0.453
3qwbNDPProbable quinone oxidoreductase1.6.5.50.453
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4a2aATPCell division protein FtsA/0.453
4baoMVFProthrombin3.4.21.50.453
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.453
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.453
4u8iFDAUDP-galactopyranose mutase/0.453
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.453
5c88COAN-alpha-acetyltransferase/0.453
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.452
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.452
1e1lNAPNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.452
1kvkATPMevalonate kinase2.7.1.360.452
1tkcM6TTransketolase 12.2.1.10.452
1z71L17Prothrombin3.4.21.50.452
2gr0FADFerredoxin reductase/0.452
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.452
2r2mI50Prothrombin3.4.21.50.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.452
3h3qH13Collagen type IV alpha-3-binding protein/0.452
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.452
4d03FADPhenylacetone monooxygenase1.14.13.920.452
4eh8IRGMitogen-activated protein kinase 14/0.452
4pd6URINucleoside permease/0.452
4pleCPSNuclear receptor subfamily 5 group A member 2/0.452
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.452
4udrFAD5-(hydroxymethyl)furfural oxidase/0.452
1mjbACOHistone acetyltransferase ESA1/0.451
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.451
1nzq162Prothrombin3.4.21.50.451
1xjnDTPVitamin B12-dependent ribonucleotide reductase/0.451
1y4sADPChaperone protein HtpG/0.451
1z7yAA5Cysteine synthase 12.5.1.470.451
2bpoNAPNADPH--cytochrome P450 reductase/0.451
2izhBTNStreptavidin/0.451
2r5nTPPTransketolase 1/0.451
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.451
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.451
3hk1B64Fatty acid-binding protein, adipocyte/0.451
3rsrN5PRibonucleoside-diphosphate reductase large chain 11.17.4.10.451
3s87DGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.451
4c62XWWTyrosine-protein kinase JAK2/0.451
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.451
4j491J1Uncharacterized protein/0.451
4rujVDXVitamin D3 receptor A/0.451
4y35F90Endothiapepsin3.4.23.220.451
4z875GPInosine-5'-monophosphate dehydrogenase/0.451
5c3zACPRibokinase/0.451
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.451
1e2jTHMThymidine kinase/0.450
1hvyD16Thymidylate synthase2.1.1.450.450
1ivhCOSIsovaleryl-CoA dehydrogenase, mitochondrial1.3.8.40.450
1nhtPGSAdenylosuccinate synthetase/0.450
2gvdFKPAdenylate cyclase type 2/0.450
2gvdFKPAdenylate cyclase type 5/0.450
2rm2W43Genome polyprotein/0.450
2vbpVB1Isopenicillin N synthase1.21.3.10.450
2yjxYJXHeat shock protein HSP 90-alpha/0.450
2ylzFADPhenylacetone monooxygenase1.14.13.920.450
3a0tADPSensor histidine kinase/0.450
3a6qFMNFMN-binding protein/0.450
3iaeD7KBenzaldehyde lyase/0.450
3ibqATPPyridoxal kinase/0.450
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3p0hFSEPutative tyrosyl-tRNA synthetase/0.450
3to6LYS_CMCHistone acetyltransferase ESA1/0.450
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.450
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.450
4xrgNADHomospermidine synthase2.5.1.440.450
1e2nRCAThymidine kinase/0.449
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.449
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1meiXMPInosine-5'-monophosphate dehydrogenase/0.449
1ozhHE3Acetolactate synthase, catabolic2.2.1.60.449
1x0pFADTll0078 protein/0.449
1zd9GDPADP-ribosylation factor-like protein 8A/0.449
2aznNAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase/0.449
2dwbANPAurora kinase A2.7.11.10.449
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.449
2gyoCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.449
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.449
2q5oPPYIndole-3-pyruvate decarboxylase4.1.1.740.449
2rtfBTNStreptavidin/0.449
2zrjAGSProtein RecA/0.449
3cntFADPolyamine oxidase FMS1/0.449
3dufR1TPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.449
3dufR1TPyruvate dehydrogenase E1 component subunit beta1.2.4.10.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3k7mFAD6-hydroxy-L-nicotine oxidase/0.449
3mjeNDPAmphB/0.449
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.449
3w0c6DSVitamin D3 receptor/0.449
4c03SFGProtein arginine N-methyltransferase 6/0.449
4db1ANPMyosin-7/0.449
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.449
4i01CMPcAMP-activated global transcriptional regulator CRP/0.449
4j7uNAPSepiapterin reductase1.1.1.1530.449
4kweGDPCell division protein FtsZ/0.449
4xj43ATCyclic GMP-AMP synthase/0.449
4y3qF02Endothiapepsin3.4.23.220.449
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.449
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.449
1afeALZProthrombin3.4.21.50.448
1dz6CAMCamphor 5-monooxygenase1.14.15.10.448
1jwtBLIProthrombin3.4.21.50.448
1mg5NAIAlcohol dehydrogenase1.1.1.10.448
1rx8FOLDihydrofolate reductase1.5.1.30.448
1uyiPUZHeat shock protein HSP 90-alpha/0.448
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.448
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
2rc6NAPFerredoxin--NADP reductase/0.448
2rkiTT1Gag-Pol polyprotein2.7.7.490.448
2zcvNDPQuinone oxidoreductase 21.6.5.20.448
3dmeFADPutative conserved exported protein/0.448
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.448
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.448
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.448
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.448
3w0aDS5Vitamin D3 receptor/0.448
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.448
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.448
4gk3L87Ephrin type-A receptor 32.7.10.10.448
4ienCOAPutative acyl-CoA hydrolase/0.448
4ly91YYGlucokinase regulatory protein/0.448
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1mueCDDProthrombin3.4.21.50.447
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.447
2bjhFERFeruloyl esterase A3.1.1.730.447
2bxtC2DProthrombin3.4.21.50.447
2dv3SAHDiphthine synthase/0.447
2itpAEEEpidermal growth factor receptor2.7.10.10.447
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.447
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.447
2vqbNAPPutative flavin-containing monooxygenase/0.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
2xgs44PUncharacterized protein/0.447
3b2eADPATPase GET3/0.447
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.447
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3h3sH15Collagen type IV alpha-3-binding protein/0.447
3junAJDPhenazine biosynthesis protein A/B/0.447
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.447
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
3qtv06PProthrombin3.4.21.50.447
3sdkP3NProteasome subunit beta type-53.4.25.10.447
3sdkP3NProteasome subunit beta type-63.4.25.10.447
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.447
4c6uTLG3-oxoacyl-ACP synthase/0.447
4d9eLCSD-cysteine desulfhydrase/0.447
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.447
4lj9ACPChaperone protein ClpB/0.447
4rupH97Vitamin D3 receptor A/0.447
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.447
4xnw2IDP2Y purinoceptor 1/0.447
1ofhADPATP-dependent protease ATPase subunit HslU/0.446
1qy5NECEndoplasmin/0.446
1u9iATPCircadian clock protein kinase KaiC2.7.11.10.446
1vgrCOAFormyl-CoA:oxalate CoA-transferase/0.446
2bdyUNBProthrombin3.4.21.50.446
2bxmIMNSerum albumin/0.446
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.446
2hveADPNucleoside diphosphate kinase A2.7.4.60.446
2izfBTNStreptavidin/0.446
2xlsFADPutative flavin-containing monooxygenase/0.446
3b8z294A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.446
3c15FOKAdenylate cyclase type 2/0.446
3c15FOKAdenylate cyclase type 5/0.446
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3ekrPY9Heat shock protein HSP 90-alpha/0.446
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3lsiFADPyranose 2-oxidase/0.446
3r96ACOMccE protein/0.446
3tvqDQHMultifunctional cyclase-dehydratase-3-O-methyl transferase TcmN2.1.10.446
4kgnSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.446
4qbiAP5Adenylate kinase/0.446
4xybNDPFormate dehydrogenase/0.446
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.446
1ix1BB2Peptide deformylase/0.445
1knrFADL-aspartate oxidase1.4.3.160.445
1pjkANPCasein kinase II subunit alpha2.7.11.10.445
1qaxHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.445
1s1vTNKGag-Pol polyprotein2.7.7.490.445
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1tf7ATPCircadian clock protein kinase KaiC2.7.11.10.445
1uy9PU6Heat shock protein HSP 90-alpha/0.445
2a1nCAMCamphor 5-monooxygenase1.14.15.10.445
2acxANPG protein-coupled receptor kinase 62.7.11.160.445
2akoADPGlutamate 5-kinase/0.445
2b8jADNClass B acid phosphatase3.1.3.20.445
2fhlBNIAvidin-related protein 4/5/0.445
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.445
2o7pNAPRiboflavin biosynthesis protein RibD/0.445
2ociTYCValacyclovir hydrolase3.10.445
2oegUPGUDP-glucose pyrophosphorylase/0.445
2xpuTDCTetracycline repressor protein class D/0.445
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.445
3biz61EWee1-like protein kinase2.7.10.20.445
3cbsR12Cellular retinoic acid-binding protein 2/0.445
3clsFADElectron transfer flavoprotein subunit alpha/0.445
3edjBCDCyclomaltodextrinase/0.445
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3gy0NAPNAD(P)-dependent oxidoreductase/0.445
3k8tDGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.445
3mvm39PMitogen-activated protein kinase 14/0.445
3r7cFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.445
3vt7VDXVitamin D3 receptor/0.445
3zvuA8SAbscisic acid receptor PYR1/0.445
4b8zGDPGDP-L-fucose synthase1.1.1.2710.445
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.445
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.445
4ke11R6Beta-secretase 13.4.23.460.445
4looSB4Mitogen-activated protein kinase 14/0.445
4m5pFMNNADPH dehydrogenase/0.445
4m6l21VDihydrofolate reductase1.5.1.30.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
1ia1NDPDihydrofolate reductase1.5.1.30.444
1opbRETRetinol-binding protein 2/0.444
1qrpHH0Pepsin A-43.4.23.10.444
1qy8RDIEndoplasmin/0.444
1rkhVD2Vitamin D3 receptor/0.444
1u4oNDDL-lactate dehydrogenase1.1.1.270.444
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.444
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.444
2c3yHTLPyruvate synthase/0.444
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.444
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.444
2e8hSAHDiphthine synthase/0.444
2hcdBIVVitamin D3 receptor A/0.444
2v1aFMNNPH1-1/0.444
2vkeTACTetracycline repressor protein class D/0.444
2ydvNECAdenosine receptor A2a/0.444
3a6rFMNFMN-binding protein/0.444
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.444
3dvlATPCircadian clock protein kinase KaiC2.7.11.10.444
3lpkZ76Beta-secretase 13.4.23.460.444
3mauPLRPutative sphingosine-1-phosphate lyase/0.444
3mpt1GKMitogen-activated protein kinase 14/0.444
3qgi33FGenome polyprotein2.7.7.480.444
3vtdTKDVitamin D3 receptor/0.444
3zmmF9JTyrosine-protein kinase JAK2/0.444
4fncHMUG/T mismatch-specific thymine DNA glycosylase3.2.2.290.444
4g1y0VOVitamin D3 receptor A/0.444
4g2h0VQVitamin D3 receptor A/0.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.444
4ntcFADThioredoxin reductase gliT/0.444
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.444
5c4iTPPOxalate oxidoreductase subunit alpha/0.444
5c4iTPPOxalate oxidoreductase subunit beta/0.444
5cmx0G6Prothrombin3.4.21.50.444
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.444
4ea30NNNociceptin receptor/0.444
1f5nGNPGuanylate-binding protein 1/0.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1gleADPGlycerol kinase/0.443
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.443
1nm6L86Prothrombin3.4.21.50.443
1sdmADPKinesin heavy chain-like protein/0.443
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.443
2c12FADNitroalkane oxidase1.7.3.10.443
2c5eGDDGDP-mannose 3,5-epimerase5.1.3.180.443
2gzwCMPcAMP-activated global transcriptional regulator CRP/0.443
2pg0FADAcyl-CoA dehydrogenase/0.443
2po7CHDFerrochelatase, mitochondrial4.99.1.10.443
2rtrIMIStreptavidin/0.443
2zlaVDBVitamin D3 receptor/0.443
3ekuCY9Actin-5C/0.443
3kpzZNEVitamin D3 receptor/0.443
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.443
3q0uLL3HTH-type transcriptional regulator EthR/0.443
3rdiCMPcAMP-activated global transcriptional regulator CRP/0.443
3s8aDGTRibonucleoside-diphosphate reductase large chain 11.17.4.10.443
3sp9IL2Peroxisome proliferator-activated receptor delta/0.443
3u8m09RAcetylcholine-binding protein/0.443
3up0D7SaceDAF-12/0.443
3w0yDS4Vitamin D3 receptor/0.443
3wtkTH4Acetylcholine-binding protein/0.443
4b45GSPTubulin-like protein CetZ2/0.443
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4dh60KNBeta-secretase 13.4.23.460.443
4dqwATPInosine-5'-monophosphate dehydrogenase/0.443
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.443
4k9pTPPBenzoylformate decarboxylase4.1.1.70.443
4kin1M8Mitogen-activated protein kinase 14/0.443
4l4fCAMCamphor 5-monooxygenase1.14.15.10.443
4l8u9AZSerum albumin/0.443
4oaqNDPR-specific carbonyl reductase/0.443
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
5c3yAN2Ribokinase/0.443
1b8vNADMalate dehydrogenase/0.442
1bmdNADMalate dehydrogenase/0.442
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.442
1ie8KH1Vitamin D3 receptor/0.442
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.442
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.442
1trgCB3Thymidylate synthase/0.442
1vzqSHYProthrombin3.4.21.50.442
2c3oTPPPyruvate synthase/0.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.442
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.442
2hc4VDXVitamin D3 receptor A/0.442
2iluNDPLactaldehyde dehydrogenase1.2.1.220.442
2jl1NAPTriphenylmethane reductase/0.442
2p5uNADUDP-glucose 4-epimerase/0.442
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.442
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.442
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.442
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.442
2xlpFADPutative flavin-containing monooxygenase/0.442
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.442
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.442
2zlcVDXVitamin D3 receptor/0.442
3a783EVVitamin D3 receptor/0.442
3ac2KSETyrosine-protein kinase Lck2.7.10.20.442
3bv3P39Mitogen-activated protein kinase 14/0.442
3elm24FCollagenase 33.4.240.442
3fln3FNMitogen-activated protein kinase 14/0.442
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.442
3p1799PProthrombin3.4.21.50.442
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.442
4el5D1MGlycogen phosphorylase, muscle form2.4.1.10.442
4hfp15UProthrombin3.4.21.50.442
4jxrACOAcetyltransferase/0.442
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.442
4p0gBLGMembrane-bound lytic murein transglycosylase F/0.442
4u0mATPCyclic GMP-AMP synthase/0.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5envNADAlcohol dehydrogenase 11.1.1.10.442
4mqt2CUMuscarinic acetylcholine receptor M2/0.442
1dgmADNAdenosine kinase2.7.1.200.441
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1f0xFADD-lactate dehydrogenase1.1.1.280.441
1k22MELProthrombin3.4.21.50.441
1kekHTLPyruvate synthase/0.441
1levCLIFructose-1,6-bisphosphatase 13.1.3.110.441
1m17AQ4Epidermal growth factor receptor2.7.10.10.441
1svwGTPProbable GTP-binding protein EngB/0.441
2b3dFADModulator of drug activity B/0.441
2ftoTMPThymidylate synthase/0.441
2gtnLIEMitogen-activated protein kinase 14/0.441
2huvSAHDiphthine synthase/0.441
2jirMGDPeriplasmic nitrate reductase/0.441
2op18PCEnoyl-ACP reductase/0.441
2panTDPGlyoxylate carboligase4.1.1.470.441
3bv2P38Mitogen-activated protein kinase 14/0.441
3cosNADAlcohol dehydrogenase 41.1.1.10.441
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.441
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.441
3eq02TSProthrombin3.4.21.50.441
3gqoAPRNon-structural polyprotein/0.441
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.441
3hz5Z64Heat shock protein HSP 90-alpha/0.441
3owj1ELCasein kinase II subunit alpha2.7.11.10.441
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.441
3utu1TSProthrombin3.4.21.50.441
4banM6SProthrombin3.4.21.50.441
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.441
4fhd0TTSpore photoproduct lyase/0.441
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.441
4g0nGNPGTPase HRas/0.441
4gh5NADShort-chain dehydrogenase/reductase SDR/0.441
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.441
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.441
4qxr1YEStimulator of interferon genes protein/0.441
4r1lADPPhenylacetate-coenzyme A ligase/0.441
4z9rFMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.441
5idwNAPShort-chain dehydrogenase/reductase SDR/0.441
1blzACVIsopenicillin N synthase1.21.3.10.440
1c4uIH1Prothrombin3.4.21.50.440
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1e94ANPATP-dependent protease ATPase subunit HslU/0.440
1eqbFFOSerine hydroxymethyltransferase2.1.2.10.440
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.440
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.440
1gotGDPGuanine nucleotide-binding protein G(t) subunit alpha-1/0.440
1im2ADPATP-dependent protease ATPase subunit HslU/0.440
1k21IGNProthrombin3.4.21.50.440
1pzhNADLactate dehydrogenase/0.440
1uamSAHtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.440
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.440
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.440
2pciSAHDiphthine synthase/0.440
2qblCAMCamphor 5-monooxygenase1.14.15.10.440
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.440
2vd5BI8Myotonin-protein kinase2.7.11.10.440
2vk8TPPPyruvate decarboxylase isozyme 1/0.440
2w93TPPPyruvate decarboxylase isozyme 1/0.440
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.440
2zg050UProthrombin3.4.21.50.440
3d8bADPFidgetin-like protein 13.6.40.440
3golXNDGenome polyprotein2.7.7.480.440
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.440
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.440
3pqfNADL-lactate dehydrogenase1.1.1.270.440
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.440
3rvg17PTyrosine-protein kinase JAK2/0.440
3sheI85MAP kinase-activated protein kinase 32.7.11.10.440
4b8zNAPGDP-L-fucose synthase1.1.1.2710.440
4baqM4ZProthrombin3.4.21.50.440
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.440
4i02CMPcAMP-activated global transcriptional regulator CRP/0.440
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.440
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.440
4jq3NAPAldo-keto reductase family 1 member C2/0.440
4l4eCAMCamphor 5-monooxygenase1.14.15.10.440
4mgkCMPRap guanine nucleotide exchange factor 4/0.440
4oztP1AEcdysone receptor, putative/0.440