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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2izsBRQCasein kinase I isoform gamma-32.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2izsBRQCasein kinase I isoform gamma-32.7.11.11.000
4hgs15GCasein kinase I isoform gamma-32.7.11.10.714
2izrBRKCasein kinase I isoform gamma-32.7.11.10.623
4g170VNCasein kinase I isoform gamma-32.7.11.10.486
4g160VMCasein kinase I isoform gamma-32.7.11.10.474
3lltANPProtein serine/threonine kinase-1/0.460
4ic7ANPMitogen-activated protein kinase 72.7.11.240.460
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.457
3c4xATPRhodopsin kinase/0.457
4ysjADPCalmodulin-like domain protein kinase/0.456
3t8oATPRhodopsin kinase/0.454
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.454
4bcmT7ZCyclin-dependent kinase 22.7.11.220.451
2c475IDCasein kinase I isoform gamma-2/0.449
2izuP01Casein kinase I isoform gamma-32.7.11.10.449
3c4zADPRhodopsin kinase/0.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
2izt23DCasein kinase I isoform gamma-32.7.11.10.447
4c4h7RODual specificity protein kinase TTK2.7.12.10.447
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.446
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3c4wATPRhodopsin kinase/0.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3my5RFZCyclin-dependent kinase 22.7.11.220.440