sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 1.000 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.709 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.695 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.679 | |
| 1ads | NAP | Aldose reductase | 1.1.1.21 | 0.674 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.660 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.632 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.631 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2acu | NAP | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.621 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2acq | NAP | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2iq0 | NAP | Aldose reductase | 1.1.1.21 | 0.601 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.591 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.590 | |
| 1ah4 | NAP | Aldose reductase | 1.1.1.21 | 0.589 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.587 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.580 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.576 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.571 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.566 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.565 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.559 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.557 | |
| 2acs | NAP | Aldose reductase | 1.1.1.21 | 0.556 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.554 | |
| 3v36 | NAP | Aldose reductase | 1.1.1.21 | 0.550 | |
| 1x96 | NAP | Aldose reductase | 1.1.1.21 | 0.545 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.539 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.534 | |
| 1x98 | NAP | Aldose reductase | 1.1.1.21 | 0.533 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.529 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.519 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.517 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.516 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.514 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.508 | |
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.507 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.506 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.505 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.502 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.497 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.495 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.494 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.493 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.492 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.491 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.490 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.490 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.490 | |
| 1u08 | PLP | Methionine aminotransferase | / | 0.488 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.486 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.486 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.486 | |
| 3h7u | NAP | NADPH-dependent aldo-keto reductase, chloroplastic | / | 0.485 | |
| 2pev | NDP | Aldose reductase | 1.1.1.21 | 0.484 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.484 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.484 | |
| 4mrx | CZH | Obelin | / | 0.484 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.483 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.483 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.482 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.481 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.481 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.480 | |
| 2hzq | STR | Apolipoprotein D | / | 0.480 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.479 | |
| 1rxj | BNI | Streptavidin | / | 0.478 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.478 | |
| 3c1o | NAP | Eugenol synthase | / | 0.478 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.477 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.477 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.477 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.477 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.477 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.475 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.475 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.475 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.474 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.474 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.473 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.473 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.472 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.471 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.471 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.470 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.469 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.467 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.466 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.466 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.465 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.465 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.464 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.464 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.464 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4j7h | TRH | PCZA361.3 | / | 0.464 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2po3 | T4K | 4-dehydrase | / | 0.463 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.462 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.462 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.462 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.462 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.462 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.462 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.461 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.461 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.460 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.459 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.459 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.458 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.458 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.458 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.458 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.457 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.457 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.456 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.456 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.456 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.456 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.455 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.455 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2qry | TPS | Thiamine-binding periplasmic protein | / | 0.455 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.454 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.454 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.453 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.453 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.453 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.453 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 1jf2 | CZH | Obelin | / | 0.452 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.452 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.451 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.451 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.451 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.451 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.451 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.451 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.450 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.450 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.450 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.449 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.449 | |
| 2h7j | H7J | Cathepsin S | 3.4.22.27 | 0.449 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.449 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.449 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.449 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.449 | |
| 3hth | PRL | EbrA repressor | / | 0.449 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.449 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.449 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.448 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.448 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.448 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.448 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.448 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.448 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4j7g | TRH | PCZA361.3 | / | 0.448 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1e2l | TMC | Thymidine kinase | / | 0.447 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.447 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.447 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.447 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.447 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.446 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.446 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.446 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.446 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.445 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.445 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.445 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.445 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.445 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.445 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.444 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1s36 | CEI | Obelin | / | 0.444 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.444 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2xvw | 9NR | Serum albumin | / | 0.444 | |
| 2zoz | ET | Transcriptional regulator | / | 0.444 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.444 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4jui | EGR | Tannase | / | 0.444 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.443 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.443 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3x03 | ANP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.443 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.443 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.442 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.442 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.442 | |
| 4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2c6c | 24I | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.441 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.441 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.441 | |
| 3up3 | XCA | aceDAF-12 | / | 0.441 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.441 | |
| 4xwt | U5P | Ribonuclease J | / | 0.441 | |
| 5agp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1qv0 | CZH | Obelin | / | 0.440 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3b9g | IMH | IAG-nucleoside hydrolase | / | 0.440 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.440 | |
| 3ojg | HL4 | Phosphotriesterase | / | 0.440 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.440 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.440 |