sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2ipw | 2CL | Aldose reductase | 1.1.1.21 | 1.000 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.636 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.593 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.581 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.555 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.551 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.551 | |
| 2nvd | ITB | Aldose reductase | 1.1.1.21 | 0.545 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.536 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.532 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.531 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.528 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.528 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.523 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.521 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.520 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.519 | |
| 1az2 | NAP | Aldose reductase | 1.1.1.21 | 0.517 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.516 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.514 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.513 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.513 | |
| 3h4g | FID | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.513 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.510 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.510 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.509 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.507 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.507 | |
| 1rxj | BNI | Streptavidin | / | 0.505 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.505 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.504 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.504 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.503 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.502 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.501 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.499 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.499 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.498 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.498 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.498 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.498 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.497 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.497 | |
| 3qkz | NAP | Aldose reductase-related protein 1 | 1.1.1.21 | 0.497 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.497 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.496 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.495 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.495 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.494 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.491 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.490 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.490 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.489 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.488 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.488 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.487 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.487 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.486 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.485 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.485 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.485 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.485 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.485 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.485 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.484 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.484 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.483 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.483 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.483 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.483 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.482 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.481 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.481 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.481 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.481 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.481 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.479 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.479 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.479 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.478 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.478 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.477 | |
| 3fx4 | FX4 | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.477 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.476 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.475 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.475 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.475 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.474 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.474 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.474 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.473 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.473 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.473 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.471 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.471 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.471 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.471 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.471 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.470 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.470 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.470 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.470 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 3cfo | GMP | DNA-directed DNA polymerase | / | 0.470 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.470 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.469 | |
| 1lke | DOG | Bilin-binding protein | / | 0.469 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.469 | |
| 3u8f | FGM | Ribosome inactivating protein | / | 0.469 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.469 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.468 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.468 | |
| 3c1o | NAP | Eugenol synthase | / | 0.467 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.466 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.465 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.464 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 4jtp | ASC | Ribosome inactivating protein | / | 0.464 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.464 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.464 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.463 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.462 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.462 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.461 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.461 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.461 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.461 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4j7h | TRH | PCZA361.3 | / | 0.461 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.460 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.460 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.460 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.460 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.460 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.458 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.458 | |
| 3lcc | SAH | Thiocyanate methyltransferase 1 | / | 0.458 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.458 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.457 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.457 | |
| 1u08 | PLP | Methionine aminotransferase | / | 0.457 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.457 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.457 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.457 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.457 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.457 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.457 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.457 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.457 | |
| 5jjr | SAH | Genome polyprotein | / | 0.457 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.456 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.456 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.456 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.456 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.456 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.456 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.455 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3qji | MGP | Ribosome inactivating protein | / | 0.455 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.455 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.455 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.454 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.454 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.453 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.453 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4bmp | FMN | Protein NrdI | / | 0.453 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4xcz | T3Q | Qdtf | / | 0.453 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.452 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3n3b | FMN | Protein NrdI | / | 0.452 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.452 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.452 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.452 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.452 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.451 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.451 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.451 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.450 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.450 | |
| 2hzq | STR | Apolipoprotein D | / | 0.450 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.450 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.450 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.449 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.449 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.449 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.449 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.449 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.449 | |
| 4emr | MGP | Ribosome inactivating protein | / | 0.449 | |
| 4g56 | SAH | Protein arginine N-methyltransferase 5 | / | 0.449 | |
| 4jhi | EMU | Nodulin-13 | / | 0.449 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.448 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.448 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.448 | |
| 1s07 | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.448 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2bu5 | TF1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.448 | |
| 3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.448 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.448 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4ixt | 1H1 | Halohydrin dehalogenase | / | 0.448 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.448 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.447 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qy2 | IPZ | Major urinary protein 1 | / | 0.447 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.447 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.447 | |
| 1s36 | CEI | Obelin | / | 0.447 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.447 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.447 | |
| 2zoz | ET | Transcriptional regulator | / | 0.447 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.447 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.447 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 1hlk | 113 | Metallo-beta-lactamase type 2 | / | 0.446 | |
| 1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.446 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.445 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.445 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.445 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.445 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.445 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.445 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.445 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.444 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 4j7g | TRH | PCZA361.3 | / | 0.444 | |
| 4kyk | IMN | Lactoylglutathione lyase | 4.4.1.5 | 0.444 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.444 | |
| 4lwx | MU2 | Ribosome inactivating protein | / | 0.444 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.444 | |
| 5epe | SAH | Uncharacterized protein | / | 0.444 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.444 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.443 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.443 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.443 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.443 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.443 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.443 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.442 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.442 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.442 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.442 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.442 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.442 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.442 | |
| 3dz2 | A8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.442 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.442 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4pu2 | PLU | Aminopeptidase N | / | 0.442 | |
| 1a8t | 061 | Metallo-beta-lactamase type 2 | / | 0.441 | |
| 1bh5 | GTX | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 1ddt | APU | Diphtheria toxin | / | 0.441 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.441 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.441 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3n39 | FMN | Protein NrdI | / | 0.441 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.441 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4hh4 | SAH | CcbJ | / | 0.441 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.440 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1t48 | BB3 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.440 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.440 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.440 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.440 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3htj | ET | EbrA repressor | / | 0.440 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 |