Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2io6330Wee1-like protein kinase2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2io6330Wee1-like protein kinase2.7.10.21.000
2z2w770Wee1-like protein kinase2.7.10.20.826
2in6839Wee1-like protein kinase2.7.10.20.764
3biz61EWee1-like protein kinase2.7.10.20.714
3cqeP91Wee1-like protein kinase2.7.10.20.679
1x8b824Wee1-like protein kinase2.7.10.20.650
3cr0809Wee1-like protein kinase2.7.10.20.639
3bi6396Wee1-like protein kinase2.7.10.20.604
2yac937Serine/threonine-protein kinase PLK12.7.11.210.543
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.521
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.519
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.518
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.504
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.503
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.503
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.500
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.499
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.495
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.494
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.491
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.487
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.484
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.484
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.484
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.479
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.479
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.478
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.478
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.477
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.475
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
2owb626Serine/threonine-protein kinase PLK12.7.11.210.474
4qnaX11Serine/threonine-protein kinase 242.7.11.10.473
3zewSTUEphrin type-B receptor 42.7.10.10.472
2yn8STUEphrin type-B receptor 42.7.10.10.468
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.467
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.466
3d5wADPSerine/threonine-protein kinase PLK/0.466
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.464
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.464
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.461
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.460
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.460
4hvh19RTyrosine-protein kinase JAK32.7.10.20.459
3zh8C58Protein kinase C iota type2.7.11.130.458
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.457
4bftZVTPantothenate kinase2.7.1.330.457
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.457
4wkqIREEpidermal growth factor receptor2.7.10.10.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.455
4e4m0NHTyrosine-protein kinase JAK2/0.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
2x9vTMQPteridine reductase/0.453
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.452
1yvj4STTyrosine-protein kinase JAK32.7.10.20.451
3zep1NXTyrosine-protein kinase JAK32.7.10.20.451
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4zasTYDCalS13/0.450
2yhuWHFPteridine reductase/0.449
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.449
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2itpAEEEpidermal growth factor receptor2.7.10.10.448
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.448
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
4bfwZVWPantothenate kinase2.7.1.330.447
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
4iarERM5-hydroxytryptamine receptor 1B/0.446
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.444
4fnyI3KALK tyrosine kinase receptor2.7.10.10.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.443
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2gjnFMNNitronate monooxygenase1.13.12.160.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
4bfvZVVPantothenate kinase2.7.1.330.442
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
4riyADPEpidermal growth factor receptor2.7.10.10.442
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.441
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
4grb0XGCasein kinase II subunit alpha2.7.11.10.441
3reyXACAdenosine receptor A2a/0.441
4jq7KJQEpidermal growth factor receptor2.7.10.10.440
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.440