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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2in6839Wee1-like protein kinase2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2in6839Wee1-like protein kinase2.7.10.21.000
2z2w770Wee1-like protein kinase2.7.10.20.741
1x8b824Wee1-like protein kinase2.7.10.20.708
2io6330Wee1-like protein kinase2.7.10.20.654
3bi6396Wee1-like protein kinase2.7.10.20.594
3cr0809Wee1-like protein kinase2.7.10.20.568
3cqeP91Wee1-like protein kinase2.7.10.20.557
3biz61EWee1-like protein kinase2.7.10.20.555
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.489
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.486
2yac937Serine/threonine-protein kinase PLK12.7.11.210.485
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.478
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.477
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.475
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.469
3zh8C58Protein kinase C iota type2.7.11.130.464
2owb626Serine/threonine-protein kinase PLK12.7.11.210.459
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.456
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.456
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.453
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.450
4qnaX11Serine/threonine-protein kinase 242.7.11.10.450
3zep1NXTyrosine-protein kinase JAK32.7.10.20.448
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
4gmy0X5Tyrosine-protein kinase JAK2/0.447
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.446
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.445
3at4CCKCasein kinase II subunit alpha2.7.11.10.445
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.445
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.441
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.441
1x1cSAHC-20 methyltransferase/0.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.440