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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ii3CAOLipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.168

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ii3CAOLipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.1681.000
2ii5CO6Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.1680.629
1umaIN2Prothrombin3.4.21.50.496
4lcjNADC-terminal-binding protein 2/0.496
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.495
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.493
1gj5130Prothrombin3.4.21.50.492
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.487
2v2zADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.487
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.487
4abkAR6Poly [ADP-ribose] polymerase 142.4.2.300.486
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
3iqgASN_TRP_ASN_ILECysteine synthase2.5.1.470.485
4e2dFMNDehydrogenase/0.485
1oklMNSCarbonic anhydrase 24.2.1.10.481
3a0tADPSensor histidine kinase/0.481
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.481
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.480
1xe65FPPlasmepsin-23.4.23.390.479
4a8v2ANMajor pollen allergen Bet v 1-J/0.479
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.479
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.479
1o2g696Prothrombin3.4.21.50.478
3nxxNDPDihydrofolate reductase1.5.1.30.478
3p62FMNPentaerythritol tetranitrate reductase/0.478
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.477
1mvtDTMDihydrofolate reductase1.5.1.30.476
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.476
1vi2NADQuinate/shikimate dehydrogenase/0.476
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.475
1nvtNAPShikimate dehydrogenase (NADP(+))/0.475
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.474
2ldbNADL-lactate dehydrogenase1.1.1.270.474
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.474
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.474
1dgmADNAdenosine kinase2.7.1.200.472
1nbmATPATP synthase subunit alpha, mitochondrial/0.472
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.472
2jgsBTNAvidin/0.472
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.472
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.472
1icsFMN12-oxophytodienoate reductase 11.3.1.420.471
1s3uTQDDihydrofolate reductase1.5.1.30.471
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.471
4kgkGTPUncharacterized protein/0.471
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.471
1nm6L86Prothrombin3.4.21.50.470
2rlcCHDCholoylglycine hydrolase3.5.1.240.470
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.469
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2w3bNDPDihydrofolate reductase1.5.1.30.469
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.469
3e8xNAPBH1520 protein/0.469
3h3qH13Collagen type IV alpha-3-binding protein/0.469
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2givACOHistone acetyltransferase KAT8/0.468
2pncCLUPrimary amine oxidase, liver isozyme/0.468
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.468
1drhNAPDihydrofolate reductase1.5.1.30.467
2fznFADBifunctional protein PutA1.5.5.20.467
4hyvPEPPyruvate kinase 12.7.1.400.467
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.466
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.466
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.466
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
4df2FMNNADPH dehydrogenase/0.466
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.466
4yagNAIC alpha-dehydrogenase/0.466
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.466
5efwFMNNPH1-1/0.466
1i6kTYMTryptophan--tRNA ligase6.1.1.20.465
1pd9CO4Dihydrofolate reductase1.5.1.30.465
2cftPLPPyridoxal phosphate phosphatase/0.465
2zhf49UProthrombin3.4.21.50.465
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3gvhNADMalate dehydrogenase/0.465
3h06VBPGlutamate receptor 2/0.465
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.465
4ewo996Beta-secretase 13.4.23.460.465
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.465
4uugPXGBranched-chain amino acid aminotransferase, putative/0.465
1mvsDTMDihydrofolate reductase1.5.1.30.464
2dvlFADAcyl-CoA dehydrogenase/0.464
2gjlFMNNitronate monooxygenase1.13.12.160.464
2rcyNAPPyrroline-5-carboxylate reductase/0.464
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.464
4imfSI3N-acetylneuraminate lyase/0.464
4m4922YL-lactate dehydrogenase A chain1.1.1.270.464
4m6jNDPDihydrofolate reductase1.5.1.30.464
1b8vNADMalate dehydrogenase/0.463
1me6IVSPlasmepsin-23.4.23.390.463
1zgv501Prothrombin3.4.21.50.463
2v1aFMNNPH1-1/0.463
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.463
3drcMTXDihydrofolate reductase1.5.1.30.463
3gqvNAPEnoyl reductase LovC10.463
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.463
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.463
2a94AP0L-lactate dehydrogenase1.1.1.270.462
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.462
2zi224UProthrombin3.4.21.50.462
3atzFMNProstaglandin F2a synthase/0.462
3gviADPMalate dehydrogenase/0.462
3lqfNADGalactitol dehydrogenase/0.462
4a86H35Major pollen allergen Bet v 1-A/0.462
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.462
4g95OAGDihydrofolate reductase1.5.1.30.462
4k6fNAPPutative Acetoacetyl-CoA reductase/0.462
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.462
1h74ADPHomoserine kinase2.7.1.390.461
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.461
2ahrNAPPyrroline-5-carboxylate reductase/0.461
2jh6894Prothrombin3.4.21.50.461
2nniMTKCytochrome P450 2C8/0.461
2pksG44Prothrombin3.4.21.50.461
2v16C47Renin3.4.23.150.461
3aezGDPPantothenate kinase2.7.1.330.461
3b2sB2STrichothecene 3-O-acetyltransferase/0.461
3in6FMNUncharacterized protein/0.461
3oafOAGDihydrofolate reductase1.5.1.30.461
3p0fBAUUridine phosphorylase 22.4.2.30.461
3r95ACOMccE protein/0.461
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.461
4eph0RKCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.461
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
4qaiFMNNADPH dehydrogenase/0.461
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.460
3dzkNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.460
3f7bAG5Carbonic anhydrase 44.2.1.10.460
4m9aFDAAcyl-CoA dehydrogenase/0.460
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.460
1dhfFOLDihydrofolate reductase1.5.1.30.459
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.459
1w6hTITPlasmepsin-23.4.23.390.459
1x8lOXRRetinol dehydratase/0.459
2he5NDPAldo-keto reductase family 1 member C211.1.10.459
2x7hPFNProstaglandin reductase 310.459
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.459
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3ty3GGGHomoisocitrate dehydrogenase1.1.1.870.459
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.459
3v2uATPProtein GAL3/0.459
4a83DXCMajor pollen allergen Bet v 1-A/0.459
4k8s1QTBeta-secretase 13.4.23.460.459
5fsxADPUncharacterized protein/0.459
1guyNADMalate dehydrogenase/0.458
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.458
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.458
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.458
2a9y26AAdenosine kinase2.7.1.200.458
3dziRGTADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.458
3eksCY9Actin-5C/0.458
3tozNADShikimate dehydrogenase (NADP(+))/0.458
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.458
4i1iNADMalate dehydrogenase/0.458
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.458
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.458
8dfrNDPDihydrofolate reductase1.5.1.30.458
1t4u81AProthrombin3.4.21.50.457
2dxdANPNucleoside diphosphate kinase2.7.4.60.457
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.457
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3rdqDTBStreptavidin/0.457
3wswNADL-lactate dehydrogenase/0.457
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.457
4tmcFMNOld yellow enzyme/0.457
5dp2NAPCurF/0.457
1d3dBZTProthrombin3.4.21.50.456
1j49NADD-lactate dehydrogenase1.1.1.280.456
1o5gCR9Prothrombin3.4.21.50.456
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.456
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.456
4dpi0N1Beta-secretase 13.4.23.460.456
4hnc0UTMandelate racemase/0.456
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.456
1g1aNADdTDP-glucose 4,6-dehydratase/0.455
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.455
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.455
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2r2mI50Prothrombin3.4.21.50.455
3s3vTOPDihydrofolate reductase1.5.1.30.455
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.455
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4q71FADBifunctional protein PutA/0.455
4wbdADPPutative cysteine ligase BshC/0.455
1ai9NDPDihydrofolate reductase1.5.1.30.454
1oc1ASVIsopenicillin N synthase1.21.3.10.454
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.454
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.454
2bjfDXCCholoylglycine hydrolase3.5.1.240.454
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2hfuMEVMevalonate kinase/0.454
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.454
3c3nFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.454
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.454
3p0jTYEPutative tyrosyl-tRNA synthetase/0.454
3q33ACOHistone acetyltransferase RTT1092.3.1.480.454
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.454
3qt62P0Mevalonate diphosphate decarboxylase/0.454
3rk1ATPN-type ATP pyrophosphatase superfamily/0.454
3t4eNADQuinate/shikimate dehydrogenase/0.454
4ax9N5NProthrombin3.4.21.50.454
4m83ERYOleandomycin glycosyltransferase2.4.10.454
1dr5NAPDihydrofolate reductase1.5.1.30.453
1eiiRTLRetinol-binding protein 2/0.453
1kqwRTLCellular retinol-binding protein type II/0.453
1psa0ZLPepsin A3.4.23.10.453
1skmSAHModification methylase HhaI2.1.1.370.453
2pswCOAN-alpha-acetyltransferase 50/0.453
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3aosJH2Hemolymph juvenile hormone binding protein/0.453
3axbFADPutative oxidoreductase/0.453
3ekuCY9Actin-5C/0.453
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.453
3qsaTA7Anthranilate phosphoribosyltransferase/0.453
3w6hAZMCarbonic anhydrase 14.2.1.10.453
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.452
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.452
1rx1NAPDihydrofolate reductase1.5.1.30.452
1trgCB3Thymidylate synthase/0.452
1ur5NADMalate dehydrogenase/0.452
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.452
2dhfDZFDihydrofolate reductase1.5.1.30.452
2hk9NAPShikimate dehydrogenase (NADP(+))/0.452
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
2y0mACOHistone acetyltransferase KAT8/0.452
3b70NAPEnoyl reductase LovC10.452
3h2sNDPPutative NADH-flavin reductase/0.452
4h3f10OBeta-secretase 13.4.23.460.452
4r1lADPPhenylacetate-coenzyme A ligase/0.452
4uunNAIL-lactate dehydrogenase/0.452
4ycpFMNtRNA-dihydrouridine(16) synthase/0.452
1culFOKAdenylate cyclase type 2/0.451
1culFOKAdenylate cyclase type 5/0.451
1dr3HBIDihydrofolate reductase1.5.1.30.451
1tl7FOKAdenylate cyclase type 2/0.451
1tl7FOKAdenylate cyclase type 5/0.451
2bslFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.451
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.451
3h3r14HCollagen type IV alpha-3-binding protein/0.451
3h3t16HCollagen type IV alpha-3-binding protein/0.451
3hl0NADMaleylacetate reductase/0.451
3nmpPYVAbscisic acid receptor PYL2/0.451
3owaFADAcyl-CoA dehydrogenase/0.451
3phiNDPShikimate dehydrogenase (NADP(+))/0.451
3wagTYDGlycosyltransferase/0.451
3zcsCAWGlycogen phosphorylase, muscle form2.4.1.10.451
4dc0NDPPutative ketoacyl reductase1.3.10.451
4h3j10WBeta-secretase 13.4.23.460.451
1dhrNADDihydropteridine reductase1.5.1.340.450
1f0xFADD-lactate dehydrogenase1.1.1.280.450
1rrmAPRLactaldehyde reductase1.1.1.770.450
1w0kADPATP synthase subunit alpha, mitochondrial/0.450
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.450
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.450
2aa0MTPAdenosine kinase2.7.1.200.450
2c29NAPDihydroflavonol 4-reductase/0.450
2dteNAIGlucose 1-dehydrogenase related protein/0.450
2ft0ACOdTDP-fucosamine acetyltransferase/0.450
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.450
2gjnFMNNitronate monooxygenase1.13.12.160.450
2uuk897Prothrombin3.4.21.50.450
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.450
3opxU5PSuppressor of disruption of TFIIS/0.450
3zoiM2WIsopenicillin N synthase1.21.3.10.450
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
4lxk1YTBeta-secretase 13.4.23.460.450
4nbwNADShort-chain dehydrogenase/reductase SDR/0.450
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
1bwlFMNNADPH dehydrogenase 11.6.99.10.449
1d3pBT3Prothrombin3.4.21.50.449
1hfqMOTDihydrofolate reductase1.5.1.30.449
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.449
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.449
1rfuADPPyridoxal kinase2.7.1.350.449
2a2xNA9Prothrombin3.4.21.50.449
2hmySAMModification methylase HhaI2.1.1.370.449
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.449
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.449
3c1kT15Prothrombin3.4.21.50.449
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3k5c0BIBeta-secretase 13.4.23.460.449
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4a81DXCMajor pollen allergen Bet v 1-A/0.449
4a862ANMajor pollen allergen Bet v 1-A/0.449
4djy0KRBeta-secretase 13.4.23.460.449
4ht2V50Carbonic anhydrase 124.2.1.10.449
1lquNDPNADPH-ferredoxin reductase FprA1.18.1.20.448
2geuCOKPantothenate kinase2.7.1.330.448
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.448
3a37ADPATPase GET3/0.448
3cgbCOACoenzyme A disulfide reductase/0.448
3dmeFADPutative conserved exported protein/0.448
3fwgCAMCamphor 5-monooxygenase1.14.15.10.448
3gwlFADFAD-linked sulfhydryl oxidase1.8.3.20.448
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.448
3zeiAWHO-acetylserine sulfhydrylase/0.448
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.448
4du82P0Mevalonate diphosphate decarboxylase/0.448
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.448
1c7oPPGHemolysin/0.447
1jwtBLIProthrombin3.4.21.50.447
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.447
1kwqSG1Carbonic anhydrase 24.2.1.10.447
1p0hACOMycothiol acetyltransferase2.3.1.1890.447
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.447
1tllFMNNitric oxide synthase, brain1.14.13.390.447
1towCRZFatty acid-binding protein, adipocyte/0.447
2b3dFADModulator of drug activity B/0.447
2oapANPType II secretion system protein (GspE-2)/0.447
2wu4HBPAcetylcholinesterase3.1.1.70.447
2wzwNDPNitroreductase NfnB/0.447
2xlsNAPPutative flavin-containing monooxygenase/0.447
3biu10UProthrombin3.4.21.50.447
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.447
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.447
4dptAGSMevalonate diphosphate decarboxylase/0.447
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.447
4k9h1QUBeta-secretase 13.4.23.460.447
4o9kCMKArabinose 5-phosphate isomerase/0.447
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.446
1u2yGOXPancreatic alpha-amylase/0.446
2bdyUNBProthrombin3.4.21.50.446
2f3rG5PGuanylate kinase2.7.4.80.446
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.446
2q0kNAPThioredoxin reductase1.8.1.90.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
3qwbNDPProbable quinone oxidoreductase1.6.5.50.446
3vhaVHAHeat shock protein HSP 90-alpha/0.446
4bb3KKAIsopenicillin N synthase1.21.3.10.446
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.446
4exg916Beta-secretase 13.4.23.460.446
4h3g10QBeta-secretase 13.4.23.460.446
1drbMTXDihydrofolate reductase1.5.1.30.445
1iqgXMECoagulation factor X3.4.21.60.445
1juvNDPDihydrofolate reductase1.5.1.30.445
1o9bNAIQuinate/shikimate dehydrogenase/0.445
1p0pBCHCholinesterase3.1.1.80.445
2d81RB3Poly(3-hydroxybutyrate) depolymerase/0.445
2ffqGSPRas-related protein Rab-6B/0.445
2i7pACOPantothenate kinase 32.7.1.330.445
2iviACWIsopenicillin N synthase1.21.3.10.445
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
2w9hTOPDihydrofolate reductase1.5.1.30.445
2xviFADPutative flavin-containing monooxygenase/0.445
2zdv37UProthrombin3.4.21.50.445
2zhe13UProthrombin3.4.21.50.445
3gbuATPUncharacterized sugar kinase PH14592.7.10.445
3opmLUIDipeptidyl peptidase 4/0.445
3p74FMNPentaerythritol tetranitrate reductase/0.445
4j491J1Uncharacterized protein/0.445
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
1a42BZUCarbonic anhydrase 24.2.1.10.444
1a72PADAlcohol dehydrogenase E chain1.1.1.10.444
1j9zFADNADPH--cytochrome P450 reductase/0.444
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.444
1p4aPCPPur operon repressor/0.444
1rxjBNIStreptavidin/0.444
1y7tNDPMalate dehydrogenase/0.444
2a5kAZPReplicase polyprotein 1ab3.4.220.444
2anmCDOProthrombin3.4.21.50.444
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.444
2gtbAZPOrf1ab polyprotein/0.444
2qboCAMCamphor 5-monooxygenase1.14.15.10.444
2w3mFOLDihydrofolate reductase1.5.1.30.444
3c1y2BADNA integrity scanning protein DisA/0.444
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3tfyCOAN-alpha-acetyltransferase 502.3.10.444
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
4fncHMUG/T mismatch-specific thymine DNA glycosylase3.2.2.290.444
4fqsLYAThymidylate synthase ThyA/0.444
4hj6FMNLOV protein/0.444
4j0v1H7Beta-secretase 13.4.23.460.444
4kbyC2EStimulator of interferon genes protein/0.444
4n3l2FNProthrombin3.4.21.50.444
4okw198Androgen receptor/0.444
4twnB96Ephrin type-A receptor 32.7.10.10.444
3vw7VPXProteinase-activated receptor 1/0.444
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1i59ANPChemotaxis protein CheA2.7.13.30.443
1i5cADPChemotaxis protein CheA2.7.13.30.443
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.443
1srjNABStreptavidin/0.443
2c20NADUDP-glucose 4-epimerase/0.443
2np6NEAModification methylase TaqI2.1.1.720.443
2rgoFADAlpha-Glycerophosphate Oxidase/0.443
2whqHI6Acetylcholinesterase3.1.1.70.443
3cz7ACOHistone acetyltransferase RTT1092.3.1.480.443
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.443
3kjgADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3zidGDPTubulin-like protein CetZ/0.443
3zkyWT4Isopenicillin N synthase1.21.3.10.443
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.443
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.443
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.443
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.443
4xfjANPArgininosuccinate synthase/0.443
1eflNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.442
1ia1NDPDihydrofolate reductase1.5.1.30.442
1rx8NAPDihydrofolate reductase1.5.1.30.442
1t2cNAIL-lactate dehydrogenase1.1.1.270.442
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.442
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.442
2q9cGNPSignal recognition particle receptor FtsY/0.442
2qenADPWalker-Type ATPase/0.442
2wf3ZY3Beta-secretase 13.4.23.460.442
3d4pNADL-lactate dehydrogenase 11.1.1.270.442
3gncQQQGlutaryl-CoA dehydrogenase/0.442
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.442
3lpiZ74Beta-secretase 13.4.23.460.442
3oetNADErythronate-4-phosphate dehydrogenase/0.442
3qlsNDPDihydrofolate reductase1.5.1.30.442
3rpeFADPutative modulator of drug activity/0.442
4dpuAGSMevalonate diphosphate decarboxylase/0.442
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
4iarERM5-hydroxytryptamine receptor 1B/0.442
4j3mAJ8Tankyrase-22.4.2.300.442
4oztP1AEcdysone receptor, putative/0.442
4xymCOAAcyl-CoA synthetase (NDP forming)/0.442
5k2cZMAAdenosine receptor A2a/0.442
1dr3TAPDihydrofolate reductase1.5.1.30.441
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1mueCDDProthrombin3.4.21.50.441
1t4v14AProthrombin3.4.21.50.441
1ta6177Prothrombin3.4.21.50.441
2d8aNADL-threonine 3-dehydrogenase/0.441
2g0lFLNNeocarzinostatin/0.441
2rc4ACOHistone acetyltransferase KAT6A/0.441
3c36KAIGlutamate receptor ionotropic, kainate 1/0.441
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3ixp834Ecdysone receptor/0.441
4a4zANPAntiviral helicase SKI23.6.4.130.441
4an4DUDPutative glycosyl transferase/0.441
4fhd0TTSpore photoproduct lyase/0.441
4i9h1E4L-lactate dehydrogenase A chain1.1.1.270.441
4j7hTRHPCZA361.3/0.441
4l4eCAMCamphor 5-monooxygenase1.14.15.10.441
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.441
4q72FADBifunctional protein PutA/0.441
4w5kPLPAspartate aminotransferase, mitochondrial/0.441
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.441
1bmdNADMalate dehydrogenase/0.440
1df7MTXDihydrofolate reductase1.5.1.30.440
1dmyAZMCarbonic anhydrase 5A, mitochondrial4.2.1.10.440
1itzTPPTransketolase, chloroplastic2.2.1.10.440
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.440
1rq1FADEndoplasmic oxidoreductin-11.8.40.440
1u71MXADihydrofolate reductase1.5.1.30.440
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.440
1xddAAYIntegrin alpha-L/0.440
2a84ATPPantothenate synthetase6.3.2.10.440
2hu2NADC-terminal binding protein 1/0.440
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2p4j23IBeta-secretase 13.4.23.460.440
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.440
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3eqlMXPDNA-directed RNA polymerase subunit beta/0.440
3eqlMXPDNA-directed RNA polymerase subunit beta'/0.440
3hdyGDUUDP-galactopyranose mutase/0.440
3nsh957Beta-secretase 13.4.23.460.440
3otwCOAPhosphopantetheine adenylyltransferase/0.440
3q43D66M1 family aminopeptidase3.4.110.440
3q9bB3NAcetylpolyamine amidohydrolase/0.440
3qgf46FGenome polyprotein2.7.7.480.440
3rsv3RSBeta-secretase 13.4.23.460.440
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.440
4b4w9L9Bifunctional protein FolD/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4i0i957Beta-secretase 13.4.23.460.440
4l7vSAHProtein-L-isoaspartate O-methyltransferase/0.440
4nmcFADBifunctional protein PutA/0.440
4pneSAHMethyltransferase-like protein/0.440