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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.11.000
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.530
2wotZZGTGF-beta receptor type-12.7.11.300.523
4c02TAKActivin receptor type-12.7.11.300.523
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.514
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.511
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.508
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.508
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.506
3owj1ELCasein kinase II subunit alpha2.7.11.10.504
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.503
2qo9ANPEphrin type-A receptor 32.7.10.10.503
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.503
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.501
3beaIXHMacrophage colony-stimulating factor 1 receptor2.7.10.10.496
3dogNNNCyclin-dependent kinase 22.7.11.220.496
3qwkX62Cyclin-dependent kinase 22.7.11.220.496
2h55DZ8Heat shock protein HSP 90-alpha/0.495
3rvg17PTyrosine-protein kinase JAK2/0.495
1unlRRCCyclin-dependent-like kinase 52.7.11.10.494
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.494
4f081RSTyrosine-protein kinase JAK2/0.493
1gij2PUCyclin-dependent kinase 22.7.11.220.490
5cvhADPCasein kinase II subunit alpha2.7.11.10.490
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.489
4gub0Y4Casein kinase II subunit alpha2.7.11.10.488
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.488
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.487
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.487
4gmy0X5Tyrosine-protein kinase JAK2/0.487
4okx198Androgen receptor/0.487
1vjy460TGF-beta receptor type-12.7.11.300.486
2wouZZFTGF-beta receptor type-12.7.11.300.486
1g5sI17Cyclin-dependent kinase 22.7.11.220.484
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
4ivd15TTyrosine-protein kinase JAK1/0.484
4ogrADNCyclin-dependent kinase 92.7.11.220.484
1gy3ATPCyclin-dependent kinase 22.7.11.220.483
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.483
3gxlQIGTGF-beta receptor type-12.7.11.300.483
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.483
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.483
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.482
3q9zTXQCasein kinase II subunit alpha2.7.11.10.482
4fx360KCyclin-dependent kinase 22.7.11.220.482
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.482
3qu0X40Cyclin-dependent kinase 22.7.11.220.481
1zrzBI1Protein kinase C iota type2.7.11.130.480
2cchATPCyclin-dependent kinase 22.7.11.220.480
2b7aIZATyrosine-protein kinase JAK2/0.479
4qmpDKISerine/threonine-protein kinase 242.7.11.10.479
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.479
1gih1PUCyclin-dependent kinase 22.7.11.220.478
4aqc88ATyrosine-protein kinase JAK2/0.478
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.478
4c61LMMTyrosine-protein kinase JAK2/0.478
1qmzATPCyclin-dependent kinase 22.7.11.220.477
3qtuX44Cyclin-dependent kinase 22.7.11.220.477
4i3zADPCyclin-dependent kinase 22.7.11.220.477
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.477
1pkdUCNCyclin-dependent kinase 22.7.11.220.476
3rpv26ZCyclin-dependent kinase 22.7.11.220.476
4g2fC07Ephrin type-A receptor 32.7.10.10.476
4ivb1J5Tyrosine-protein kinase JAK1/0.476
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.476
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.475
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.475
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.475
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.475
1oiyN41Cyclin-dependent kinase 22.7.11.220.473
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.473
2hckQUETyrosine-protein kinase HCK2.7.10.20.473
2i40BLZCyclin-dependent kinase 22.7.11.220.473
4aotGW8Serine/threonine-protein kinase 102.7.11.10.473
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.473
1oecAA2Fibroblast growth factor receptor 2/0.472
1rw8580TGF-beta receptor type-12.7.11.300.472
1urwI1PCyclin-dependent kinase 22.7.11.220.472
2jkkBI9Focal adhesion kinase 12.7.10.20.472
2q9fC3SCholesterol 24-hydroxylase/0.472
3oom507Activin receptor type-12.7.11.300.472
3qtzX42Cyclin-dependent kinase 22.7.11.220.472
3rk708ZCyclin-dependent kinase 22.7.11.220.472
4hge15VTyrosine-protein kinase JAK2/0.472
4eol1ROCyclin-dependent kinase 22.7.11.220.471
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.471
1h1r6CPCyclin-dependent kinase 22.7.11.220.470
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.470
3pe2E1BCasein kinase II subunit alpha2.7.11.10.470
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
4fkr45KCyclin-dependent kinase 22.7.11.220.470
4ii5ADPCyclin-dependent kinase 22.7.11.220.470
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.470
1g28FMNPHY3/0.469
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.469
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
3mtfA3FActivin receptor type-12.7.11.300.469
1obnASVIsopenicillin N synthase1.21.3.10.468
1u54ACPActivated CDC42 kinase 1/0.468
1vyw292Cyclin-dependent kinase 22.7.11.220.468
2wpa889Cyclin-dependent kinase 22.7.11.220.468
3fz1B98Cyclin-dependent kinase 22.7.11.220.468
4bcoT6QCyclin-dependent kinase 22.7.11.220.468
4dymIYZActivin receptor type-12.7.11.300.468
1lp4ANPCasein kinase II subunit alpha2.7.11.10.467
1m2qMNXCasein kinase II subunit alpha2.7.11.10.467
2qbmCAMCamphor 5-monooxygenase1.14.15.10.467
3r7vZ02Cyclin-dependent kinase 22.7.11.220.467
3rak03ZCyclin-dependent kinase 22.7.11.220.467
3s1dZIRCytokinin dehydrogenase 11.5.99.120.467
4erwSTUCyclin-dependent kinase 22.7.11.220.467
4gk3L87Ephrin type-A receptor 32.7.10.10.467
5e8wSTUTGF-beta receptor type-12.7.11.300.467
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1h1s4SPCyclin-dependent kinase 22.7.11.220.466
1nooCAHCamphor 5-monooxygenase1.14.15.10.466
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.466
3at3ATKCasein kinase II subunit alpha2.7.11.10.466
3ddpRC8Cyclin-dependent kinase 22.7.11.220.466
3mtlFEFCyclin-dependent kinase 162.7.11.220.466
3qtrX36Cyclin-dependent kinase 22.7.11.220.466
3ral04ZCyclin-dependent kinase 22.7.11.220.466
4dgo0JWCasein kinase II subunit alpha2.7.11.10.466
4nj32KDCyclin-dependent kinase 22.7.11.220.466
1dawANPCasein kinase II subunit alpha2.7.11.10.465
1oguST8Cyclin-dependent kinase 22.7.11.220.465
2uzlC94Cyclin-dependent kinase 22.7.11.220.465
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.465
3h4vNAPPteridine reductase 11.5.1.330.465
3nga3NGCasein kinase II subunit alpha2.7.11.10.465
3r0tFU9Casein kinase II subunit alpha2.7.11.10.465
3vryB43Tyrosine-protein kinase HCK2.7.10.20.465
4eor4SPCyclin-dependent kinase 22.7.11.220.465
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
5cvcPLPSerine racemase/0.465
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1jpaANPEphrin type-B receptor 22.7.10.10.464
2w17I19Cyclin-dependent kinase 22.7.11.220.464
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.464
3b9lAZZSerum albumin/0.464
3bhtMFRCyclin-dependent kinase 22.7.11.220.464
3gbuATPUncharacterized sugar kinase PH14592.7.10.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
3hx4ANPCalmodulin-domain protein kinase 1/0.464
1uydPU8Heat shock protein HSP 90-alpha/0.463
2vttLZDCyclin-dependent kinase 22.7.11.220.463
3dd125DGlycogen phosphorylase, liver form2.4.1.10.463
3roy22ZCyclin-dependent kinase 22.7.11.220.463
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.463
4prvADPDNA gyrase subunit B/0.463
1oiuN76Cyclin-dependent kinase 22.7.11.220.462
2pmoHMDProtein kinase 7/0.462
2qocANPEphrin type-A receptor 32.7.10.10.462
2xb7GUIALK tyrosine kinase receptor2.7.10.10.462
3ibqATPPyridoxal kinase/0.462
3oibFDAPutative acyl-CoA dehydrogenase/0.462
4anmWULCasein kinase II subunit alpha2.7.11.10.462
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1t85CAMCamphor 5-monooxygenase1.14.15.10.461
2iw94SPCyclin-dependent kinase 22.7.11.220.461
2nniMTKCytochrome P450 2C8/0.461
2vbdV10Isopenicillin N synthase1.21.3.10.461
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
3zep1NXTyrosine-protein kinase JAK32.7.10.20.461
4bgg844Activin receptor type-12.7.11.300.461
4eomATPCyclin-dependent kinase 22.7.11.220.461
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.461
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.461
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.461
1i59ANPChemotaxis protein CheA2.7.13.30.460
2bkzSBCCyclin-dependent kinase 22.7.11.220.460
2iw84SPCyclin-dependent kinase 22.7.11.220.460
2r3p3SCCyclin-dependent kinase 22.7.11.220.460
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.460
3r1yX76Cyclin-dependent kinase 22.7.11.220.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.460
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4bcpT3CCyclin-dependent kinase 22.7.11.220.460
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.460
4riyADPEpidermal growth factor receptor2.7.10.10.460
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.460
1bk0ACVIsopenicillin N synthase1.21.3.10.459
1bwsNDPGDP-L-fucose synthase/0.459
2c6o4SPCyclin-dependent kinase 22.7.11.220.459
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.459
2qo7ANPEphrin type-A receptor 32.7.10.10.459
2rkvZBATrichothecene 3-O-acetyltransferase/0.459
2xneASHAurora kinase A2.7.11.10.459
3fwjCAMCamphor 5-monooxygenase1.14.15.10.459
3s2pPMUCyclin-dependent kinase 22.7.11.220.459
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.459
3zh8C58Protein kinase C iota type2.7.11.130.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4gk2L66Ephrin type-A receptor 32.7.10.10.459
4iva1J5Tyrosine-protein kinase JAK2/0.459
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.459
4k771Q4Tyrosine-protein kinase JAK1/0.459
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.459
1di8DTQCyclin-dependent kinase 22.7.11.220.458
1ke6LS2Cyclin-dependent kinase 22.7.11.220.458
1oi9N20Cyclin-dependent kinase 22.7.11.220.458
1rfuADPPyridoxal kinase2.7.1.350.458
2c5nCK8Cyclin-dependent kinase 22.7.11.220.458
2v7a627Tyrosine-protein kinase ABL12.7.10.20.458
3ih0ANPUncharacterized sugar kinase PH14592.7.10.458
4m15ADPTyrosine-protein kinase ITK/TSK2.7.10.20.458
4q71FADBifunctional protein PutA/0.458
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.457
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
2py3ACPFibroblast growth factor receptor 2/0.457
2zjwREFCasein kinase II subunit alpha2.7.11.10.457
3ig7EFPCyclin-dependent kinase 22.7.11.220.457
3iok1P6Tyrosine-protein kinase JAK2/0.457
3raiX85Cyclin-dependent kinase 22.7.11.220.457
3sqq99ZCyclin-dependent kinase 22.7.11.220.457
3tnwF18Cyclin-dependent kinase 22.7.11.220.457
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.457
4qmySTUSerine/threonine-protein kinase 242.7.11.10.457
5e8xSTUTGF-beta receptor type-12.7.11.300.457
1cqp803Integrin alpha-L/0.456
1dz8CAMCamphor 5-monooxygenase1.14.15.10.456
1p2a5BNCyclin-dependent kinase 22.7.11.220.456
1zdwFLVPrenyltransferase/0.456
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2btsU32Cyclin-dependent kinase 22.7.11.220.456
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2in6839Wee1-like protein kinase2.7.10.20.456
2o2sTCLEnoyl-acyl carrier reductase/0.456
2wxvWXVCyclin-dependent kinase 22.7.11.220.456
3zmmF9JTyrosine-protein kinase JAK2/0.456
3zze6XPHepatocyte growth factor receptor2.7.10.10.456
4fks46KCyclin-dependent kinase 22.7.11.220.456
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.456
4gk4L90Ephrin type-A receptor 32.7.10.10.456
4l4eCAMCamphor 5-monooxygenase1.14.15.10.456
6cp4CAMCamphor 5-monooxygenase1.14.15.10.456
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1ke8LS4Cyclin-dependent kinase 22.7.11.220.455
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.455
2b55D31Cyclin-dependent kinase 22.7.11.220.455
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.455
2gr1FADFerredoxin reductase/0.455
2x1nX1NCyclin-dependent kinase 22.7.11.220.455
2y6fM9FIsopenicillin N synthase1.21.3.10.455
3cukFADD-amino-acid oxidase1.4.3.30.455
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3ql8X01Cyclin-dependent kinase 22.7.11.220.455
3qqfX07Cyclin-dependent kinase 22.7.11.220.455
3r73X87Cyclin-dependent kinase 22.7.11.220.455
4q72FADBifunctional protein PutA/0.455
4r1lADPPhenylacetate-coenzyme A ligase/0.455
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
1me6IVSPlasmepsin-23.4.23.390.454
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2m56CAMCamphor 5-monooxygenase1.14.15.10.454
3fwgCAMCamphor 5-monooxygenase1.14.15.10.454
3p62FMNPentaerythritol tetranitrate reductase/0.454
3qqkX02Cyclin-dependent kinase 22.7.11.220.454
3r7iX9ICyclin-dependent kinase 22.7.11.220.454
3vt8YI3Vitamin D3 receptor/0.454
4bbfO19Tyrosine-protein kinase JAK2/0.454
4bgh3I6Cyclin-dependent kinase 22.7.11.220.454
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.454
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.454
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.453
2c5yMTWCyclin-dependent kinase 22.7.11.220.453
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.453
2pvlP55Casein kinase II subunit alpha2.7.11.10.453
2rhgIGPTryptophan synthase alpha chain/0.453
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
3r1qX75Cyclin-dependent kinase 22.7.11.220.453
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.453
4acm7YGCyclin-dependent kinase 22.7.11.220.453
4bcqTJFCyclin-dependent kinase 22.7.11.220.453
5e92ANPTGF-beta receptor type-22.7.11.300.453
1nzdUPGDNA beta-glucosyltransferase/0.452
1xddAAYIntegrin alpha-L/0.452
1xdpATPPolyphosphate kinase/0.452
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2hk9NAPShikimate dehydrogenase (NADP(+))/0.452
2vv9IM9Cyclin-dependent kinase 22.7.11.220.452
2vzzSCAPutative succinyl-CoA transferase Rv0802c2.8.30.452
3cisATPUniversal stress protein Rv2623/0.452
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4fvqATPTyrosine-protein kinase JAK2/0.452
4hvh19RTyrosine-protein kinase JAK32.7.10.20.452
4x5iFOLDihydrofolate reductase1.5.1.30.452
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.451
1dz6CAMCamphor 5-monooxygenase1.14.15.10.451
1jstATPCyclin-dependent kinase 22.7.11.220.451
1uy6PU3Heat shock protein HSP 90-alpha/0.451
1uyhPU0Heat shock protein HSP 90-alpha/0.451
2henADPEphrin type-B receptor 22.7.10.10.451
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.451
2pmlANPUncharacterized protein/0.451
2qblCAMCamphor 5-monooxygenase1.14.15.10.451
2w06FRVCyclin-dependent kinase 22.7.11.220.451
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2xmyCDKCyclin-dependent kinase 22.7.11.220.451
2yn8STUEphrin type-B receptor 42.7.10.10.451
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.451
3cgcCOACoenzyme A disulfide reductase/0.451
3lfsA07Cyclin-dependent kinase 22.7.11.220.451
3mqe416Prostaglandin G/H synthase 21.14.99.10.451
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.451
3qzhX69Cyclin-dependent kinase 22.7.11.220.451
3r1sX73Cyclin-dependent kinase 22.7.11.220.451
3rmf20ZCyclin-dependent kinase 22.7.11.220.451
4jqh1MFAlr2278 protein/0.451
4k33ACPFibroblast growth factor receptor 32.7.10.10.451
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.451
5cshATPCasein kinase II subunit alpha2.7.11.10.451
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.450
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.450
1xl2189Gag-Pol polyprotein3.4.23.160.450
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.450
2pz5ACPFibroblast growth factor receptor 2/0.450
2q29ACOOxalyl-CoA decarboxylase4.1.1.80.450
2qtvGNPSmall COPII coat GTPase SAR13.6.50.450
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.450
2w05FRTCyclin-dependent kinase 22.7.11.220.450
2xa4AZ5Tyrosine-protein kinase JAK2/0.450
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.450
2zbaZBATrichothecene 3-O-acetyltransferase/0.450
3hmm855TGF-beta receptor type-12.7.11.300.450
3mdvCL6Cholesterol 24-hydroxylase/0.450
3r6xX84Cyclin-dependent kinase 22.7.11.220.450
3r7eX88Cyclin-dependent kinase 22.7.11.220.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ez30S0Cyclin-dependent kinase 22.7.11.220.450
4ez50RSCyclin-dependent kinase 62.7.11.220.450
4f09JAKTyrosine-protein kinase JAK2/0.450
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.450
4oal245Cytokinin dehydrogenase 4/0.450
4tuvCPZCytochrome P450 1191.140.450
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
2bhhRYUCyclin-dependent kinase 22.7.11.220.449
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.449
2gqtFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.449
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.449
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.449
2uzeC95Cyclin-dependent kinase 22.7.11.220.449
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.449
3hz142CHeat shock protein HSP 90-alpha/0.449
3lq5SLQCyclin-dependent kinase 92.7.11.220.449
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.449
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4ei40Q2Tyrosine-protein kinase JAK1/0.449
4l4fCAMCamphor 5-monooxygenase1.14.15.10.449
4o95245Cytokinin dehydrogenase 4/0.449
4rupH97Vitamin D3 receptor A/0.449
1ie8KH1Vitamin D3 receptor/0.448
1p0hACOMycothiol acetyltransferase2.3.1.1890.448
1rx8NAPDihydrofolate reductase1.5.1.30.448
1u4dDBQActivated CDC42 kinase 1/0.448
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.448
2fy4COACholine O-acetyltransferase2.3.1.60.448
2nnqT4BFatty acid-binding protein, adipocyte/0.448
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.448
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.448
2xvw9NRSerum albumin/0.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.448
3eljGS7Mitogen-activated protein kinase 82.7.11.240.448
3hekBD0Heat shock protein HSP 90-alpha/0.448
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.448
3rni21ZCyclin-dependent kinase 22.7.11.220.448
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.448
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.448
4jqeANPCasein kinase II subunit alpha2.7.11.10.448
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.448
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.448
1blzACVIsopenicillin N synthase1.21.3.10.447
1cjkFOKAdenylate cyclase type 2/0.447
1cjkFOKAdenylate cyclase type 5/0.447
1ckpPVBCyclin-dependent kinase 22.7.11.220.447
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1fvt106Cyclin-dependent kinase 22.7.11.220.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1m2pHNACasein kinase II subunit alpha2.7.11.10.447
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.447
1y91CT9Cyclin-dependent kinase 22.7.11.220.447
2bunFADAppA protein/0.447
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.447
2izuP01Casein kinase I isoform gamma-32.7.11.10.447
2nq8ZIDEnoyl-ACP reductase/0.447
2p5uNADUDP-glucose 4-epimerase/0.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
2zdt46CMitogen-activated protein kinase 102.7.11.240.447
3biz61EWee1-like protein kinase2.7.10.20.447
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.447
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3rkb12ZCyclin-dependent kinase 22.7.11.220.447
3s1h56ZCyclin-dependent kinase 22.7.11.220.447
3uli1N3Cyclin-dependent kinase 22.7.11.220.447
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.447
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.447
4dbzNDPPutative ketoacyl reductase1.3.10.447
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.447
4qysPLRTryptophan synthase beta chain 24.2.1.200.447
3sn6P0GBeta-2 adrenergic receptor/0.447
1eyqNARChalcone--flavonone isomerase 15.5.1.60.446
1fvv107Cyclin-dependent kinase 22.7.11.220.446
1mewXMPInosine-5'-monophosphate dehydrogenase/0.446
1oitHDTCyclin-dependent kinase 22.7.11.220.446
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.446
1x8lOXRRetinol dehydratase/0.446
1yrdCAMCamphor 5-monooxygenase1.14.15.10.446
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.446
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.446
2ignFADPyranose 2-oxidase/0.446
2uzbC75Cyclin-dependent kinase 22.7.11.220.446
2yeiXQIHeat shock protein HSP 90-alpha/0.446
3dds26BGlycogen phosphorylase, liver form2.4.1.10.446
3mdmFJZCholesterol 24-hydroxylase/0.446
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3qrtX14Cyclin-dependent kinase 22.7.11.220.446
3qxpX64Cyclin-dependent kinase 22.7.11.220.446
3rk909ZCyclin-dependent kinase 22.7.11.220.446
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
3wblPDYCyclin-dependent kinase 22.7.11.220.446
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.446
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4e4l0NHTyrosine-protein kinase JAK1/0.446
4e6q0NVTyrosine-protein kinase JAK2/0.446
4ewhT77Activated CDC42 kinase 1/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.446
4g3rCAMCamphor 5-monooxygenase1.14.15.10.446
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.446
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.446
4qmzB49Serine/threonine-protein kinase 242.7.11.10.446
1aq1STUCyclin-dependent kinase 22.7.11.220.445
1eh4IC1Casein kinase I homolog 12.7.11.10.445
1gii1PUCyclin-dependent kinase 22.7.11.220.445
1rfvADPPyridoxal kinase2.7.1.350.445
1uyePU9Heat shock protein HSP 90-alpha/0.445
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.445
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.445
2eufLQQCyclin-dependent kinase 62.7.11.220.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2ykeYKEHeat shock protein HSP 90-alpha/0.445
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
3ixp834Ecdysone receptor/0.445
3q3cNADNAD-dependent L-serine dehydrogenase/0.445
3qruX19Cyclin-dependent kinase 22.7.11.220.445
3zpuM8BGag-Pol polyprotein3.4.23.160.445
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
4enhFVXCholesterol 24-hydroxylase/0.445
4fki09KCyclin-dependent kinase 22.7.11.220.445
4iteTEYVitamin D3 receptor/0.445
4n6hEJ4Delta-type opioid receptor/0.445
4y9lFADAcyl-CoA dehydrogenase family member 11/0.445
5a9sNAPPutative dehydrogenase/0.445
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.444
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1r2jFADFkbI/0.444
1ykdCMPAdenylate cyclase/0.444
2b56UTPRNA editing complex protein MP57/0.444
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2fvdLIACyclin-dependent kinase 22.7.11.220.444
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.444
2j9mPY8Cyclin-dependent kinase 22.7.11.220.444
2pywADPMethylthioribose kinase2.7.1.1000.444
2vagV25Dual specificity protein kinase CLK12.7.12.10.444
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.444
3b2tM33Fibroblast growth factor receptor 2/0.444
3bfb9ODPheromone-binding protein ASP1/0.444
3bw4FMNPutative 2-nitropropane dioxygenase/0.444
3eb0DRKUncharacterized protein/0.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.444
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.444
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3vrwYS5Vitamin D3 receptor/0.444
3wowANPCasein kinase II subunit alpha2.7.11.10.444
3zls92PDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
4cdmFO1Deoxyribodipyrimidine photolyase/0.444
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4eon1ROCyclin-dependent kinase 22.7.11.220.444
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4jr7GNPCasein kinase II subunit alpha2.7.11.10.444
1nzfUPGDNA beta-glucosyltransferase/0.443
2b1pAIZMitogen-activated protein kinase 102.7.11.240.443
2c6iDT1Cyclin-dependent kinase 22.7.11.220.443
2qg2A91Heat shock protein HSP 90-alpha/0.443
2z4sADPChromosomal replication initiator protein DnaA/0.443
3a4pDFQHepatocyte growth factor receptor2.7.10.10.443
3och2MXDihydrofolate reductase1.5.1.30.443
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3oriAGSSerine/threonine protein kinase/0.443
3r28XA0Cyclin-dependent kinase 22.7.11.220.443
3rm618ZCyclin-dependent kinase 22.7.11.220.443
3rm719ZCyclin-dependent kinase 22.7.11.220.443
3sw418KCyclin-dependent kinase 22.7.11.220.443
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.443
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.443
4iae1DXAlr2278 protein/0.443
4iah1DXAlr2278 protein/0.443
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.443
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.443
4yekTHMThymidine phosphorylase/0.443
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.442
1h1pCMGCyclin-dependent kinase 22.7.11.220.442
1ke7LS3Cyclin-dependent kinase 22.7.11.220.442
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1yvj4STTyrosine-protein kinase JAK32.7.10.20.442
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.442
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.442
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.442
2f2uM77Rho-associated protein kinase 22.7.11.10.442
2pzpACPFibroblast growth factor receptor 2/0.442
2r3kSCQCyclin-dependent kinase 22.7.11.220.442
2r64740Cyclin-dependent kinase 22.7.11.220.442
2xpwOTCTetracycline repressor protein class D/0.442
3hz137DHeat shock protein HSP 90-alpha/0.442
3mjeNDPAmphB/0.442
3pj8404Cyclin-dependent kinase 22.7.11.220.442
4dcaADPAminoglycoside phosphotransferase/0.442
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.442
4hj6FMNLOV protein/0.442
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.442
4ia3BIVVitamin D3 receptor A/0.442
1csnATPCasein kinase I homolog 12.7.11.10.441
1cx2S58Prostaglandin G/H synthase 21.14.99.10.441
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1ke9LS5Cyclin-dependent kinase 22.7.11.220.441
1rx8FOLDihydrofolate reductase1.5.1.30.441
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.441
1vyzN5BCyclin-dependent kinase 22.7.11.220.441
2b52D42Cyclin-dependent kinase 22.7.11.220.441
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.441
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.441
2f2cAP9Cyclin-dependent kinase 62.7.11.220.441
2pwlACPFibroblast growth factor receptor 2/0.441
2qboCAMCamphor 5-monooxygenase1.14.15.10.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
2zaxCAMCamphor 5-monooxygenase1.14.15.10.441
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.441
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3d84NDPDihydrofolate reductase1.5.1.30.441
3nr4PYVAbscisic acid receptor PYL2/0.441
3qtqX35Cyclin-dependent kinase 22.7.11.220.441
3r8zZ63Cyclin-dependent kinase 22.7.11.220.441
3r9dX6BCyclin-dependent kinase 22.7.11.220.441
3rjc06ZCyclin-dependent kinase 22.7.11.220.441
3s79ASDAromatase1.14.14.140.441
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.441
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.441
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.441
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.441
4o71CPBBromodomain-containing protein 4/0.441
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.441
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1cbsREACellular retinoic acid-binding protein 2/0.440
1cs4FOKAdenylate cyclase type 2/0.440
1cs4FOKAdenylate cyclase type 5/0.440
1dhiMTXDihydrofolate reductase1.5.1.30.440
1fkwPURAdenosine deaminase3.5.4.40.440
1j4jACOAcetyltransferase2.3.10.440
1uycPU7Heat shock protein HSP 90-alpha/0.440
1xjdSTUProtein kinase C theta type2.7.11.130.440
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
2pwcG3GGag-Pol polyprotein3.4.23.160.440
2v5aLZLBiotin carboxylase6.3.4.140.440
2vwz7X6Ephrin type-B receptor 42.7.10.10.440
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.440
3a1nNADNDP-sugar epimerase/0.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3kjm245Cytokinin dehydrogenase 11.5.99.120.440
3p4tFAOPutative acyl-CoA dehydrogenase/0.440
3rpy27ZCyclin-dependent kinase 22.7.11.220.440
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3zuyTCHTransporter/0.440
4aknS5BBromodomain-containing protein 2/0.440
4awp99AHeat shock protein HSP 90-alpha/0.440
4c62XWWTyrosine-protein kinase JAK2/0.440
4cfnJYMCyclin-dependent kinase 22.7.11.220.440
4du82P0Mevalonate diphosphate decarboxylase/0.440
4e5yNDPGDP-L-fucose synthase1.1.1.2710.440
4eok4SPCyclin-dependent kinase 22.7.11.220.440
4eos1ROCyclin-dependent kinase 22.7.11.220.440
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
4g2rH1LProbable propionyl-CoA carboxylase beta chain 66.4.1.30.440
4hy6FJ1Heat shock protein HSP 90-alpha/0.440
4jboWPHAurora kinase A2.7.11.10.440
4jlj1NMDeoxycytidine kinase2.7.1.740.440
4mv1ADPBiotin carboxylase6.3.4.140.440
4nk92K5Fibroblast growth factor receptor 1/0.440
4ruoBIVVitamin D3 receptor A/0.440