sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 1.000 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.555 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.528 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.514 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.497 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.495 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.493 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.491 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.490 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.484 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.484 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.483 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.482 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.481 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.481 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.481 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.480 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.479 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.479 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.478 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.478 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.478 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.478 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.478 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.478 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.477 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.476 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.475 | |
| 1qvn | FRI | Interleukin-2 | / | 0.474 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.474 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.474 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.474 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.474 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.474 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.472 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.472 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.472 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.471 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.471 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.471 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.471 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.470 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.469 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.469 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.469 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.468 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.468 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.468 | |
| 3g0f | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.468 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.468 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.466 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.466 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.466 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.466 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.465 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.465 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.465 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.464 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.464 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.464 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.463 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.463 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.463 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.463 | |
| 2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.463 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.463 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.463 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.462 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.462 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.461 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.461 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.460 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 3t9i | 3T9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.460 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.460 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.460 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.460 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.460 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.459 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.459 | |
| 2i1m | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.459 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.459 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.459 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.459 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.458 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.458 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.458 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.458 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.458 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.458 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 2qu5 | 276 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.457 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.457 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.457 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.457 | |
| 4l9q | 9TP | Serum albumin | / | 0.457 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.456 | |
| 1swt | BTN | Streptavidin | / | 0.456 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.456 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.456 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.456 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3up3 | XCA | aceDAF-12 | / | 0.456 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.455 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.455 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.455 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.455 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.455 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.455 | |
| 5a3c | NAD | SIR2 family protein | / | 0.455 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.455 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.455 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.455 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.454 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.454 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.454 | |
| 4l8u | 9AZ | Serum albumin | / | 0.454 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 1nht | PGS | Adenylosuccinate synthetase | / | 0.453 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.453 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.453 | |
| 3lmg | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.453 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.453 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.453 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.452 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.452 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.452 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.452 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.451 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.451 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.451 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.451 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.451 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.451 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.451 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3liv | E16 | Protease | / | 0.450 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.450 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.450 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.450 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.450 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.450 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.450 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.450 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.450 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 4uya | AGS | Mitogen-activated protein kinase kinase kinase 21 | 2.7.11.25 | 0.450 | |
| 5dp2 | NAP | CurF | / | 0.450 | |
| 1fbm | RTL | Cartilage oligomeric matrix protein | / | 0.449 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.449 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.449 | |
| 1osv | CHC | Bile acid receptor | / | 0.449 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.449 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.449 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.449 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.449 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3zk6 | H1I | Bcl-2-like protein 1 | / | 0.449 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.449 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.449 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.448 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.448 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3eek | 53S | Uncharacterized protein | / | 0.448 | |
| 3nfa | CBJ | Gag-Pol polyprotein | / | 0.448 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.448 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.448 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.448 | |
| 4agc | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.448 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.448 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.447 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.447 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.447 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.447 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.447 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.447 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.447 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.447 | |
| 5cds | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.446 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.446 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.446 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.445 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.445 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.445 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.445 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.445 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 4fst | HK4 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.444 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.444 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.444 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.444 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.444 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3eel | 53T | Uncharacterized protein | / | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3iaf | TPP | Benzaldehyde lyase | / | 0.444 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.444 | |
| 3up0 | D7S | aceDAF-12 | / | 0.444 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.444 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.444 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.444 | |
| 4i5h | G17 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 4njt | 017 | Protease | / | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 5cdg | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1cde | DZF | Phosphoribosylglycinamide formyltransferase | / | 0.443 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.443 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.443 | |
| 3iw7 | IPK | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.443 | |
| 4cjw | CBJ | Integrase | / | 0.443 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4pd6 | URI | Nucleoside permease | / | 0.443 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.443 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 1c6y | MK1 | Protease | / | 0.442 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.442 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
| 1me7 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.442 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.442 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.442 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.442 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.442 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.442 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.442 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3ori | AGS | Serine/threonine protein kinase | / | 0.442 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.442 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.442 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.442 | |
| 5c3z | ACP | Ribokinase | / | 0.442 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.442 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.441 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1hw5 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.441 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.441 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.441 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1nde | MON | Estrogen receptor beta | / | 0.441 | |
| 1nq2 | 4HY | Thyroid hormone receptor beta | / | 0.441 | |
| 1ppj | ANY | Cytochrome b | / | 0.441 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.441 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.441 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.441 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.441 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.441 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.441 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.441 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.441 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.441 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.441 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.441 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.441 | |
| 1b6k | PI5 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.440 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.440 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.440 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.440 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.440 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.440 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.440 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |