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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hy81STSerine/threonine-protein kinase PAK 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2hy81STSerine/threonine-protein kinase PAK 12.7.11.11.000
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.515
4gmy0X5Tyrosine-protein kinase JAK2/0.504
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.502
3zep1NXTyrosine-protein kinase JAK32.7.10.20.498
4qnaX11Serine/threonine-protein kinase 242.7.11.10.497
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.492
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.491
3zh8C58Protein kinase C iota type2.7.11.130.490
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.489
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.485
2in6839Wee1-like protein kinase2.7.10.20.485
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.484
4jia1K3Tyrosine-protein kinase JAK2/0.483
3a7hATPSerine/threonine-protein kinase 242.7.11.10.481
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.480
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.479
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.478
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.478
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.477
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.476
3at4CCKCasein kinase II subunit alpha2.7.11.10.475
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.473
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
2hog710Serine/threonine-protein kinase Chk12.7.11.10.471
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.471
4jqeANPCasein kinase II subunit alpha2.7.11.10.471
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.467
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.467
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.465
4qmlANPSerine/threonine-protein kinase 242.7.11.10.465
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.463
4qmpDKISerine/threonine-protein kinase 242.7.11.10.463
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.462
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.462
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.461
3gxlQIGTGF-beta receptor type-12.7.11.300.461
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.461
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.460
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.459
2vd5BI8Myotonin-protein kinase2.7.11.10.459
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.459
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.459
4nka2K7Fibroblast growth factor receptor 1/0.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.458
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.458
2qo9ANPEphrin type-A receptor 32.7.10.10.458
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.457
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.456
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.456
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
3t8oATPRhodopsin kinase/0.456
4grb0XGCasein kinase II subunit alpha2.7.11.10.456
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
4hgs15GCasein kinase I isoform gamma-32.7.11.10.455
4hvi19STyrosine-protein kinase JAK32.7.10.20.455
4qmzB49Serine/threonine-protein kinase 242.7.11.10.455
2izrBRKCasein kinase I isoform gamma-32.7.11.10.454
2yn8STUEphrin type-B receptor 42.7.10.10.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.454
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.454
4hvh19RTyrosine-protein kinase JAK32.7.10.20.454
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.453
1x8b824Wee1-like protein kinase2.7.10.20.453
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.453
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.453
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.453
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.453
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.453
4g170VNCasein kinase I isoform gamma-32.7.11.10.453
2z2w770Wee1-like protein kinase2.7.10.20.452
3cr0809Wee1-like protein kinase2.7.10.20.452
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1bygSTUTyrosine-protein kinase CSK/0.451
1pkdUCNCyclin-dependent kinase 22.7.11.220.451
3ggfGVDSerine/threonine-protein kinase 26/0.451
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.451
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4dgo0JWCasein kinase II subunit alpha2.7.11.10.451
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2x6dX6DAurora kinase A2.7.11.10.450
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.450
4e4m0NHTyrosine-protein kinase JAK2/0.450
4j97ACPFibroblast growth factor receptor 2/0.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.449
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.449
3axwTIDCasein kinase II subunit alpha2.7.11.10.449
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.449
3umw596Serine/threonine-protein kinase pim-12.7.11.10.449
2izuP01Casein kinase I isoform gamma-32.7.11.10.448
2pvnP63Casein kinase II subunit alpha2.7.11.10.448
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.448
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.447
4bcmT7ZCyclin-dependent kinase 22.7.11.220.447
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
5auwQUEDeath-associated protein kinase 12.7.11.10.446
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.445
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.445
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.445
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.444
1wvxBD4Death-associated protein kinase 12.7.11.10.444
3il1B5DGlutamate receptor 2/0.444
3js2VM1Fibroblast growth factor receptor 1/0.444
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.444
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.444
2csnCKICasein kinase I homolog 12.7.11.10.443
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.443
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.443
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
2j0m4STFocal adhesion kinase 12.7.10.20.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.442
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.441
3a7jADPSerine/threonine-protein kinase 242.7.11.10.441
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.441
3q9xEMOCasein kinase II subunit alpha2.7.11.10.441
4wboANWRhodopsin kinase/0.441
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.440
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
3u4uLNHCasein kinase II subunit alpha2.7.11.10.440
4c61LMMTyrosine-protein kinase JAK2/0.440
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.440