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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hr8SAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2hr8SAHDiphthine synthase/1.000
2huqSAHDiphthine synthase/0.660
2e16SAHDiphthine synthase/0.659
2ed5SAHDiphthine synthase/0.658
1vceSAHDiphthine synthase/0.655
1wngSAHDiphthine synthase/0.652
2p5fSAHDiphthine synthase/0.652
2egbSAHDiphthine synthase/0.650
2eglSAHDiphthine synthase/0.650
2ek3SAHDiphthine synthase/0.648
2el0SAHDiphthine synthase/0.648
2owgSAHDiphthine synthase/0.646
2owkSAHDiphthine synthase/0.646
2eh2SAHDiphthine synthase/0.645
2pcaSAHDiphthine synthase/0.645
2p2xSAHDiphthine synthase/0.644
2dekSAHDiphthine synthase/0.642
2dxxSAHDiphthine synthase/0.642
2p9dSAHDiphthine synthase/0.641
2eh5SAHDiphthine synthase/0.639
2e08SAHDiphthine synthase/0.638
2eh4SAHDiphthine synthase/0.637
2ehlSAHDiphthine synthase/0.637
2dv7SAHDiphthine synthase/0.636
2egsSAHDiphthine synthase/0.636
2e8qSAHDiphthine synthase/0.634
2dxvSAHDiphthine synthase/0.633
2e07SAHDiphthine synthase/0.632
2huvSAHDiphthine synthase/0.632
2eleSAHDiphthine synthase/0.631
2hutSAHDiphthine synthase/0.631
2z6rSAHDiphthine synthase/0.631
2ejkSAHDiphthine synthase/0.627
2emuSAHDiphthine synthase/0.627
2e8rSAHDiphthine synthase/0.626
2emrSAHDiphthine synthase/0.626
2owuSAHDiphthine synthase/0.626
2dxwSAHDiphthine synthase/0.625
2p5cSAHDiphthine synthase/0.625
2e15SAHDiphthine synthase/0.624
2e7rSAHDiphthine synthase/0.624
2e8hSAHDiphthine synthase/0.624
2eniSAHDiphthine synthase/0.624
2pchSAHDiphthine synthase/0.624
2dv5SAHDiphthine synthase/0.623
2huxSAHDiphthine synthase/0.622
2owvSAHDiphthine synthase/0.622
2pcgSAHDiphthine synthase/0.621
2dv3SAHDiphthine synthase/0.620
2en5SAHDiphthine synthase/0.620
2pb6SAHDiphthine synthase/0.620
2el3SAHDiphthine synthase/0.617
2p6iSAHDiphthine synthase/0.617
2e17SAHDiphthine synthase/0.616
2dshSAHDiphthine synthase/0.615
2e4nSAHDiphthine synthase/0.615
2ejjSAHDiphthine synthase/0.615
2eldSAHDiphthine synthase/0.614
2pcmSAHDiphthine synthase/0.614
2pb4SAHDiphthine synthase/0.613
2ek2SAHDiphthine synthase/0.612
2ekaSAHDiphthine synthase/0.609
2dv4SAHDiphthine synthase/0.608
2p6dSAHDiphthine synthase/0.608
2ek7SAHDiphthine synthase/0.605
2p6kSAHDiphthine synthase/0.605
2dsgSAHDiphthine synthase/0.603
2pckSAHDiphthine synthase/0.603
2ed3SAHDiphthine synthase/0.598
2dsiSAHDiphthine synthase/0.594
2p6lSAHDiphthine synthase/0.592
2ek4SAHDiphthine synthase/0.591
2e8sSAHDiphthine synthase/0.590
2eeqSAHDiphthine synthase/0.588
2pciSAHDiphthine synthase/0.573
2owfSAHDiphthine synthase/0.563
2ejzSAHDiphthine synthase/0.516
4g7gVFVLanosterol 14-alpha-demethylase/0.464
3zh8C58Protein kinase C iota type2.7.11.130.456
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.454
3ut5LOCTubulin beta chain/0.452
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.450
2xlrFADPutative flavin-containing monooxygenase/0.449
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2p5uNADUDP-glucose 4-epimerase/0.448
3a3gDLZLumazine protein/0.448
1bdlIM1Gag-Pol polyprotein3.4.23.160.446
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
1pjcNADAlanine dehydrogenase/0.445
3tneRITCandidapepsin-13.4.23.240.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.443
1xddAAYIntegrin alpha-L/0.442
2znnS44Peroxisome proliferator-activated receptor alpha/0.442
4q71FADBifunctional protein PutA/0.441
1k8y13PTryptophan synthase alpha chain/0.440
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
2cy0NAPShikimate dehydrogenase (NADP(+))/0.440
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.440
2ifaFMNUncharacterized protein/0.440
2q4bNAPUncharacterized protein At5g02240/0.440
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.440