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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hmySAMModification methylase HhaI2.1.1.37

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2hmySAMModification methylase HhaI2.1.1.371.000
1skmSAHModification methylase HhaI2.1.1.370.602
9mhtSAHModification methylase HhaI2.1.1.370.586
5mhtSAHModification methylase HhaI2.1.1.370.577
7mhtSAHModification methylase HhaI2.1.1.370.574
8mhtSAHModification methylase HhaI2.1.1.370.554
2i9kSAHModification methylase HhaI2.1.1.370.546
2uyhSAHModification methylase HhaI2.1.1.370.542
2z6uSAHModification methylase HhaI2.1.1.370.539
1fjxSAHModification methylase HhaI2.1.1.370.536
10mhSAHModification methylase HhaI2.1.1.370.532
2zcjSAHModification methylase HhaI2.1.1.370.532
1mhtSAHModification methylase HhaI2.1.1.370.524
3mhtSAHModification methylase HhaI2.1.1.370.505
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.505
2c7qSAHModification methylase HhaI2.1.1.370.504
4mhtSAHModification methylase HhaI2.1.1.370.499
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.469
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.468
3qv2SAH5-cytosine DNA methyltransferase/0.460
4h0nSAHDnmt2/0.448
4dkjSAHCytosine-specific methyltransferase/0.440