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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.623
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.597
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.584
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.568
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.564
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.556
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.553
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.539
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3rkb12ZCyclin-dependent kinase 22.7.11.220.471
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.455
4jia1K3Tyrosine-protein kinase JAK2/0.453
2ckeIQUDeath-associated protein kinase 2/0.452
4bcmT7ZCyclin-dependent kinase 22.7.11.220.452
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.448
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.448
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
1jklANPDeath-associated protein kinase 12.7.11.10.446
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3my5RFZCyclin-dependent kinase 22.7.11.220.445
4qnyANPMitogen activated protein kinase, putative/0.444
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441