sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gir | NN3 | Genome polyprotein | 2.7.7.48 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2gir | NN3 | Genome polyprotein | 2.7.7.48 | 1.000 | |
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.509 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.501 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.501 | |
| 4u2s | FDA | Cholesterol oxidase | 1.1.3.6 | 0.501 | |
| 4ju1 | 1NZ | Genome polyprotein | 2.7.7.48 | 0.500 | |
| 3zos | 0LI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.498 | |
| 4jvq | 1ML | Genome polyprotein | 2.7.7.48 | 0.497 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.493 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.492 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.492 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.490 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.490 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.490 | |
| 4pd6 | URI | Nucleoside permease | / | 0.490 | |
| 2bx8 | AZQ | Serum albumin | / | 0.489 | |
| 1fbm | RTL | Cartilage oligomeric matrix protein | / | 0.488 | |
| 3cj3 | SX4 | Genome polyprotein | 2.7.7.48 | 0.488 | |
| 1cc2 | FAD | Cholesterol oxidase | 1.1.3.6 | 0.486 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.485 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.484 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.484 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.484 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.483 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.483 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.482 | |
| 2d3u | CCT | Polyprotein | / | 0.482 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.482 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 1osv | CHC | Bile acid receptor | / | 0.480 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.480 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.480 | |
| 2y02 | Y01 | Beta-1 adrenergic receptor | / | 0.480 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.477 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.477 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.475 | |
| 3ict | COA | Coenzyme A disulfide reductase | / | 0.474 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.474 | |
| 1kgj | FL8 | Transthyretin | / | 0.473 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.473 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.473 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.473 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.472 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.472 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.472 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.472 | |
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.472 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.472 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.472 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.471 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.471 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.470 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.470 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.469 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.469 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.469 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.469 | |
| 3h1j | SMA | Cytochrome b | / | 0.469 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.469 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.469 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.469 | |
| 4oze | 24G | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.469 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.468 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.468 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.468 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 4jtz | 1NW | Genome polyprotein | 2.7.7.48 | 0.468 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.467 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.467 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.466 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.466 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.466 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.466 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.466 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.465 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.465 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.465 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 4aox | FAD | Steroid monooxygenase | / | 0.465 | |
| 4eo8 | 0S3 | Genome polyprotein | 2.7.7.48 | 0.465 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.465 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.464 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.464 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.464 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.464 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.463 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.463 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.462 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.462 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.462 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.462 | |
| 3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.462 | |
| 3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.462 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.462 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.462 | |
| 4l8u | 9AZ | Serum albumin | / | 0.462 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.461 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.461 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.461 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.461 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.461 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.461 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.461 | |
| 3w2c | N15 | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.461 | |
| 4ju2 | 1O0 | Genome polyprotein | 2.7.7.48 | 0.461 | |
| 4o0m | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.461 | |
| 1hdz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.460 | |
| 3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.460 | |
| 4cnk | FAD | L-amino acid oxidase | / | 0.460 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.460 | |
| 4u8j | FDA | UDP-galactopyranose mutase | / | 0.460 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.459 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.459 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 5cms | APR | O-acetyl-ADP-ribose deacetylase | / | 0.459 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.459 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.458 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.458 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.458 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3sh0 | SAX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 3zux | TCH | Transporter | / | 0.458 | |
| 3zuy | TCH | Transporter | / | 0.458 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.457 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 3h65 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.457 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.457 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.457 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.457 | |
| 4oae | CLM | Uncharacterized protein | / | 0.457 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.456 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.456 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.456 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.456 | |
| 3gds | VAL_TYR_TYR_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.456 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.456 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.456 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.456 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.456 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.455 | |
| 1qvn | FRI | Interleukin-2 | / | 0.455 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.455 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.455 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3q8x | UD1 | Toxin zeta | / | 0.455 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.455 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.455 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 5a3c | NAD | SIR2 family protein | / | 0.455 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.454 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1pp9 | SMA | Cytochrome b | / | 0.454 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.454 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.454 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.454 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.454 | |
| 4dlb | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.454 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.454 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.454 | |
| 5a3b | APR | SIR2 family protein | / | 0.454 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.453 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.453 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.453 | |
| 1wc1 | TAT | Adenylate cyclase | / | 0.453 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.453 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 3nfa | CBJ | Gag-Pol polyprotein | / | 0.453 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.453 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.453 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.453 | |
| 4b13 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.453 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 4uya | AGS | Mitogen-activated protein kinase kinase kinase 21 | 2.7.11.25 | 0.453 | |
| 4wq4 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.453 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.453 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.452 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.452 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.452 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4jtw | 1NU | Genome polyprotein | 2.7.7.48 | 0.452 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.452 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.452 | |
| 2gci | MRR | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.451 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.451 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.451 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.451 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.451 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.451 | |
| 3mpa | SB2 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.451 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 5l7d | CLR | Smoothened homolog | / | 0.451 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.450 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 1aqb | RTL | Retinol-binding protein 4 | / | 0.449 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1z1f | STL | Resveratrol synthase | / | 0.449 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.449 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.449 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.449 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.449 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.449 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.449 | |
| 3stx | BKA | Methylketone synthase I | / | 0.449 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4gdd | FAD | UDP-galactopyranose mutase | / | 0.449 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.449 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 4kwh | NAP | Reductase homolog | / | 0.449 | |
| 4qjq | OTR | Lactoperoxidase | / | 0.449 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.448 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.448 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.448 | |
| 2bw7 | ECS | Adenylate cyclase | / | 0.448 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.448 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.448 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.448 | |
| 3phe | C9A | RNA-directed RNA polymerase | / | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.448 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.448 | |
| 4hj2 | LZ6 | Glutathione S-transferase A1 | 2.5.1.18 | 0.448 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 4jty | 1NV | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2x23 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.447 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.447 | |
| 3ute | FAD | UDP-galactopyranose mutase | / | 0.447 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.447 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.447 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.447 | |
| 5ag6 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.446 | |
| 1e7a | PFL | Serum albumin | / | 0.446 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.446 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3liv | E16 | Protease | / | 0.446 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.446 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.446 | |
| 4a2z | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4a32 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.446 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.446 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.446 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.446 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.445 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.445 | |
| 2p2i | 608 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.445 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.445 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.445 | |
| 3eks | CY9 | Actin-5C | / | 0.445 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.445 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.444 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.444 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 2y01 | Y01 | Beta-1 adrenergic receptor | / | 0.444 | |
| 2ycr | HCW | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2zmd | 537 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.444 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.444 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3vhk | BPK | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.444 | |
| 4qpm | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.444 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.444 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.443 | |
| 1gyp | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.443 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.443 | |
| 1wrl | TFP | Troponin C, slow skeletal and cardiac muscles | / | 0.443 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 2hh5 | GNQ | Cathepsin S | 3.4.22.27 | 0.443 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.443 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2qjy | SMA | Cytochrome b | / | 0.443 | |
| 2yim | MC4 | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.443 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.443 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.443 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3sjz | GNP | Translation initiation factor 2 subunit gamma | / | 0.443 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.443 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.443 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.443 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4i5c | C5I | Tyrosine-protein kinase JAK1 | / | 0.443 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.443 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.443 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.442 | |
| 1ppj | SMA | Cytochrome b | / | 0.442 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.442 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.442 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3zxt | ACP | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4cjw | CBJ | Integrase | / | 0.442 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.442 | |
| 4ucn | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.442 | |
| 5kje | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.441 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.441 | |
| 2bxo | OPB | Serum albumin | / | 0.441 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 2ops | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.441 | |
| 3ojl | NAD | Cap5O | / | 0.441 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.441 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.441 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 4gah | 0ET | Acyl-coenzyme A thioesterase THEM4 | 3.1.2.2 | 0.441 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.441 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1wc4 | APC | Adenylate cyclase | / | 0.440 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2jiz | STL | ATP synthase subunit alpha, mitochondrial | / | 0.440 | |
| 2jiz | STL | ATP synthase subunit gamma, mitochondrial | / | 0.440 | |
| 2lf1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.440 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.440 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3m9v | TYD | FAD-dependent oxidoreductase | / | 0.440 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.440 | |
| 4a95 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.440 | |
| 4u0k | 744 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.440 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 |