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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gh5FADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gh5FADGlutathione reductase, mitochondrial1.8.1.71.000
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.575
1graFADGlutathione reductase, mitochondrial1.8.1.70.558
1greFADGlutathione reductase, mitochondrial1.8.1.70.556
1grhFADGlutathione reductase, mitochondrial1.8.1.70.554
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.551
3grsFADGlutathione reductase, mitochondrial1.8.1.70.550
1grgFADGlutathione reductase, mitochondrial1.8.1.70.548
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.540
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.538
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.534
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.532
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.530
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.528
2r9zFADGlutathione amide reductase/0.518
1grbFADGlutathione reductase, mitochondrial1.8.1.70.496
2rabFADGlutathione amide reductase/0.489
3djgFADGlutathione reductase, mitochondrial1.8.1.70.479
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.469
2v6oFADThioredoxin glutathione reductase/0.461
1gerFADGlutathione reductase1.8.1.70.452
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.451
1geuFADGlutathione reductase1.8.1.70.447