sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gfk | VII | Metallo-beta-lactamase L1 type 3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2gfk | VII | Metallo-beta-lactamase L1 type 3 | / | 1.000 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.518 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.514 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.513 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.513 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.513 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.502 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.497 | |
| 2pjl | 047 | Steroid hormone receptor ERR1 | / | 0.496 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.493 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.492 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.490 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.488 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.485 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.484 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.484 | |
| 4kyh | ZST | Lactoylglutathione lyase | 4.4.1.5 | 0.484 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.482 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 3s6a | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.480 | |
| 4khn | XG4 | DNA-directed DNA polymerase | / | 0.480 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.479 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.476 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.475 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.474 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.473 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 4ec3 | REN | Reticuline oxidase | 1.21.3.3 | 0.473 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.472 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.471 | |
| 4k7a | DHT | Androgen receptor | / | 0.471 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.470 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.470 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.470 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.469 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.469 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.469 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.469 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 1qin | GIP | Lactoylglutathione lyase | 4.4.1.5 | 0.468 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.468 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.468 | |
| 3wb4 | 0B3 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.468 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.467 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 4cry | ACO | PanD regulatory factor | / | 0.467 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.467 | |
| 1nd5 | 2BF | Prostatic acid phosphatase | 3.1.3.2 | 0.466 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 1ee1 | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.465 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.465 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.465 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.465 | |
| 1kdm | DHT | Sex hormone-binding globulin | / | 0.464 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.464 | |
| 1lke | DOG | Bilin-binding protein | / | 0.464 | |
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.464 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.464 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.464 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.464 | |
| 2wzm | NA7 | Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 | / | 0.464 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.464 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.464 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.463 | |
| 1t76 | DHT | Androgen receptor | / | 0.463 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.463 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.463 | |
| 1p4r | 354 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.462 | |
| 2mm3 | GCH | Gastrotropin | / | 0.462 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3p9t | TCL | Repressor | / | 0.462 | |
| 4kyk | IMN | Lactoylglutathione lyase | 4.4.1.5 | 0.462 | |
| 1srh | MOB | Streptavidin | / | 0.461 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.461 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.461 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.461 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.460 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.460 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.460 | |
| 3znr | NU9 | Histone deacetylase 7 | 3.5.1.98 | 0.460 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.460 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.459 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 3e9s | TTT | Replicase polyprotein 1ab | 3.4.22 | 0.459 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.459 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.459 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.459 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.458 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.458 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ltz | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.457 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.456 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.456 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1xj7 | DHT | Androgen receptor | / | 0.455 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.455 | |
| 2be2 | R22 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.455 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.455 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.455 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.455 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.454 | |
| 3ahe | THD | Probable phosphoketolase | / | 0.454 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4p5f | AR6 | Inosine-uridine nucleoside N-ribohydrolase | / | 0.454 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.454 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.453 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.453 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.453 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.453 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4dls | GNP | GTPase HRas | / | 0.453 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 4l65 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 | 0.453 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.453 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.452 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.452 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.452 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2hai | PFI | Polyprotein | / | 0.452 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3kro | IPE | Geranyl diphosphate synthase large subunit | / | 0.452 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.452 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.452 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.452 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.451 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 1yy4 | 4NA | Estrogen receptor beta | / | 0.451 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.451 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.451 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.451 | |
| 3m34 | TPP | Transketolase | / | 0.451 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.451 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.451 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.450 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.450 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.450 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.450 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.450 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2pix | DHT | Androgen receptor | / | 0.450 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.450 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4l2z | S7M | S-adenosylmethionine synthase | / | 0.450 | |
| 4yao | 2AM | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 4zas | TYD | CalS13 | / | 0.450 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.450 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2ght | SER_PRO_THR_PRO_SEP | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | 3.1.3.16 | 0.449 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2piw | DHT | Androgen receptor | / | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.449 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4lwx | MU2 | Ribosome inactivating protein | / | 0.449 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.448 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1l2i | ETC | Estrogen receptor | / | 0.448 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.448 | |
| 1uio | HPR | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.448 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.448 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 1rt1 | MKC | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1w1w | AGS | Structural maintenance of chromosomes protein 1 | / | 0.447 | |
| 2am9 | TES | Androgen receptor | / | 0.447 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 2j5s | KTA | Alr4455 protein | / | 0.447 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.447 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.447 | |
| 3c1o | NAP | Eugenol synthase | / | 0.447 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.447 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.447 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.447 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.447 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.447 | |
| 5d8u | 0N8 | Polymerase acidic protein | / | 0.447 | |
| 1bye | ATA | Glutathione S-transferase 1 | 2.5.1.18 | 0.446 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.446 | |
| 1pxg | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 1tdc | UMP | Thymidylate synthase | / | 0.446 | |
| 1tvu | CB3 | Thymidylate synthase | / | 0.446 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.446 | |
| 2qpy | DHT | Androgen receptor | / | 0.446 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3rc7 | TLO | Sugar 3-ketoreductase | / | 0.446 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.446 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.446 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.446 | |
| 1a50 | FIP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1b7t | ADP | Myosin heavy chain, striated muscle | / | 0.445 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.445 | |
| 2clm | F6F | Tryptophan synthase alpha chain | / | 0.445 | |
| 2dy9 | ADP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.445 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.445 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2pot | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 2w0h | NDP | Trypanothione reductase | / | 0.445 | |
| 2ylp | TES | Androgen receptor | / | 0.445 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.445 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.445 | |
| 4a39 | GEM | Uncharacterized protein | / | 0.445 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4dlw | GNP | GTPase HRas | / | 0.445 | |
| 4h6p | FMN | Chromate reductase | / | 0.445 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.445 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.445 | |
| 4ktt | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.445 | |
| 4o7n | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.445 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.444 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.444 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.444 | |
| 1q63 | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.444 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1yun | ATP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.444 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.444 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bns | MST | Reaction center protein L chain | / | 0.444 | |
| 2opb | F21 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.444 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.444 | |
| 3aq0 | ISY | Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial | 2.5.1.85 | 0.444 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.444 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.444 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.444 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2f8p | CEI | Obelin | / | 0.443 | |
| 2pit | DHT | Androgen receptor | / | 0.443 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.443 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3ert | OHT | Estrogen receptor | / | 0.443 | |
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 0.443 | |
| 3n39 | FMN | Protein NrdI | / | 0.443 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3tfp | 03L | Dehydrosqualene synthase | / | 0.443 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.443 | |
| 4dne | DTB | Streptavidin | / | 0.443 | |
| 4fj0 | HHF | 17beta-hydroxysteroid dehydrogenase | / | 0.443 | |
| 4fsa | 0V3 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.443 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1p16 | GTP | mRNA-capping enzyme subunit alpha | 2.7.7.50 | 0.442 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1syn | F89 | Thymidylate synthase | / | 0.442 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2zf4 | PPY | Uncharacterized protein | / | 0.442 | |
| 3axs | SFG | tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase | / | 0.442 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.442 | |
| 3htj | ET | EbrA repressor | / | 0.442 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3roe | THM | NAD(P)H-hydrate epimerase | 5.1.99.6 | 0.442 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.442 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4xt8 | TMQ | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.442 | |
| 4zo3 | C6L | Acylhomoserine lactonase | / | 0.442 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.441 | |
| 1gs4 | ZK5 | Androgen receptor | / | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1qlt | FAD | Vanillyl-alcohol oxidase | 1.1.3.38 | 0.441 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.441 | |
| 1s4e | ADP | Galactokinase | / | 0.441 | |
| 1wop | FFO | Aminomethyltransferase | / | 0.441 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.441 | |
| 2isj | FMN | 5,6-dimethylbenzimidazole synthase | 1.13.11.79 | 0.441 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3dqw | AGS | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.441 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.441 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3nju | ANN | Acidic phospholipase A2 3 | 3.1.1.4 | 0.441 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.441 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.441 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.441 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4isf | 1FX | Glucokinase | 2.7.1.2 | 0.441 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.441 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.440 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 3fgo | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 3ozs | OZS | Catechol O-methyltransferase | 2.1.1.6 | 0.440 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.440 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.440 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.440 |