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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gdo12CSerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gdo12CSerine/threonine-protein kinase Chk12.7.11.11.000
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.519
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.518
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.511
2vv9IM9Cyclin-dependent kinase 22.7.11.220.484
1fvv107Cyclin-dependent kinase 22.7.11.220.482
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.481
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.479
2uzbC75Cyclin-dependent kinase 22.7.11.220.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.477
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.477
3nynSGVG protein-coupled receptor kinase 62.7.11.160.475
4y93746Tyrosine-protein kinase/0.473
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.472
1pxmCK5Cyclin-dependent kinase 22.7.11.220.471
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.470
2w17I19Cyclin-dependent kinase 22.7.11.220.470
3qxpX64Cyclin-dependent kinase 22.7.11.220.470
3s1h56ZCyclin-dependent kinase 22.7.11.220.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.469
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.468
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.468
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.467
3r8lZ30Cyclin-dependent kinase 22.7.11.220.467
3at4CCKCasein kinase II subunit alpha2.7.11.10.466
3eb0DRKUncharacterized protein/0.466
3nux3NVCyclin-dependent kinase 62.7.11.220.465
3rak03ZCyclin-dependent kinase 22.7.11.220.465
3gu83GUDeath-associated protein kinase 12.7.11.10.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.463
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.463
4aqc88ATyrosine-protein kinase JAK2/0.463
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.463
4jboWPHAurora kinase A2.7.11.10.463
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.462
5av2KMPDeath-associated protein kinase 12.7.11.10.462
2fvdLIACyclin-dependent kinase 22.7.11.220.460
4btjATPTau-tubulin kinase 12.7.11.10.460
4f081RSTyrosine-protein kinase JAK2/0.460
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
4bcmT7ZCyclin-dependent kinase 22.7.11.220.458
2wouZZFTGF-beta receptor type-12.7.11.300.457
4bgg844Activin receptor type-12.7.11.300.457
4ehzJAKTyrosine-protein kinase JAK1/0.457
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.456
4hvi19STyrosine-protein kinase JAK32.7.10.20.456
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.455
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.455
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.455
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.454
4hge15VTyrosine-protein kinase JAK2/0.454
2b52D42Cyclin-dependent kinase 22.7.11.220.453
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.453
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
4i5cC5ITyrosine-protein kinase JAK1/0.452
1pxoCK7Cyclin-dependent kinase 22.7.11.220.451
4e6d0NUTyrosine-protein kinase JAK2/0.451
5e8ySTUTGF-beta receptor type-22.7.11.300.451
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
3my5RFZCyclin-dependent kinase 22.7.11.220.450
3rkb12ZCyclin-dependent kinase 22.7.11.220.450
4grb0XGCasein kinase II subunit alpha2.7.11.10.450
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
2w05FRTCyclin-dependent kinase 22.7.11.220.449
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
3sw719KCyclin-dependent kinase 22.7.11.220.449
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.449
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.448
2uzdC85Cyclin-dependent kinase 22.7.11.220.448
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.448
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
2btsU32Cyclin-dependent kinase 22.7.11.220.447
2vu3LZECyclin-dependent kinase 22.7.11.220.447
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.447
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.447
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.446
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.446
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.446
4j95ACPFibroblast growth factor receptor 2/0.446
2yaaATPDeath-associated protein kinase 2/0.445
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.445
3u4uLNHCasein kinase II subunit alpha2.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4fkv61KCyclin-dependent kinase 22.7.11.220.445
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.443
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.443
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.443
5cvfATPCasein kinase II subunit alpha2.7.11.10.443
1aq1STUCyclin-dependent kinase 22.7.11.220.442
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.442
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.442
4nk92K5Fibroblast growth factor receptor 1/0.442
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.441
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.441
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
3pe2E1BCasein kinase II subunit alpha2.7.11.10.441
4dymIYZActivin receptor type-12.7.11.300.441
5dr9SKEAurora kinase A2.7.11.10.441
1om1IQACasein kinase II subunit alpha2.7.11.10.440
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.440
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fkt48KCyclin-dependent kinase 22.7.11.220.440
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.440
4j99ACPFibroblast growth factor receptor 2/0.440
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.440