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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gcpGSPRho-related GTP-binding protein RhoC

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2gcpGSPRho-related GTP-binding protein RhoC/1.000
1cxzGSPTransforming protein RhoA/0.632
1kmqGNPTransforming protein RhoA/0.631
1m7bGTPRho-related GTP-binding protein RhoE/0.585
3kz1GSPTransforming protein RhoA/0.576
1s1cGNPTransforming protein RhoA/0.556
4xoiGTPTransforming protein RhoA/0.552
4js0GNPCell division control protein 42 homolog/0.534
1z2cGNPRho-related GTP-binding protein RhoC/0.533
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.533
5hpyGDPTransforming protein RhoA/0.531
1a2bGSPTransforming protein RhoA/0.527
3lbnGNPGTPase HRas/0.526
3eg5GNPCell division control protein 42 homolog/0.524
2gilGTPRas-related protein Rab-6A/0.523
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.521
3oiuGNPGTPase HRas/0.515
1xtrGNPGTP-binding protein Rheb/0.506
3a58GNPGTP-binding protein RHO1/0.506
1zc4GNPRas-related protein Ral-A/0.504
4mitGTPRho-related protein racC/0.504
1g17GNPRas-related protein SEC4/0.502
1ow3GDPTransforming protein RhoA/0.500
1t91GTPRas-related protein Rab-7a/0.499
1zc3GNPRas-related protein Ral-A/0.499
3i3sGNPGTPase HRas/0.499
1xtsGTPGTP-binding protein Rheb/0.493
3v4fGNPGTPase HRas/0.491
3oivGNPGTPase HRas/0.488
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.482
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.482
4kvgGTPRas-related protein Rap-1A/0.481
3kucGDPRas-related protein Rap-1A/0.478
1yhnGTPRas-related protein Rab-7a/0.476
1gwnGTPRho-related GTP-binding protein RhoE/0.472
3th5GNPRas-related C3 botulinum toxin substrate 1/0.472
5b2zGNPGTPase HRas/0.469
3e5hGNPRas-related protein Rab-28/0.466
3rs7GNPGTPase HRas/0.466
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.466
4nyjGNPGTPase HRas/0.466
4qxaGTPRas-related protein Rab-9A/0.460
3rabGNPRas-related protein Rab-3A/0.459
4dlwGNPGTPase HRas/0.459
4dltGNPGTPase HRas/0.458
3rs5GNPGTPase HRas/0.457
1yzqGNPRas-related protein Rab-6A/0.455
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.455
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.453
1z0aGDPRas-related protein Rab-2A/0.452
5dhaGNPGTP-binding nuclear protein Ran/0.451
2zetGTPRas-related protein Rab-27B/0.446
4lhwGNPRas-related protein Rab-8A/0.442
4nyiGNPGTPase HRas/0.440