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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g28TDKPyruvate dehydrogenase E1 component1.2.4.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2g28TDKPyruvate dehydrogenase E1 component1.2.4.11.000
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.636
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.552
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.529
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.498
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.451