sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fzb | TOL | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.718 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.638 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.582 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.570 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.570 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.566 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.556 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.517 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.505 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.504 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.502 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.495 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.494 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.493 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 4phl | PIL | Phosphodiesterase | / | 0.490 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.489 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.487 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.486 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.486 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.484 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.482 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 1lke | DOG | Bilin-binding protein | / | 0.480 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.480 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.477 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.476 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.476 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.475 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.475 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.474 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.474 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.474 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.473 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.471 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 2hzq | STR | Apolipoprotein D | / | 0.468 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.468 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.468 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.467 | |
| 1u08 | PLP | Methionine aminotransferase | / | 0.466 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.466 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.466 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.464 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.464 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.463 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.462 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.462 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.461 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.460 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.459 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.459 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.459 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.459 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.458 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.458 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.457 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.457 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.457 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.457 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.457 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.457 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.457 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.456 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.456 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.456 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.456 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.456 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.455 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.455 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.454 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.454 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1rxj | BNI | Streptavidin | / | 0.453 | |
| 1uhj | CZB | Aequorin-2 | / | 0.453 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.453 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.453 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.453 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.453 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.453 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.453 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.452 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.452 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.452 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.451 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.451 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.451 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.451 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.450 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1s36 | CEI | Obelin | / | 0.449 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.449 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.449 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.449 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.448 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1lqa | NDP | Protein tas | / | 0.448 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.448 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.447 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.447 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3w5u | FAD | Ferredoxin | / | 0.447 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4kxj | P34 | Nucleoprotein | / | 0.447 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.446 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.445 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2xvw | 9NR | Serum albumin | / | 0.445 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.445 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.444 | |
| 3pn1 | IVH | DNA ligase | / | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.443 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.443 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.443 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.443 | |
| 4mm4 | 8PR | Na(+):neurotransmitter symporter (Snf family) | / | 0.443 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1syn | F89 | Thymidylate synthase | / | 0.442 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.442 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.442 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.442 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.442 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4s1h | ADP | Pyridoxal kinase, putative | / | 0.442 | |
| 1e6z | NGO | Chitinase | / | 0.441 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.441 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.441 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.441 | |
| 4yfy | 1YJ | VioF | / | 0.441 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.440 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.440 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.440 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.440 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.440 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.440 | |
| 4a1o | AMZ | Bifunctional purine biosynthesis protein PurH | 2.1.2.3 | 0.440 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.440 |