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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2foiJPAEnoyl-acyl carrier reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2foiJPAEnoyl-acyl carrier reductase/1.000
1nhgTCLEnoyl-ACP reductase/0.685
1nhwTCCEnoyl-ACP reductase/0.667
1zxlJP1Enoyl-ACP reductase/0.636
3lt2FT3Enoyl-ACP reductase/0.588
2o2yTCLEnoyl-ACP reductase/0.576
2op07PCEnoyl-ACP reductase/0.570
1zsnTN2Enoyl-ACP reductase/0.569
3am4FT1Enoyl-ACP reductase/0.569
3f4bTCLEnoyl-acyl carrier protein reductase/0.569
3am3TCLEnoyl-ACP reductase/0.567
1uh5TCLEnoyl-ACP reductase/0.557
1zw1TN5Enoyl-ACP reductase/0.554
3lsyFT0Enoyl-ACP reductase/0.545
1nnuTCTEnoyl-ACP reductase/0.534
2nq8ZIDEnoyl-ACP reductase/0.525
3am5TCLEnoyl-ACP reductase/0.525
4igeCHJEnoyl-acyl carrier reductase/0.516
3lt0FT1Enoyl-ACP reductase/0.515
2o2sTCLEnoyl-acyl carrier reductase/0.509
3lt1FT2Enoyl-ACP reductase/0.509
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4lb2DM5Serum albumin/0.470
4ixc1JDGlucokinase2.7.1.20.466
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
2o4rVD5Vitamin D3 receptor/0.463
5idwNAPShort-chain dehydrogenase/reductase SDR/0.462
4g2h0VQVitamin D3 receptor A/0.461
3ijdC2FMethylenetetrahydrofolate reductase/0.459
4cf7ADPAdenylate kinase/0.459
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
5bylGCPBifunctional AAC/APH2.3.10.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.456
1kceCB3Thymidylate synthase/0.455
1hkuNADC-terminal-binding protein 11.1.10.454
3vtbTKAVitamin D3 receptor/0.454
1rkhVD2Vitamin D3 receptor/0.452
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
1vrwNAIEnoyl-ACP reductase/0.450
3zoiM2WIsopenicillin N synthase1.21.3.10.450
4fhh0U3Vitamin D3 receptor A/0.450
3h1vTK1Glucokinase2.7.1.20.448
4bqg50QHeat shock protein HSP 90-alpha/0.448
1y4lSVRBasic phospholipase A2 homolog 2/0.447
4g1z0VPVitamin D3 receptor A/0.447
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
2o4jVD4Vitamin D3 receptor/0.445
2pswCOAN-alpha-acetyltransferase 50/0.445
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
3znpFADD-amino-acid oxidase1.4.3.30.445
1powFADPyruvate oxidase1.2.3.30.444
1snyNAPLD36273p/0.444
3nj8NJ8Enoyl-acyl carrier reductase/0.444
3nx4NAPPutative oxidoreductase/0.444
1dr3HBIDihydrofolate reductase1.5.1.30.443
2cnsACORibosomal-protein-alanine acetyltransferase/0.443
3v9v21LPeroxisome proliferator-activated receptor gamma/0.443
5kcpNAJAlcohol dehydrogenase E chain1.1.1.10.443
1txiTX5Vitamin D3 receptor/0.442
1dkfBMSRetinoic acid receptor alpha/0.441
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.441
2bbqPFGThymidylate synthase/0.441
1db1VDXVitamin D3 receptor/0.440
1zeoC01Peroxisome proliferator-activated receptor gamma/0.440
2dhfDZFDihydrofolate reductase1.5.1.30.440
3vt8YI3Vitamin D3 receptor/0.440
4xzmNAPAldo-keto reductase family 1 member B101.1.10.440