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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fj1CTCTetracycline repressor protein class D

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2fj1CTCTetracycline repressor protein class D/1.000
2vkeTACTetracycline repressor protein class D/0.626
2xpuTDCTetracycline repressor protein class D/0.622
2tctCTCTetracycline repressor protein class D/0.597
4b3aTACTetracycline repressor protein class D/0.597
4auxXTCTetracycline repressor protein class D/0.587
2xb5I7TTetracycline repressor protein class D/0.576
2o7oDXTTetracycline repressor protein class D/0.572
2xpvMIYTetracycline repressor protein class D/0.567
2xpwOTCTetracycline repressor protein class D/0.567
2xrlDXTTetracycline repressor protein class D/0.567
2x9dITCTetracycline repressor protein class D/0.565
4v2gITCTetracycline repressor protein class D/0.564
1orkATCTetracycline repressor protein class D/0.555
4d7mTDCTetracycline repressor protein class D/0.551
5fklTDCTetracycline repressor protein class D/0.546
5fkmTDCTetracycline repressor protein class D/0.538
2trtTACTetracycline repressor protein class D/0.535
4b1rITCTetracycline repressor protein class D/0.532
2x6o2TCTetracycline repressor protein class D/0.508
2vkvTDCTetracycline repressor protein class D/0.499
4abzT1CTetracycline repressor protein class D/0.487
2vprTDCTetracycline repressor protein class H/0.478
2fy4COACholine O-acetyltransferase2.3.1.60.461
1w6hTITPlasmepsin-23.4.23.390.459
5fkoTDCTetracycline repressor protein class D/0.458
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.456
4ambDUDPutative glycosyl transferase/0.449
1xe55FEPlasmepsin-23.4.23.390.447
2xviFADPutative flavin-containing monooxygenase/0.447
2qbuSAHPrecorrin-2 methyltransferase/0.446
5fknTDCTetracycline repressor protein class D/0.445
3ig6438Urokinase-type plasminogen activator3.4.21.730.443
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441