sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2fcr | FMN | Flavodoxin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2fcr | FMN | Flavodoxin | / | 1.000 | |
| 4fx2 | FMN | Flavodoxin | / | 0.578 | |
| 3f6r | FMN | Flavodoxin | / | 0.576 | |
| 1aku | FMN | Flavodoxin | / | 0.566 | |
| 1fx1 | FMN | Flavodoxin | / | 0.560 | |
| 1ofv | FMN | Flavodoxin | / | 0.559 | |
| 1wsb | FMN | Flavodoxin | / | 0.558 | |
| 1akw | FMN | Flavodoxin | / | 0.556 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.555 | |
| 1j9g | FMN | Flavodoxin | / | 0.550 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.545 | |
| 1azl | FMN | Flavodoxin | / | 0.537 | |
| 1c7f | FMN | Flavodoxin | / | 0.534 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.533 | |
| 1j8q | FMN | Flavodoxin | / | 0.530 | |
| 5fx2 | FMN | Flavodoxin | / | 0.528 | |
| 1bu5 | RBF | Flavodoxin | / | 0.526 | |
| 1czn | FMN | Flavodoxin | / | 0.524 | |
| 3f90 | FMN | Flavodoxin | / | 0.524 | |
| 2fx2 | FMN | Flavodoxin | / | 0.520 | |
| 3kap | FMN | Flavodoxin | / | 0.520 | |
| 5xra | FMN | Cannabinoid receptor 1 | / | 0.520 | |
| 1xyv | FMN | Flavodoxin | / | 0.518 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.514 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.514 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.514 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.514 | |
| 3kaq | FMN | Flavodoxin | / | 0.511 | |
| 5tgz | FMN | Cannabinoid receptor 1 | / | 0.511 | |
| 1ahn | FMN | Flavodoxin 1 | / | 0.505 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.501 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.500 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.496 | |
| 5xr8 | FMN | Cannabinoid receptor 1 | / | 0.496 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.495 | |
| 1gaw | FAD | Ferredoxin | / | 0.494 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.493 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.492 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.492 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.492 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.492 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.492 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.491 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.491 | |
| 1fue | FMN | Flavodoxin | / | 0.490 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.490 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.489 | |
| 3n3a | FMN | Protein NrdI | / | 0.489 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.489 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.489 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.489 | |
| 1ecb | 5GP | Amidophosphoribosyltransferase | / | 0.488 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.488 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.487 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.487 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.486 | |
| 3n39 | FMN | Protein NrdI | / | 0.486 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.485 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.485 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.484 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.483 | |
| 1xyy | FMN | Flavodoxin | / | 0.483 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.483 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.482 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.482 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.481 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.480 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.480 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.480 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.479 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.479 | |
| 3n3b | FMN | Protein NrdI | / | 0.479 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.479 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.478 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.478 | |
| 4h2d | FMN | NADPH-dependent diflavin oxidoreductase 1 | / | 0.478 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.477 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.477 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.476 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.476 | |
| 2v5v | FMN | Flavodoxin | / | 0.476 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.476 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.476 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.475 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.475 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.475 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.475 | |
| 1til | ATP | Anti-sigma F factor | / | 0.475 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.475 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.474 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.474 | |
| 2r5n | TPP | Transketolase 1 | / | 0.474 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.474 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.473 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.473 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.473 | |
| 4rxq | DUT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.473 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.472 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.472 | |
| 2ejz | SAH | Diphthine synthase | / | 0.472 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.472 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.472 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.472 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.472 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.472 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.471 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.471 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.471 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.471 | |
| 4dy4 | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.471 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.470 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.470 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.470 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.470 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.470 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.470 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.470 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.470 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.470 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.470 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.469 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.469 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.469 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.469 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.469 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.469 | |
| 4oxx | FMN | Cindoxin | / | 0.469 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.468 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 1yob | FMN | Flavodoxin 2 | / | 0.468 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.468 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.468 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.468 | |
| 1l0o | ADP | Anti-sigma F factor | / | 0.467 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.467 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.467 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.467 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.467 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.467 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.467 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.467 | |
| 1lke | DOG | Bilin-binding protein | / | 0.466 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.466 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.466 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 1ykg | FMN | Sulfite reductase [NADPH] flavoprotein alpha-component | / | 0.466 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.466 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.466 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.466 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.466 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.465 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.465 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.465 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.465 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.465 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.465 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.465 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.464 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.464 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.464 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.464 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.464 | |
| 1zdf | UPG | Glycogenin-1 | 2.4.1.186 | 0.464 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.464 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.464 | |
| 3esy | FMN | Flavodoxin | / | 0.464 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.464 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.464 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.464 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.463 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.463 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.463 | |
| 2x90 | EAL | Angiotensin-converting enzyme | 3.4.15.1 | 0.463 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.463 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.463 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.463 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.463 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.463 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.463 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.463 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.463 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.463 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2owf | SAH | Diphthine synthase | / | 0.462 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.462 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.462 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.462 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.462 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.462 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.462 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.462 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.461 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1njj | ORX | Ornithine decarboxylase | / | 0.461 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.461 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2pda | TPP | Pyruvate synthase | / | 0.461 | |
| 2qcx | PF1 | Aminopyrimidine aminohydrolase | / | 0.461 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.461 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.461 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.461 | |
| 3rga | ILD | Epoxide hydrolase LasB | 5.5.1 | 0.461 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.461 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.461 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 5c4c | UPG | Histo-blood group ABO system transferase | / | 0.461 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.460 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.460 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.460 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.460 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.460 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.460 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.460 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.460 | |
| 1lcw | SHM | Streptavidin | / | 0.459 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.459 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.459 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.459 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 3eku | CY9 | Actin-5C | / | 0.459 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.459 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.459 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.458 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.458 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.458 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.458 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.458 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.458 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.458 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.458 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.458 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.458 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.458 | |
| 3rdq | DTB | Streptavidin | / | 0.458 | |
| 3v2u | ATP | Protein GAL3 | / | 0.458 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.458 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.458 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.457 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.457 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.457 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.457 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1qd1 | FON | Formimidoyltransferase-cyclodeaminase | 2.1.2.5 | 0.457 | |
| 2fto | TMP | Thymidylate synthase | / | 0.457 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.457 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.457 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.457 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.456 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 2vut | NAD | Nitrogen metabolite repression protein nmrA | / | 0.456 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.456 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.456 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.456 | |
| 3zgl | 10E | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.456 | |
| 4bqw | QNM | Egl nine homolog 1 | / | 0.456 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.456 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.455 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.455 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.455 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.455 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.455 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.455 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.455 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.455 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.455 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3klb | FMN | Uncharacterized protein | / | 0.455 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.455 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.455 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.455 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4dne | DTB | Streptavidin | / | 0.455 | |
| 4ixt | 1H1 | Halohydrin dehalogenase | / | 0.455 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.455 | |
| 1cl2 | PPG | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.454 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.454 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.454 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2ix5 | CAA | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.454 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.454 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.454 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 4ap3 | NAP | Steroid monooxygenase | / | 0.454 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.454 | |
| 4kxj | P34 | Nucleoprotein | / | 0.454 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.454 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.454 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.453 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.453 | |
| 1ri4 | SAM | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.453 | |
| 1sre | HAB | Streptavidin | / | 0.453 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.453 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.453 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.453 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.453 | |
| 2xw1 | 9NV | Serum albumin | / | 0.453 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.453 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.453 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.453 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.453 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.453 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.453 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.453 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.453 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.453 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 1gaq | FAD | Ferredoxin | / | 0.452 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.452 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.452 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.452 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.452 | |
| 1srh | MOB | Streptavidin | / | 0.452 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.452 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.452 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.452 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.452 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.452 | |
| 2r4u | ADP | Glycogen synthase | 2.4.1.21 | 0.452 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.452 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.452 | |
| 2zry | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.452 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.452 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.452 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.452 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 1rl3 | PCG | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.451 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.451 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.451 | |
| 3eks | CY9 | Actin-5C | / | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.451 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.451 | |
| 4l9q | 9TP | Serum albumin | / | 0.451 | |
| 4tla | ADP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.451 | |
| 4y1b | NAP | AntE | / | 0.451 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.450 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.450 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.450 | |
| 1s17 | GNR | Peptide deformylase | / | 0.450 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.450 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.450 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.450 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.450 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.450 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.450 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.450 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.450 | |
| 4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
| 4h4e | 10G | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.450 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4tl8 | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.450 | |
| 4wxf | PLG | Serine hydroxymethyltransferase | / | 0.450 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.450 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.449 | |
| 1oo6 | SN2 | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.449 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.449 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.449 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2oke | DUP | DUTP pyrophosphatase | / | 0.449 | |
| 2r8p | T6F | Transketolase 1 | / | 0.449 | |
| 2rtf | BTN | Streptavidin | / | 0.449 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.449 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3v49 | PK0 | Androgen receptor | / | 0.449 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.449 | |
| 4ijr | NDP | D-arabinose dehydrogenase [NAD(P)+] heavy chain | 1.1.1.117 | 0.449 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.449 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.449 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.449 | |
| 4to0 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.449 | |
| 4v0s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.449 | |
| 5dp2 | NAP | CurF | / | 0.449 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.448 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.448 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.448 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.448 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.448 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.448 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.448 | |
| 2o4g | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.448 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.448 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.448 | |
| 3w5u | FAD | Ferredoxin | / | 0.448 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4bmp | FMN | Protein NrdI | / | 0.448 | |
| 4ccq | NAP | Thioredoxin reductase | / | 0.448 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.448 | |
| 1ao0 | 5GP | Amidophosphoribosyltransferase | / | 0.447 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.447 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.447 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.447 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.447 | |
| 2wow | NDP | Trypanothione reductase | / | 0.447 | |
| 2zrf | DTP | Protein RecA | / | 0.447 | |
| 3b9l | AZZ | Serum albumin | / | 0.447 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.447 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3nhy | A7B | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.447 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.447 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.447 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.447 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.446 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1zky | 689 | Estrogen receptor | / | 0.446 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.446 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2dxw | SAH | Diphthine synthase | / | 0.446 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.446 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.446 | |
| 2g1m | 4HG | Egl nine homolog 1 | / | 0.446 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.446 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.446 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.446 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.446 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.446 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.446 | |
| 4h4c | 10D | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.446 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.446 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.446 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.446 | |
| 4yfy | 1YJ | VioF | / | 0.446 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1mk5 | BTN | Streptavidin | / | 0.445 | |
| 1qji | PKF | Astacin | / | 0.445 | |
| 1sbr | VIB | Putative HMP/thiamine-binding protein YkoF | / | 0.445 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.445 | |
| 2e8h | SAH | Diphthine synthase | / | 0.445 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.445 | |
| 2vf7 | ADP | UvrABC system protein A | / | 0.445 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.445 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.445 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.445 | |
| 3bnk | FMN | Flavoredoxin | / | 0.445 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.445 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.445 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.445 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.445 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4l7v | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.445 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.445 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 5alu | HD2 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 5gcn | COA | HAT A1 | / | 0.445 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.444 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.444 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.444 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.444 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.444 | |
| 4hxy | NDP | Plm1 | / | 0.444 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.443 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2jgs | BTN | Avidin | / | 0.443 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.443 | |
| 2uz2 | BTN | Avd protein | / | 0.443 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.443 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.443 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.443 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.443 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.443 | |
| 5f12 | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.443 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1e1l | NAP | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.442 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.442 | |
| 1g28 | FMN | PHY3 | / | 0.442 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.442 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.442 | |
| 1wng | SAH | Diphthine synthase | / | 0.442 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.442 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.442 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.442 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2dek | SAH | Diphthine synthase | / | 0.442 | |
| 2g0l | FLN | Neocarzinostatin | / | 0.442 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.442 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.442 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.442 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.442 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.442 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.442 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3ry2 | BTN | Streptavidin | / | 0.442 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.442 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.442 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.442 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.442 | |
| 4j7h | TRH | PCZA361.3 | / | 0.442 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.442 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.441 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.441 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.441 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.441 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.441 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.441 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.441 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2x96 | RX3 | Angiotensin-converting enzyme | 3.4.15.1 | 0.441 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.441 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3wt0 | ATP | Cell division protein FtsA | / | 0.441 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.441 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.441 | |
| 5fit | AP2 | Bis(5'-adenosyl)-triphosphatase | 3.6.1.29 | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.441 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.440 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.440 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.440 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1j0d | 5PA | 1-aminocyclopropane-1-carboxylate deaminase | 3.5.99.7 | 0.440 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kdk | DHT | Sex hormone-binding globulin | / | 0.440 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.440 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.440 | |
| 2bbf | 344 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 2clm | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.440 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.440 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.440 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4to6 | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 |