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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fa3ACOHydroxymethylglutaryl-CoA synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2fa3ACOHydroxymethylglutaryl-CoA synthase/1.000
1txtCAAHMG-CoA synthase/0.559
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.556
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.552
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.511
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.510
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.504
1yslCOAHydroxymethylglutaryl-CoA synthase2.3.3.100.503
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.502
2rlcCHDCholoylglycine hydrolase3.5.1.240.500
1x2hLPALipoate-protein ligase A6.3.1.200.499
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.498
4nbwNADShort-chain dehydrogenase/reductase SDR/0.496
3fr5I4AFatty acid-binding protein, adipocyte/0.495
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.493
1tysTMPThymidylate synthase/0.492
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.491
1rx8NAPDihydrofolate reductase1.5.1.30.490
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.490
4l1xNAPAldo-keto reductase family 1 member C2/0.490
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.490
4u7wNDPMxaA/0.489
1tysDHFThymidylate synthase/0.488
3q9bB3NAcetylpolyamine amidohydrolase/0.488
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.486
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.485
3eksCY9Actin-5C/0.485
4xq9NADHomospermidine synthase2.5.1.440.485
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.485
1toiHCIAspartate aminotransferase2.6.1.10.484
4bfzZVZPantothenate kinase2.7.1.330.484
3phiNDPShikimate dehydrogenase (NADP(+))/0.482
1ddsMTXDihydrofolate reductase1.5.1.30.481
1z7yAA5Cysteine synthase 12.5.1.470.481
2ek2SAHDiphthine synthase/0.481
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.481
4jtqNAPAldo-keto reductase family 1 member C2/0.481
1tojHCIAspartate aminotransferase2.6.1.10.480
2bxmIMNSerum albumin/0.480
2eh5SAHDiphthine synthase/0.480
2vbpVB1Isopenicillin N synthase1.21.3.10.480
4dptAGSMevalonate diphosphate decarboxylase/0.480
4rww2BALmo2692 protein/0.480
1ra3MTXDihydrofolate reductase1.5.1.30.479
1u2yGOXPancreatic alpha-amylase/0.479
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.479
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.479
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.478
2emrSAHDiphthine synthase/0.477
2z4sADPChromosomal replication initiator protein DnaA/0.477
3otwCOAPhosphopantetheine adenylyltransferase/0.477
2dv7SAHDiphthine synthase/0.476
1b2lNDCAlcohol dehydrogenase1.1.1.10.475
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.475
2w6zL21Biotin carboxylase6.3.4.140.475
3ig6438Urokinase-type plasminogen activator3.4.21.730.475
3in6FMNUncharacterized protein/0.475
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.475
4tvbNADHomospermidine synthase2.5.1.440.475
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.475
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.474
2rqfJH3Hemolymph juvenile hormone binding protein/0.474
3fznD7KBenzoylformate decarboxylase4.1.1.70.474
3hlwCE3Beta-lactamase/0.474
4k6fNAPPutative Acetoacetyl-CoA reductase/0.474
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.472
2b53D23Cyclin-dependent kinase 22.7.11.220.472
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.472
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.472
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.472
1g63FMNEpidermin decarboxylase4.1.10.471
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
3hk1B64Fatty acid-binding protein, adipocyte/0.471
4oztP1AEcdysone receptor, putative/0.471
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.470
1nzfUPGDNA beta-glucosyltransferase/0.470
1pjcNADAlanine dehydrogenase/0.470
2emuSAHDiphthine synthase/0.470
3fhxPXLPyridoxal kinase2.7.1.350.470
4twnB96Ephrin type-A receptor 32.7.10.10.470
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.470
4xqcNADHomospermidine synthase2.5.1.440.470
1bwlFMNNADPH dehydrogenase 11.6.99.10.469
2wi72KLHeat shock protein HSP 90-alpha/0.469
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.469
3kb6NADD-lactate dehydrogenase/0.469
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.469
1g1aNADdTDP-glucose 4,6-dehydratase/0.468
1yqzCOACoenzyme A disulfide reductase/0.468
1zgi382Prothrombin3.4.21.50.468
3fhxPLPPyridoxal kinase2.7.1.350.468
3fp0FP015-O-acetyltransferase/0.468
4an4DUDPutative glycosyl transferase/0.468
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.468
5fsyAR6Uncharacterized protein/0.468
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.467
2he5NDPAldo-keto reductase family 1 member C211.1.10.467
2v2zADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.467
3bgxMEFThymidylate synthase/0.467
3wqmB29Diterpene synthase3.1.7.80.467
4e2dFMNDehydrogenase/0.467
4m6jNDPDihydrofolate reductase1.5.1.30.467
2gjnFMNNitronate monooxygenase1.13.12.160.466
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.466
2zbaZBATrichothecene 3-O-acetyltransferase/0.466
3qlrNDPDihydrofolate reductase1.5.1.30.466
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.466
1drhNAPDihydrofolate reductase1.5.1.30.465
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.465
1towCRZFatty acid-binding protein, adipocyte/0.465
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.465
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.465
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.464
1cf2NAPGlyceraldehyde-3-phosphate dehydrogenase/0.464
2iyfERYOleandomycin glycosyltransferase2.4.10.464
3ibqATPPyridoxal kinase/0.464
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3rdqDTBStreptavidin/0.464
4g2fC07Ephrin type-A receptor 32.7.10.10.464
4m9aFDAAcyl-CoA dehydrogenase/0.464
1lnmDTXBilin-binding protein/0.463
1u3dFADCryptochrome-1/0.463
2bfmTOPPteridine reductase 11.5.1.330.463
2c29NAPDihydroflavonol 4-reductase/0.463
2eglSAHDiphthine synthase/0.463
2pb6SAHDiphthine synthase/0.463
2y3sTIRTamL/0.463
3o0qADNVitamin B12-dependent ribonucleotide reductase/0.463
3zkdANPDNA gyrase subunit B/0.463
4dfrMTXDihydrofolate reductase1.5.1.30.463
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.463
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.463
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.463
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.462
1lkeDOGBilin-binding protein/0.462
2fhnBNIAvidin-related protein 4/5/0.462
2w6pOA4Biotin carboxylase6.3.4.140.462
2zgb21UProthrombin3.4.21.50.462
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3mauPLRPutative sphingosine-1-phosphate lyase/0.462
4a802ANMajor pollen allergen Bet v 1-A/0.462
4a99FADTetX family tetracycline inactivation enzyme/0.462
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.462
1n3rGTPGTP cyclohydrolase 13.5.4.160.461
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.461
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.461
1zgv501Prothrombin3.4.21.50.461
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.461
2e8hSAHDiphthine synthase/0.461
2nniMTKCytochrome P450 2C8/0.461
2p9dSAHDiphthine synthase/0.461
2rhrEMOPutative ketoacyl reductase1.3.10.461
2w6nOA2Biotin carboxylase6.3.4.140.461
2zf051UProthrombin3.4.21.50.461
3b2sB2STrichothecene 3-O-acetyltransferase/0.461
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3mvm39PMitogen-activated protein kinase 14/0.461
3t7x4SHEndothiapepsin3.4.23.220.461
4jlm1NNDeoxycytidine kinase2.7.1.740.461
4k9oTPPBenzoylformate decarboxylase4.1.1.70.461
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.461
4yvz3ATDNA integrity scanning protein DisA/0.461
1xddAAYIntegrin alpha-L/0.460
1z3cSA8mRNA cap guanine-N7 methyltransferase2.1.1.560.460
2bf7HBIPteridine reductase 11.5.1.330.460
2owuSAHDiphthine synthase/0.460
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3eq02TSProthrombin3.4.21.50.460
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.460
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.460
4bftZVTPantothenate kinase2.7.1.330.460
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
4jln18VDeoxycytidine kinase2.7.1.740.460
4kb81QOCasein kinase I isoform delta2.7.11.10.460
5dhgDGVNociceptin receptor/0.460
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.459
1dgmADNAdenosine kinase2.7.1.200.459
1jwtBLIProthrombin3.4.21.50.459
1me6IVSPlasmepsin-23.4.23.390.459
1ri3SAHmRNA cap guanine-N7 methyltransferase2.1.1.560.459
1yw8A75Methionine aminopeptidase 2/0.459
2e0nSAHPrecorrin-2 C20-methyltransferase/0.459
2ejzSAHDiphthine synthase/0.459
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.459
2wu4HBPAcetylcholinesterase3.1.1.70.459
2xlrFADPutative flavin-containing monooxygenase/0.459
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.459
2zvbSAHPrecorrin-3 C17-methyltransferase/0.459
3asjXYMHomoisocitrate dehydrogenase/0.459
3elePLPAminotransferase/0.459
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.459
4ek1CAMCamphor 5-monooxygenase1.14.15.10.459
4js1CTNBeta-galactoside alpha-2,6-sialyltransferase 12.4.99.10.459
4n3l2FNProthrombin3.4.21.50.459
4y35F90Endothiapepsin3.4.23.220.459
5a3bAPRSIR2 family protein/0.459
1mueCDDProthrombin3.4.21.50.458
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.458
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.458
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.458
2z6rSAHDiphthine synthase/0.458
2zgx29UProthrombin3.4.21.50.458
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.458
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.458
4fxy0W2Neurolysin, mitochondrial3.4.24.160.458
6stdMS2Scytalone dehydratase4.2.1.940.458
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.457
1kvkATPMevalonate kinase2.7.1.360.457
1v35NAIEnoyl-ACP reductase/0.457
2a9y26AAdenosine kinase2.7.1.200.457
2g1n1IGRenin3.4.23.150.457
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.457
2pswCOAN-alpha-acetyltransferase 50/0.457
2qe2452Polyprotein/0.457
2zsbADPPantothenate kinase2.7.1.330.457
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.457
3h3sH15Collagen type IV alpha-3-binding protein/0.457
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.457
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.457
4s1iPLPPyridoxal kinase, putative/0.457
1a8rGTPGTP cyclohydrolase 13.5.4.160.456
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
1trgCB3Thymidylate synthase/0.456
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.456
2op18PCEnoyl-ACP reductase/0.456
2znnS44Peroxisome proliferator-activated receptor alpha/0.456
3h2sNDPPutative NADH-flavin reductase/0.456
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.456
3p0hFSEPutative tyrosyl-tRNA synthetase/0.456
3p62FMNPentaerythritol tetranitrate reductase/0.456
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.456
4jxrACOAcetyltransferase/0.456
4m83ERYOleandomycin glycosyltransferase2.4.10.456
4q0kGA3Phytohormone-binding protein/0.456
4tjy3GNTankyrase-22.4.2.300.456
4zj8SUVOrexin receptor type 1/0.456
1dhrNADDihydropteridine reductase1.5.1.340.455
1n5dNDPCarbonyl reductase [NADPH] 1/0.455
1osvCHCBile acid receptor/0.455
1vbiNADMalate/L-lactate dehydrogenase family protein/0.455
2x06NADL-sulfolactate dehydrogenase/0.455
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3toxNAPPutative oxidoreductase/0.455
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
3w6hAZMCarbonic anhydrase 14.2.1.10.455
4bb3KKAIsopenicillin N synthase1.21.3.10.455
4dbzNDPPutative ketoacyl reductase1.3.10.455
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.455
4z24FADPutative GMC-type oxidoreductase R13510.455
5bsgNAPPyrroline-5-carboxylate reductase/0.455
1d4pBPPProthrombin3.4.21.50.454
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.454
1gveNAPAflatoxin B1 aldehyde reductase member 310.454
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.454
1qorNDPQuinone oxidoreductase 1/0.454
1u4oNDDL-lactate dehydrogenase1.1.1.270.454
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.454
1y9dTPPPyruvate oxidase1.2.3.30.454
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
2ok7FADFerredoxin--NADP reductase, apicoplast/0.454
3fr28CAFatty acid-binding protein, adipocyte/0.454
3junAKDPhenazine biosynthesis protein A/B/0.454
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.454
4bfxZVXPantothenate kinase2.7.1.330.454
4cmfPXGUncharacterized protein/0.454
4udqFAD5-(hydroxymethyl)furfural oxidase/0.454
4xg1LLPDiaminopimelate decarboxylase/0.454
1o2g696Prothrombin3.4.21.50.453
1ra3NAPDihydrofolate reductase1.5.1.30.453
1thnADPAnti-sigma F factor/0.453
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.453
2bu9HFVIsopenicillin N synthase1.21.3.10.453
2dv3SAHDiphthine synthase/0.453
2e8qSAHDiphthine synthase/0.453
2ibzUQ6Cytochrome b/0.453
2p5cSAHDiphthine synthase/0.453
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.453
2zfp19UProthrombin3.4.21.50.453
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.453
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.453
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.453
3h3t16HCollagen type IV alpha-3-binding protein/0.453
3o8gO8GHTH-type transcriptional regulator EthR/0.453
4umyNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.453
4xrgNADHomospermidine synthase2.5.1.440.453
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
5eccNAPDehydrofolate reductase type I/0.453
1dyjDDFDihydrofolate reductase1.5.1.30.452
1juvNDPDihydrofolate reductase1.5.1.30.452
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.452
1omoNADAlanine dehydrogenase/0.452
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.452
2bdyUNBProthrombin3.4.21.50.452
2briANPUridylate kinase2.7.4.220.452
2dxvSAHDiphthine synthase/0.452
2dxwSAHDiphthine synthase/0.452
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
2qboCAMCamphor 5-monooxygenase1.14.15.10.452
3f63GTXGlutathione transferase GST1-4/0.452
3gkaFMNN-ethylmaleimide reductase/0.452
3iqgASN_TRP_ASN_ILECysteine synthase2.5.1.470.452
3q43D66M1 family aminopeptidase3.4.110.452
3w8dNAD3-hydroxybutyrate dehydrogenase/0.452
4a862ANMajor pollen allergen Bet v 1-A/0.452
4b63NAPL-ornithine N(5)-monooxygenase/0.452
4f3gKAIGlutamate receptor 3/0.452
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.452
4jzr4JREgl nine homolog 1/0.452
4l4xNDPAmphI/0.452
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.452
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.452
1f0yCAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.451
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.451
2ek7SAHDiphthine synthase/0.451
2ekaSAHDiphthine synthase/0.451
2fonFADAcyl-coenzyme A oxidase/0.451
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.451
2gvdFKPAdenylate cyclase type 2/0.451
2gvdFKPAdenylate cyclase type 5/0.451
2huxSAHDiphthine synthase/0.451
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.451
2vkeTACTetracycline repressor protein class D/0.451
2vr1ATFBiotin carboxylase6.3.4.140.451
2wxvWXVCyclin-dependent kinase 22.7.11.220.451
2y3rTRKTamL/0.451
2zhf49UProthrombin3.4.21.50.451
3f1kNAPUncharacterized oxidoreductase YciK10.451
3fr4F8AFatty acid-binding protein, adipocyte/0.451
3h3r14HCollagen type IV alpha-3-binding protein/0.451
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3ipuO40Oxysterols receptor LXR-alpha/0.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4g95OAGDihydrofolate reductase1.5.1.30.451
4nh82LCHeat shock protein HSP 90-alpha/0.451
1h65GDPTranslocase of chloroplast 343.6.50.450
1hskFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.450
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.450
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.450
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.450
2e8rSAHDiphthine synthase/0.450
2ea2F77Methionine aminopeptidase 2/0.450
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.450
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.450
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.450
2xpuTDCTetracycline repressor protein class D/0.450
2ym1FADPhenylacetone monooxygenase1.14.13.920.450
3bk2U5PRibonuclease J/0.450
3bxoUPPdTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose/0.450
3h06VBPGlutamate receptor 2/0.450
3t3r9PLCytochrome P450 2A61.14.130.450
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.450
4ap1NAPSteroid monooxygenase/0.450
4cdmFO1Deoxyribodipyrimidine photolyase/0.450
4dpuAGSMevalonate diphosphate decarboxylase/0.450
4dx7DM2Multidrug efflux pump subunit AcrB/0.450
4l33F70Tankyrase-22.4.2.300.450
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.450
4stdBFSScytalone dehydratase4.2.1.940.450
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.450
5e8wSTUTGF-beta receptor type-12.7.11.300.450
1cjkFOKAdenylate cyclase type 2/0.449
1cjkFOKAdenylate cyclase type 5/0.449
1dirNADDihydropteridine reductase1.5.1.340.449
1qrpHH0Pepsin A-43.4.23.10.449
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.449
2bjfDXCCholoylglycine hydrolase3.5.1.240.449
2en5SAHDiphthine synthase/0.449
2ghlLIBMitogen-activated protein kinase 14/0.449
2p6iSAHDiphthine synthase/0.449
2pj4414Carboxypeptidase B/0.449
2zhe13UProthrombin3.4.21.50.449
3atrFDAConserved Archaeal protein/0.449
3biu10UProthrombin3.4.21.50.449
3c1y2BADNA integrity scanning protein DisA/0.449
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
3p19NDPPutative blue fluorescent protein/0.449
3pldF90Endothiapepsin3.4.23.220.449
3s55NADPutative short-chain dehydrogenase/reductase/0.449
3w2jQRODihydroorotate dehydrogenase (fumarate)1.3.98.10.449
4a83DXCMajor pollen allergen Bet v 1-A/0.449
4bfuZVUPantothenate kinase2.7.1.330.449
4jtrIZPAldo-keto reductase family 1 member C2/0.449
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
7stdCRPScytalone dehydratase4.2.1.940.449
1d3dBZTProthrombin3.4.21.50.448
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.448
1il0NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
1pqc444Oxysterols receptor LXR-beta/0.448
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.448
1tqf32PBeta-secretase 13.4.23.460.448
1uxjNADMalate dehydrogenase/0.448
1x1cSAHC-20 methyltransferase/0.448
2c20NADUDP-glucose 4-epimerase/0.448
2cftPLPPyridoxal phosphate phosphatase/0.448
2dsgSAHDiphthine synthase/0.448
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.448
2pciSAHDiphthine synthase/0.448
2zdv37UProthrombin3.4.21.50.448
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.448
3r83Z14Cyclin-dependent kinase 22.7.11.220.448
4a86H35Major pollen allergen Bet v 1-A/0.448
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.448
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.448
4l5b1UXDeoxycytidine kinase2.7.1.740.448
4nvk2NYPeroxidase/0.448
4rvnCOAPhenylacetate-coenzyme A ligase/0.448
1f06NDPMeso-diaminopimelate D-dehydrogenase1.4.1.160.447
1j9zFADNADPH--cytochrome P450 reductase/0.447
1tehNADAlcohol dehydrogenase class-31.1.1.10.447
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.447
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.447
2hr8SAHDiphthine synthase/0.447
2ibyCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.447
2v2vV124-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.447
2webPP4Penicillopepsin-13.4.23.200.447
2xw7NDPDihydrofolate reductase/0.447
3apwDP0Alpha-1-acid glycoprotein 2/0.447
3fpzAHZThiamine thiazole synthase/0.447
3iaeD7KBenzaldehyde lyase/0.447
3jpuTY4Transcriptional activator protein LasR/0.447
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.447
3orfNADDihydropteridine reductase1.5.1.340.447
3to3ATPPetrobactin biosynthesis protein AsbB/0.447
4b1rITCTetracycline repressor protein class D/0.447
4bfvZVVPantothenate kinase2.7.1.330.447
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.447
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.447
4psbGA3Cytokinin-specific binding protein/0.447
4s1hADPPyridoxal kinase, putative/0.447
4tx9AMZPhosphoribosyl isomerase A/0.447
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4x5hFOLDihydrofolate reductase1.5.1.30.447
4x5iFOLDihydrofolate reductase1.5.1.30.447
1ihiIU5Aldo-keto reductase family 1 member C2/0.446
1nbiSAMGlycine N-methyltransferase2.1.1.200.446
1o76CAMCamphor 5-monooxygenase1.14.15.10.446
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.446
2dhfDZFDihydrofolate reductase1.5.1.30.446
2ftoTMPThymidylate synthase/0.446
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.446
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.446
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.446
2vqbNAPPutative flavin-containing monooxygenase/0.446
2y6fM9FIsopenicillin N synthase1.21.3.10.446
3dmeFADPutative conserved exported protein/0.446
3rq8AP5ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.446
3upf0BUPolyprotein/0.446
4a8v2ANMajor pollen allergen Bet v 1-J/0.446
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.446
4i1iNADMalate dehydrogenase/0.446
4qysPLRTryptophan synthase beta chain 24.2.1.200.446
1mg5NAIAlcohol dehydrogenase1.1.1.10.445
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.445
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.445
1qoqIGPTryptophan synthase alpha chain/0.445
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.445
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2e7rSAHDiphthine synthase/0.445
2ejkSAHDiphthine synthase/0.445
2g9rG27Glycogen phosphorylase, muscle form2.4.1.10.445
2qbmCAMCamphor 5-monooxygenase1.14.15.10.445
2rc4ACOHistone acetyltransferase KAT6A/0.445
2y0mACOHistone acetyltransferase KAT8/0.445
3b9xNOSPyrimidine-specific ribonucleoside hydrolase RihB3.2.2.80.445
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.445
3qvpFADGlucose oxidase1.1.3.40.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4a81DXCMajor pollen allergen Bet v 1-A/0.445
4ap3FADSteroid monooxygenase/0.445
4b4vL34Bifunctional protein FolD/0.445
4de2DN3Beta-lactamase/0.445
4df2FMNNADPH dehydrogenase/0.445
4kbyC2EStimulator of interferon genes protein/0.445
4tuvCPZCytochrome P450 1191.140.445
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.445
1fmlRTLRetinol dehydratase/0.444
1jhaAAMNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.444
1pq944BOxysterols receptor LXR-beta/0.444
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.444
2e08SAHDiphthine synthase/0.444
2eh2SAHDiphthine synthase/0.444
2eniSAHDiphthine synthase/0.444
2ep7NADGlyceraldehyde-3-phosphate dehydrogenase/0.444
2huqSAHDiphthine synthase/0.444
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.444
2owvSAHDiphthine synthase/0.444
2zg050UProthrombin3.4.21.50.444
2zhq27UProthrombin3.4.21.50.444
2zhw12UProthrombin3.4.21.50.444
3a0tADPSensor histidine kinase/0.444
3af1GDPPantothenate kinase2.7.1.330.444
3bv2P38Mitogen-activated protein kinase 14/0.444
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.444
3o26NDPSalutaridine reductase/0.444
3tfyCOAN-alpha-acetyltransferase 502.3.10.444
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.444
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.444
4cfc7NVIntegrase/0.444
4du82P0Mevalonate diphosphate decarboxylase/0.444
4kgkGTPUncharacterized protein/0.444
4l0oPLPCystathionine gamma-synthase2.5.1.480.444
4q71FADBifunctional protein PutA/0.444
4r81FMNPredicted NADH dehydrogenase/0.444
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.444
1dz4CAMCamphor 5-monooxygenase1.14.15.10.443
1icqFMN12-oxophytodienoate reductase 11.3.1.420.443
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1lf3EH5Plasmepsin-23.4.23.390.443
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.443
1muuGDXGDP-mannose 6-dehydrogenase1.1.1.1320.443
1r2jFADFkbI/0.443
1ur5NADMalate dehydrogenase/0.443
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.443
2a94AP0L-lactate dehydrogenase1.1.1.270.443
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.443
2eh4SAHDiphthine synthase/0.443
2ew5Y12Peptide deformylase/0.443
2fznFADBifunctional protein PutA1.5.5.20.443
2huvSAHDiphthine synthase/0.443
2owgSAHDiphthine synthase/0.443
2pncCLUPrimary amine oxidase, liver isozyme/0.443
2xluNA7Putative flavin-containing monooxygenase/0.443
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.443
3d84NDPDihydrofolate reductase1.5.1.30.443
3dux64UProthrombin3.4.21.50.443
3nxxNDPDihydrofolate reductase1.5.1.30.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
4bfwZVWPantothenate kinase2.7.1.330.443
4dbc3QPAspartate aminotransferase2.6.1.10.443
4kp8E1GCarbonic anhydrase 124.2.1.10.443
4yntFDAGlucose oxidase, putative/0.443
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
4mqt2CUMuscarinic acetylcholine receptor M2/0.443
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.442
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.442
1kp2ATPArgininosuccinate synthase6.3.4.50.442
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.442
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.442
1tl7FOKAdenylate cyclase type 2/0.442
1tl7FOKAdenylate cyclase type 5/0.442
1wngSAHDiphthine synthase/0.442
1x1bSAHC-20 methyltransferase/0.442
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2e15SAHDiphthine synthase/0.442
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.442
2g1r3IGRenin3.4.23.150.442
2hdjNDPAldo-keto reductase family 1 member C2/0.442
2j2pSC2Ficolin-2/0.442
2pcmSAHDiphthine synthase/0.442
2qfvNAPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.442
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.442
2v59LZKBiotin carboxylase6.3.4.140.442
2xlpFADPutative flavin-containing monooxygenase/0.442
2y6o1N1Ephrin type-A receptor 42.7.10.10.442
3gwdFADCyclohexanone monooxygenase/0.442
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.442
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.442
3r4b74TGag-Pol polyprotein/0.442
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.442
4ef4C2EStimulator of interferon genes protein/0.442
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.442
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.442
4i6gFADCryptochrome-2/0.442
4yao2AMNADPH--cytochrome P450 reductase/0.442
1bcuPRLProthrombin3.4.21.50.441
1d3pBT3Prothrombin3.4.21.50.441
1fmjRTLRetinol dehydratase/0.441
1hfqMOTDihydrofolate reductase1.5.1.30.441
1j0d5PA1-aminocyclopropane-1-carboxylate deaminase3.5.99.70.441
1nooCAHCamphor 5-monooxygenase1.14.15.10.441
1obnASVIsopenicillin N synthase1.21.3.10.441
2dvlFADAcyl-CoA dehydrogenase/0.441
2eeqSAHDiphthine synthase/0.441
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.441
2g1s4IGRenin3.4.23.150.441
2hutSAHDiphthine synthase/0.441
2nyaMGDPeriplasmic nitrate reductase1.7.99.40.441
2p6lSAHDiphthine synthase/0.441
2uxuNARHTH-type transcriptional regulator TtgR/0.441
2xvhNAPPutative flavin-containing monooxygenase/0.441
3atyFMNProstaglandin F2a synthase/0.441
3c14FOKAdenylate cyclase type 2/0.441
3c14FOKAdenylate cyclase type 5/0.441
3c212BADNA integrity scanning protein DisA/0.441
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.441
3qt62P0Mevalonate diphosphate decarboxylase/0.441
3s1dZIRCytokinin dehydrogenase 11.5.99.120.441
3s8cCDPRibonucleoside-diphosphate reductase large chain 11.17.4.10.441
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.441
3wswNADL-lactate dehydrogenase/0.441
4aosFADSteroid monooxygenase/0.441
4b4w9L9Bifunctional protein FolD/0.441
4bamMM9Prothrombin3.4.21.50.441
4enhFVXCholesterol 24-hydroxylase/0.441
4f6w0SSCyclin-dependent kinase 82.7.11.220.441
4hjfC2EGGDEF family protein/0.441
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
5cyoGDPSeptin-9/0.441
5dp2NAPCurF/0.441
5hs1VORLanosterol 14-alpha demethylase/0.441
1a72PADAlcohol dehydrogenase E chain1.1.1.10.440
1gpnHUBAcetylcholinesterase3.1.1.70.440
1h62ANBPentaerythritol tetranitrate reductase/0.440
1ipeNDPTropinone reductase 21.1.1.2360.440
1j0xNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.440
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1re7FOLDihydrofolate reductase1.5.1.30.440
1v2hGUNPurine nucleoside phosphorylase2.4.2.10.440
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.440
2ejjSAHDiphthine synthase/0.440
2f3rG5PGuanylate kinase2.7.4.80.440
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.440
2h94FADLysine-specific histone demethylase 1A10.440
2hkoFADLysine-specific histone demethylase 1A10.440
2ohvNHLGlutamate racemase/0.440
2pckSAHDiphthine synthase/0.440
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.440
2trsPLSTryptophan synthase beta chain4.2.1.200.440
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.440
2zevIPEGeranylgeranyl pyrophosphate synthase/0.440
2zff53UProthrombin3.4.21.50.440
2zsiGA4Gibberellin receptor GID1A30.440
3ekuCY9Actin-5C/0.440
3ipkPMSSurface protein adhesin/0.440
3u2mFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.440
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.440
4du6GTPGTP cyclohydrolase 1/0.440
4emtC2EStimulator of interferon genes protein/0.440
4ly91YYGlucokinase regulatory protein/0.440
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.440