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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.251.000
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.552
1m2rMNYCasein kinase II subunit alpha2.7.11.10.529
4f081RSTyrosine-protein kinase JAK2/0.527
4c02TAKActivin receptor type-12.7.11.300.524
1eh4IC1Casein kinase I homolog 12.7.11.10.523
3be9P04Casein kinase II subunit alpha2.7.11.10.523
4dgmAGICasein kinase II subunit alpha2.7.11.10.523
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.522
2pvlP55Casein kinase II subunit alpha2.7.11.10.521
2pvhP19Casein kinase II subunit alpha2.7.11.10.520
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.518
4jajXU1Aurora kinase A2.7.11.10.516
1di8DTQCyclin-dependent kinase 22.7.11.220.515
1om1IQACasein kinase II subunit alpha2.7.11.10.515
1vjy460TGF-beta receptor type-12.7.11.300.515
1g5sI17Cyclin-dependent kinase 22.7.11.220.514
2pvnP63Casein kinase II subunit alpha2.7.11.10.514
4y93746Tyrosine-protein kinase/0.514
1m2qMNXCasein kinase II subunit alpha2.7.11.10.513
4e6d0NUTyrosine-protein kinase JAK2/0.511
1ke6LS2Cyclin-dependent kinase 22.7.11.220.509
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.508
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.507
1py5PY1TGF-beta receptor type-12.7.11.300.506
4aqc88ATyrosine-protein kinase JAK2/0.506
5dr6SKEAurora kinase A2.7.11.10.506
5dr9SKEAurora kinase A2.7.11.10.506
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.505
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.504
3iok1P6Tyrosine-protein kinase JAK2/0.504
4anmWULCasein kinase II subunit alpha2.7.11.10.504
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.504
1m2pHNACasein kinase II subunit alpha2.7.11.10.503
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.501
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.500
4dgnLU2Casein kinase II subunit alpha2.7.11.10.500
1h1s4SPCyclin-dependent kinase 22.7.11.220.498
4bgh3I6Cyclin-dependent kinase 22.7.11.220.498
4hge15VTyrosine-protein kinase JAK2/0.498
1ke7LS3Cyclin-dependent kinase 22.7.11.220.497
2zoq5IDMitogen-activated protein kinase 32.7.11.240.497
3le62BZCyclin-dependent kinase 22.7.11.220.497
3mtfA3FActivin receptor type-12.7.11.300.497
3rvg17PTyrosine-protein kinase JAK2/0.497
4fkv61KCyclin-dependent kinase 22.7.11.220.497
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.496
3hmm855TGF-beta receptor type-12.7.11.300.496
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.496
4hvh19RTyrosine-protein kinase JAK32.7.10.20.495
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.494
3eyhIZATyrosine-protein kinase JAK1/0.494
3w33W19Epidermal growth factor receptor2.7.10.10.494
1dz6CAMCamphor 5-monooxygenase1.14.15.10.493
2b7aIZATyrosine-protein kinase JAK2/0.493
2wouZZFTGF-beta receptor type-12.7.11.300.493
3sheI85MAP kinase-activated protein kinase 32.7.11.10.493
4fki09KCyclin-dependent kinase 22.7.11.220.491
1pxlCK4Cyclin-dependent kinase 22.7.11.220.490
3nynSGVG protein-coupled receptor kinase 62.7.11.160.490
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.490
4fkg4CKCyclin-dependent kinase 22.7.11.220.490
5itzLOCTubulin beta-2B chain/0.490
2h96893Mitogen-activated protein kinase 82.7.11.240.489
4ek816KCyclin-dependent kinase 22.7.11.220.489
4hvi19STyrosine-protein kinase JAK32.7.10.20.489
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.488
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.488
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.488
2x1nX1NCyclin-dependent kinase 22.7.11.220.487
5dpvSKEAurora kinase A2.7.11.10.487
1oirHDYCyclin-dependent kinase 22.7.11.220.486
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.486
3cgfJNFMitogen-activated protein kinase 102.7.11.240.486
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.486
4ivc1J6Tyrosine-protein kinase JAK1/0.486
3oafOAGDihydrofolate reductase1.5.1.30.485
4c61LMMTyrosine-protein kinase JAK2/0.485
5drdATPAurora kinase A2.7.11.10.485
4dgo0JWCasein kinase II subunit alpha2.7.11.10.484
4ele31IDihydrofolate reductase/0.484
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.483
2uzbC75Cyclin-dependent kinase 22.7.11.220.483
2w1hL0FCyclin-dependent kinase 22.7.11.220.483
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.483
4elg52JDihydrofolate reductase/0.483
1bw9NADPhenylalanine dehydrogenase/0.482
1ol5ADPAurora kinase A2.7.11.10.482
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.482
1xjdSTUProtein kinase C theta type2.7.11.130.482
2eufLQQCyclin-dependent kinase 62.7.11.220.482
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.482
2xa4AZ5Tyrosine-protein kinase JAK2/0.482
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.482
4k28NADShikimate dehydrogenase family protein/0.481
2a0cCK9Cyclin-dependent kinase 22.7.11.220.480
3efwAK8Aurora kinase A2.7.11.10.480
4iva1J5Tyrosine-protein kinase JAK2/0.480
2btrU73Cyclin-dependent kinase 22.7.11.220.479
3pxkPXKFocal adhesion kinase 12.7.10.20.479
3s2pPMUCyclin-dependent kinase 22.7.11.220.479
4bcoT6QCyclin-dependent kinase 22.7.11.220.479
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.479
4jboWPHAurora kinase A2.7.11.10.479
5dt0SKEAurora kinase A2.7.11.10.479
2b53D23Cyclin-dependent kinase 22.7.11.220.478
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.478
2np8CC3Aurora kinase A2.7.11.10.478
3lfqA28Cyclin-dependent kinase 22.7.11.220.478
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.478
4fkpLS5Cyclin-dependent kinase 22.7.11.220.478
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.478
4jia1K3Tyrosine-protein kinase JAK2/0.478
1diuBDMDihydrofolate reductase1.5.1.30.477
1me6IVSPlasmepsin-23.4.23.390.477
3ggfGVDSerine/threonine-protein kinase 26/0.477
3zmmF9JTyrosine-protein kinase JAK2/0.477
4f650S9Fibroblast growth factor receptor 1/0.477
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.477
1gii1PUCyclin-dependent kinase 22.7.11.220.476
2p2bPRXAcetyl-coenzyme A synthetase/0.476
2uzeC95Cyclin-dependent kinase 22.7.11.220.476
2w9hTOPDihydrofolate reductase1.5.1.30.475
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.475
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.475
2itpAEEEpidermal growth factor receptor2.7.10.10.474
2vv9IM9Cyclin-dependent kinase 22.7.11.220.474
3pxyJWSCyclin-dependent kinase 22.7.11.220.474
4fkj11KCyclin-dependent kinase 22.7.11.220.474
1oitHDTCyclin-dependent kinase 22.7.11.220.473
2y9qANPMitogen-activated protein kinase 12.7.11.240.473
3sw418KCyclin-dependent kinase 22.7.11.220.473
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4bgg844Activin receptor type-12.7.11.300.473
4dymIYZActivin receptor type-12.7.11.300.473
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.473
1aq1STUCyclin-dependent kinase 22.7.11.220.472
1y91CT9Cyclin-dependent kinase 22.7.11.220.472
2uzoC62Cyclin-dependent kinase 22.7.11.220.472
3gxlQIGTGF-beta receptor type-12.7.11.300.472
3r8lZ30Cyclin-dependent kinase 22.7.11.220.472
4ek610KCyclin-dependent kinase 22.7.11.220.472
4fkt48KCyclin-dependent kinase 22.7.11.220.472
4lfiGNPCasein kinase II subunit alpha2.7.11.10.472
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.472
5e8ySTUTGF-beta receptor type-22.7.11.300.472
2w1fL0FAurora kinase A2.7.11.10.471
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.471
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.471
3s7a684Dihydrofolate reductase1.5.1.30.471
4fv6E57Mitogen-activated protein kinase 12.7.11.240.471
4g95OAGDihydrofolate reductase1.5.1.30.471
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.470
2ci01CMLanosterol 14-alpha demethylase1.14.13.700.470
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.470
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.470
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.470
1unlRRCCyclin-dependent-like kinase 52.7.11.10.469
1w0xOLOCyclin-dependent kinase 22.7.11.220.469
2xmyCDKCyclin-dependent kinase 22.7.11.220.469
3lfnA27Cyclin-dependent kinase 22.7.11.220.469
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.469
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.469
4gub0Y4Casein kinase II subunit alpha2.7.11.10.469
1dayGNPCasein kinase II subunit alpha2.7.11.10.468
2a1nCAMCamphor 5-monooxygenase1.14.15.10.468
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.468
2qbmCAMCamphor 5-monooxygenase1.14.15.10.468
3adaNADSubunit alpha of sarocosine oxidase/0.468
4dxd9PCCell division protein FtsZ/0.468
4ehzJAKTyrosine-protein kinase JAK1/0.468
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.467
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.467
3lpbNVBTyrosine-protein kinase JAK2/0.467
3s1h56ZCyclin-dependent kinase 22.7.11.220.467
4a84DXCMajor pollen allergen Bet v 1-A/0.467
1dz8CAMCamphor 5-monooxygenase1.14.15.10.466
1udaUFGUDP-glucose 4-epimerase5.1.3.20.466
2wotZZGTGF-beta receptor type-12.7.11.300.466
3hllI45Mitogen-activated protein kinase 14/0.466
3r1yX76Cyclin-dependent kinase 22.7.11.220.466
3rni21ZCyclin-dependent kinase 22.7.11.220.466
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.466
4b4w9L9Bifunctional protein FolD/0.466
4hvg19QTyrosine-protein kinase JAK32.7.10.20.466
1dhrNADDihydropteridine reductase1.5.1.340.465
4eor4SPCyclin-dependent kinase 22.7.11.220.465
4fko20KCyclin-dependent kinase 22.7.11.220.465
4jbpYPHAurora kinase A2.7.11.10.465
4jqeANPCasein kinase II subunit alpha2.7.11.10.465
1nooCAHCamphor 5-monooxygenase1.14.15.10.464
2c6o4SPCyclin-dependent kinase 22.7.11.220.464
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.464
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.464
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.464
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.464
4ji91M3Tyrosine-protein kinase JAK2/0.464
1e9hINRCyclin-dependent kinase 22.7.11.220.463
1fm4DXCMajor pollen allergen Bet v 1-L/0.463
1ke5LS1Cyclin-dependent kinase 22.7.11.220.463
1urwI1PCyclin-dependent kinase 22.7.11.220.463
1xkkFMMEpidermal growth factor receptor2.7.10.10.463
3at3ATKCasein kinase II subunit alpha2.7.11.10.463
3bbrBHYGlutamate receptor 2/0.463
3d84NDPDihydrofolate reductase1.5.1.30.463
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
3vs3VSETyrosine-protein kinase HCK2.7.10.20.463
4ewhT77Activated CDC42 kinase 1/0.463
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.463
4r20AERCytochrome P450 family 17 polypeptide 2/0.463
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.462
2b52D42Cyclin-dependent kinase 22.7.11.220.462
2csnCKICasein kinase I homolog 12.7.11.10.462
2hckQUETyrosine-protein kinase HCK2.7.10.20.462
2rhgIGPTryptophan synthase alpha chain/0.462
3rak03ZCyclin-dependent kinase 22.7.11.220.462
4eok4SPCyclin-dependent kinase 22.7.11.220.462
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.461
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.461
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.461
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.461
4rrrA3TThreonine--tRNA ligase6.1.1.30.461
1ai9NDPDihydrofolate reductase1.5.1.30.460
1uyuCAMCamphor 5-monooxygenase1.14.15.10.460
2a1oCAMCamphor 5-monooxygenase1.14.15.10.460
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.460
2cig1DGDihydrofolate reductase1.5.1.30.460
2xngA0HAurora kinase A2.7.11.10.460
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
1ao8MTXDihydrofolate reductase1.5.1.30.459
1e1xNW1Cyclin-dependent kinase 22.7.11.220.459
2btsU32Cyclin-dependent kinase 22.7.11.220.459
2dv3SAHDiphthine synthase/0.459
2pvmP29Casein kinase II subunit alpha2.7.11.10.459
2qboCAMCamphor 5-monooxygenase1.14.15.10.459
2uznC96Cyclin-dependent kinase 22.7.11.220.459
3a1l2CCCytochrome P450/0.459
3cukFADD-amino-acid oxidase1.4.3.30.459
3eb0DRKUncharacterized protein/0.459
3k5uPFQAurora kinase A2.7.11.10.459
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.459
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.459
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.459
4l4dCAMCamphor 5-monooxygenase1.14.15.10.459
4y95746Tyrosine-protein kinase/0.459
1s3vTQDDihydrofolate reductase1.5.1.30.458
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2pvjP44Casein kinase II subunit alpha2.7.11.10.458
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.458
3h4vNAPPteridine reductase 11.5.1.330.458
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.458
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.458
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.458
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.458
4o0wADNAurora kinase A2.7.11.10.458
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.458
1kkq471Peroxisome proliferator-activated receptor alpha/0.457
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.457
2qblCAMCamphor 5-monooxygenase1.14.15.10.457
3eljGS7Mitogen-activated protein kinase 82.7.11.240.457
3mdvCL6Cholesterol 24-hydroxylase/0.457
4c9pCAMCytochrome P450/0.457
4ek1CAMCamphor 5-monooxygenase1.14.15.10.457
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.457
5dnrATPAurora kinase A2.7.11.10.457
1pd9CO4Dihydrofolate reductase1.5.1.30.456
1pxoCK7Cyclin-dependent kinase 22.7.11.220.456
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.456
2vttLZDCyclin-dependent kinase 22.7.11.220.456
2w17I19Cyclin-dependent kinase 22.7.11.220.456
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
2z97CAMCamphor 5-monooxygenase1.14.15.10.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.456
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.456
3rk507ZCyclin-dependent kinase 22.7.11.220.456
4egnTWOCytochrome P450/0.456
4eon1ROCyclin-dependent kinase 22.7.11.220.456
4ez30S0Cyclin-dependent kinase 22.7.11.220.456
4fks46KCyclin-dependent kinase 22.7.11.220.456
4l4aCAMCamphor 5-monooxygenase1.14.15.10.456
4tuvCPZCytochrome P450 1191.140.456
1bmfANPATP synthase subunit alpha, mitochondrial/0.455
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.455
1bwsNDPGDP-L-fucose synthase/0.455
1ke9LS5Cyclin-dependent kinase 22.7.11.220.455
1xddAAYIntegrin alpha-L/0.455
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.455
2znq401Peroxisome proliferator-activated receptor delta/0.455
3ddqRRCCyclin-dependent kinase 22.7.11.220.455
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3qqgX06Cyclin-dependent kinase 22.7.11.220.455
3qtuX44Cyclin-dependent kinase 22.7.11.220.455
3zh8C58Protein kinase C iota type2.7.11.130.455
4eji0QACytochrome P450 2A131.14.14.10.455
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.455
5e8wSTUTGF-beta receptor type-12.7.11.300.455
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.454
1phePIYCamphor 5-monooxygenase1.14.15.10.454
1ykr628Cyclin-dependent kinase 22.7.11.220.454
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.454
2m56CAMCamphor 5-monooxygenase1.14.15.10.454
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.454
3kvxFMYMitogen-activated protein kinase 102.7.11.240.454
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3rk708ZCyclin-dependent kinase 22.7.11.220.454
3v9y24LPeroxisome proliferator-activated receptor gamma/0.454
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.454
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.454
4ivd15TTyrosine-protein kinase JAK1/0.454
1dawANPCasein kinase II subunit alpha2.7.11.10.453
1t85CAMCamphor 5-monooxygenase1.14.15.10.453
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.453
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3fwjCAMCamphor 5-monooxygenase1.14.15.10.453
3koo24DBifunctional epoxide hydrolase 23.3.2.100.453
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
3unk0BYCyclin-dependent kinase 22.7.11.220.453
4h6rFDAProline dehydrogenase/0.453
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.453
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
4q73FADBifunctional protein PutA/0.453
1o76CAMCamphor 5-monooxygenase1.14.15.10.452
1pxmCK5Cyclin-dependent kinase 22.7.11.220.452
1xelUPGUDP-glucose 4-epimerase5.1.3.20.452
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.452
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.452
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.452
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.452
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.452
3fl8RARDihydrofolate reductase/0.452
3pe2E1BCasein kinase II subunit alpha2.7.11.10.452
3qqhX0ACyclin-dependent kinase 22.7.11.220.452
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.452
3vf9477Tyrosine-protein kinase SYK2.7.10.20.452
4b4vL34Bifunctional protein FolD/0.452
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
4fod0UVALK tyrosine kinase receptor2.7.10.10.452
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.452
4loqSB4Mitogen-activated protein kinase 14/0.452
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.451
1rx7FOLDihydrofolate reductase1.5.1.30.451
1u4dDBQActivated CDC42 kinase 1/0.451
1udbUFGUDP-glucose 4-epimerase5.1.3.20.451
2a1mCAMCamphor 5-monooxygenase1.14.15.10.451
2iw94SPCyclin-dependent kinase 22.7.11.220.451
3pqbVGPPutative oxidoreductase/0.451
3t3q9PLCytochrome P450 2A61.14.130.451
4deeADPAurora kinase A2.7.11.10.451
3a62STURibosomal protein S6 kinase beta-12.7.11.10.450
3cgoJNOMitogen-activated protein kinase 102.7.11.240.450
3cppCAMCamphor 5-monooxygenase1.14.15.10.450
3ddpRC8Cyclin-dependent kinase 22.7.11.220.450
3fwgCAMCamphor 5-monooxygenase1.14.15.10.450
3kfr3TLGag-Pol polyprotein/0.450
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.450
3qt62P0Mevalonate diphosphate decarboxylase/0.450
3r83Z14Cyclin-dependent kinase 22.7.11.220.450
3rk909ZCyclin-dependent kinase 22.7.11.220.450
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4a87NARMajor pollen allergen Bet v 1-A/0.450
4acm7YGCyclin-dependent kinase 22.7.11.220.450
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.450
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.450
5dt3ATPAurora kinase A2.7.11.10.450
5itzGTPTubulin alpha-1B chain/0.450
1dr2TAPDihydrofolate reductase1.5.1.30.449
1zz2B11Mitogen-activated protein kinase 14/0.449
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.449
2duv371Cyclin-dependent kinase 22.7.11.220.449
2hm9TRRDihydrofolate reductase1.5.1.30.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.449
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.449
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
2x7hPFNProstaglandin reductase 310.449
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.449
3nxxNDPDihydrofolate reductase1.5.1.30.449
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.449
4ei40Q2Tyrosine-protein kinase JAK1/0.449
1c2tGARPhosphoribosylglycinamide formyltransferase/0.448
1dr3TAPDihydrofolate reductase1.5.1.30.448
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.448
1q1rFADPutidaredoxin reductase1.18.1.50.448
1sh9RITGag-Pol polyprotein3.4.23.160.448
1t86CAMCamphor 5-monooxygenase1.14.15.10.448
2wedPP6Penicillopepsin-13.4.23.200.448
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3oqkS52Renin3.4.23.150.448
3pj8404Cyclin-dependent kinase 22.7.11.220.448
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.448
3wbbNAPMeso-diaminopimelate D-dehydrogenase/0.448
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.448
4c4jX21Dual specificity protein kinase TTK2.7.12.10.448
4q72FADBifunctional protein PutA/0.448
5e92ANPTGF-beta receptor type-22.7.11.300.448
5eccNAPDehydrofolate reductase type I/0.448
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.447
1dr3HBIDihydrofolate reductase1.5.1.30.447
1dr5NAPDihydrofolate reductase1.5.1.30.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.447
2p2jPRXAcetyl-coenzyme A synthetase/0.447
2r3iSCFCyclin-dependent kinase 22.7.11.220.447
2z3uCRRCytochrome P450/0.447
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3friSAH16S rRNA methylase/0.447
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.447
3own3OWRenin3.4.23.150.447
3qu0X40Cyclin-dependent kinase 22.7.11.220.447
3uyt0CKCasein kinase I isoform delta2.7.11.10.447
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.447
4erwSTUCyclin-dependent kinase 22.7.11.220.447
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.447
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4k4p3TLGag-Pol polyprotein/0.447
3emlZMAAdenosine receptor A2a/0.447
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.446
1oguST8Cyclin-dependent kinase 22.7.11.220.446
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.446
2r3lSCWCyclin-dependent kinase 22.7.11.220.446
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.446
3a9wNADNDP-sugar epimerase/0.446
3bhtMFRCyclin-dependent kinase 22.7.11.220.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.446
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4a81DXCMajor pollen allergen Bet v 1-A/0.446
4fklCK2Cyclin-dependent kinase 22.7.11.220.446
4l4cCAMCamphor 5-monooxygenase1.14.15.10.446
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.446
5eypLOCTubulin beta chain/0.446
1ia1NDPDihydrofolate reductase1.5.1.30.445
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.445
1lf2R37Plasmepsin-23.4.23.390.445
1lf3EH5Plasmepsin-23.4.23.390.445
1mq4ADPAurora kinase A2.7.11.10.445
1vyzN5BCyclin-dependent kinase 22.7.11.220.445
2a94AP0L-lactate dehydrogenase1.1.1.270.445
2c5nCK8Cyclin-dependent kinase 22.7.11.220.445
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.445
2xneASHAurora kinase A2.7.11.10.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
2zjmF1MBeta-secretase 13.4.23.460.445
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.445
3lxiCAMCytochrome P450/0.445
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.445
3pgqGY3Acetyl-CoA carboxylase/0.445
3r73X87Cyclin-dependent kinase 22.7.11.220.445
3s79ASDAromatase1.14.14.140.445
4cdmFO1Deoxyribodipyrimidine photolyase/0.445
4enhFVXCholesterol 24-hydroxylase/0.445
4g3rCAMCamphor 5-monooxygenase1.14.15.10.445
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4kkyCAMCamphor 5-monooxygenase1.14.15.10.445
5cnnANPEpidermal growth factor receptor2.7.10.10.445
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.444
1h0w207Cyclin-dependent kinase 22.7.11.220.444
1lp4ANPCasein kinase II subunit alpha2.7.11.10.444
2ca0PXICytochrome P450 monooxygenase PikC/0.444
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.444
2q5g1FAPeroxisome proliferator-activated receptor delta/0.444
2w06FRVCyclin-dependent kinase 22.7.11.220.444
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.444
2xru400Aurora kinase A2.7.11.10.444
3b70NAPEnoyl reductase LovC10.444
3ezvEZVCyclin-dependent kinase 22.7.11.220.444
3gobHXXDdmC/0.444
3rpy27ZCyclin-dependent kinase 22.7.11.220.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
3vob9PCCell division protein FtsZ/0.444
3vt7VDXVitamin D3 receptor/0.444
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
4aua4AUCyclin-dependent kinase 62.7.11.220.444
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.444
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.444
4ryvZEAProtein LlR18A/0.444
4xgxADPFAD:protein FMN transferase/0.444
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.443
1ia3TQ5Dihydrofolate reductase1.5.1.30.443
1phgMYTCamphor 5-monooxygenase1.14.15.10.443
2a4lRRCCyclin-dependent kinase 22.7.11.220.443
2cchATPCyclin-dependent kinase 22.7.11.220.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.443
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.443
3cgcFADCoenzyme A disulfide reductase/0.443
3qtxX43Cyclin-dependent kinase 22.7.11.220.443
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.443
4eh60ONMitogen-activated protein kinase 14/0.443
4fcr0TMHeat shock protein HSP 90-alpha/0.443
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.443
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.443
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.443
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.443
4n6hEJ4Delta-type opioid receptor/0.443
1dhjMTXDihydrofolate reductase1.5.1.30.442
1hviA77Protease/0.442
1rx8FOLDihydrofolate reductase1.5.1.30.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.442
2qk8MTXDihydrofolate reductase/0.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
2udpUPPUDP-glucose 4-epimerase5.1.3.20.442
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.442
2xb7GUIALK tyrosine kinase receptor2.7.10.10.442
2znpK55Peroxisome proliferator-activated receptor delta/0.442
3cobADPKinesin heavy chain-like protein/0.442
3qtrX36Cyclin-dependent kinase 22.7.11.220.442
3w551FMMitogen-activated protein kinase 12.7.11.240.442
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.442
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4fkq42KCyclin-dependent kinase 22.7.11.220.442
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.442
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
5fwnNAPPutative dehydrogenase/0.442
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.441
1pxjCK2Cyclin-dependent kinase 22.7.11.220.441
2ccu2D9Heat shock protein HSP 90-alpha/0.441
2fxeDR7Gag-Pol polyprotein3.4.23.160.441
2v7a627Tyrosine-protein kinase ABL12.7.10.20.441
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.441
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.441
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3oom507Activin receptor type-12.7.11.300.441
3pmy41LEndothiapepsin3.4.23.220.441
3r7vZ02Cyclin-dependent kinase 22.7.11.220.441
3wrhCAMCamphor 5-monooxygenase1.14.15.10.441
4a862ANMajor pollen allergen Bet v 1-A/0.441
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.441
4dtaADNAPH(2'')-Id/0.441
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4iwd1JCHepatocyte growth factor receptor2.7.10.10.441
4k771Q4Tyrosine-protein kinase JAK1/0.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4l4eCAMCamphor 5-monooxygenase1.14.15.10.441
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4qmzB49Serine/threonine-protein kinase 242.7.11.10.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.441
1dz4CAMCamphor 5-monooxygenase1.14.15.10.440
1f0xFADD-lactate dehydrogenase1.1.1.280.440
1hbvGANGag-Pol polyprotein/0.440
1idb0DOGag-Pol polyprotein/0.440
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1iwiCAMCamphor 5-monooxygenase1.14.15.10.440
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.440
1t88CAMCamphor 5-monooxygenase1.14.15.10.440
1yrdCAMCamphor 5-monooxygenase1.14.15.10.440
2d29FADAcyl-CoA dehydrogenase/0.440
2lfoGCHFatty acid-binding protein, liver/0.440
2xnbY8LCyclin-dependent kinase 22.7.11.220.440
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3l6jZ90Alr2278 protein/0.440
3orfNADDihydropteridine reductase1.5.1.340.440
3qtzX42Cyclin-dependent kinase 22.7.11.220.440
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.440
4cdmFADDeoxyribodipyrimidine photolyase/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.440
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4jq7KJQEpidermal growth factor receptor2.7.10.10.440
4q71FADBifunctional protein PutA/0.440
5hs1VORLanosterol 14-alpha demethylase/0.440