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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2etrY27Rho-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2etrY27Rho-associated protein kinase 12.7.11.11.000
2f2uM77Rho-associated protein kinase 22.7.11.10.548
3ncz3NCRho-associated protein kinase 12.7.11.10.532
4otiMI1Serine/threonine-protein kinase N1/0.532
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.495
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.481
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.481
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3nynSGVG protein-coupled receptor kinase 62.7.11.160.467
4bcmT7ZCyclin-dependent kinase 22.7.11.220.465
4l9i8PRRhodopsin kinase/0.462
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.461
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3a8wATPProtein kinase C iota type2.7.11.130.454
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
1fvv107Cyclin-dependent kinase 22.7.11.220.448
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3nux3NVCyclin-dependent kinase 62.7.11.220.441
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.440
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440